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Dr Jonathan Coulter

School of Pharmacy

Dr Jonathan Coulter

School of Pharmacy

Dr Coulter’s team focuses on understanding key mechanisms which contribute to cancer resistance, developing novel therapeutic strategies to overcome these. Typically, these are alterations within the tumour microenvironment e.g. hypoxia or altered tumour metabolism.

 

We employ emerging pharmaceutical engineering technologies to design novel nanoparticle solutions to solve the problem of poorly soluble drugs, controlled release platforms for the long-term delivery of radiosensitising nanoparticles, and active targeting strategies exploiting responses which underpin the response of a tumour to existing therapeutics.

 

The objective of the research is to identify novel sensitising adjuvants to existing cancer treatments, with protectable IP, that will ultimately deliver patient benefit.

Contact info

  • View Academic Profile
  • j.coulter@qub.ac.uk
  • +44 (0)28 9097 2253
  • @Dr_JA_Coulter

Research Interests

Open to PhD applications in the fields of:

  • Nanopharmaceuticals
  • Metalic/Gold nanoparticles
  • Tumour metabolism
  • Tumour microenvironment
  • Targeted delivery
  • Radiopharmaceuticals
  • Radiobiology
  • Targeted Immunotherapy

Make a PhD enquiry


Current Research Opportunities

  • Developing a controlled release biodegradable platform for nanomedicine delivery
  • A microfluidic approach to supressing tumour metabolism and enhancing treatment sensitivity

Public outreach & key achievements

  • Prostate Cancer UK funding: https://prostatecanceruk.org/research/research-we-fund/s14-004
  • MRC Confidence in Concept – Anti-inflammatory radiosensitising gold nanoparticles for the treatment of prostate cancer
  • EPSRC – Nanoengineered microneedle arrays for enhanced plasmonic photothermal therapy of basal cell carcinoma – EP/P034063/1
  • EPSRC - Improving patient outcome by integrating the generic with the personal – EPSRC EP/K039342/1
  • Research Funder NI overview: https://www.crowdfundinsider.com/tag/dr-jonathan-coulter/
  • Materials & Advanced TeChnologies for Healthcare - https://www.qub.ac.uk/schools/SchoolofPharmacy/MATCH/

Research students

PhD Title Elevating intracellular oxygen using tumour metabolism suppressing nanoparticles
Name Jie Feng 
Country China
Year of Study  2018-2021
   
PhD Title  PSMA targeted gold nanoparticles as effective prostate cancer radiosensitisers
Name Cancan Yin
Country China
Year of Study  2019-2022
   
PhD Title  Exploiting hyperactive glucose transporters: a targeting mechanism for drug loaded nanoparticles
Name Tongchuan Wang  
Country China
Year of Study 2019-2022
   
PhD Title Manipulating tumour metabolism to increase radiation sensitivity
Name Meabh Doherty
Country Northern Ireland
Year of Study 2020-2023

 


Alumni: Where are they now

PhD Title Development of a cell cycle computational model predicting outcome to novel nanotherapeutics.
Name Chris Emmerson 
Year of Study 2016-2020
Country  Northern Ireland
Current Position Celerion Clinical Trials. Drug interaction data analyst.
   
PhD Title Enhancing the radiosensitivity of prostate cancer using RALA Gold nano-complexes
Name Lindsey Bennie
Year of Study 2016-2019
Country  Scotland  
Current Position

Scientist at pHion Therapeutics working on a project using RALA, a direct consequence of her PhD studies. Lindsey will undertake her PhD viva in November 2019. 

   
PhD Title  Radiation induced inflammatory signalling in prostate cancer: A target for co-functionalised gold nanoparticles 
Name  Dr Natalie Owen 
Year of Study  2015-2018 
Country  England
Current Position Natalie relocated back to England and was successful in obtaining a Research Scientist position at the prestigious Sanger Institute, Cambridge, England.
   
PhD Title  Dr Shannon O’Neill
Name  Enhancing the radiocurability of prostate cancer using the anti-cancer stem cell agent, AD-01, and novel CD44-targeted gold nanoparticles
Year of Study  2015-2018
Country  Northern Ireland
Current Position Shannon is currently working Research scientist at Almac

 

 


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  • Faculty of Medicine, Health & Life Sciences

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  • Materials and Advanced Technologies for Healthcare

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97 Lisburn Road,
Belfast, BT9 7BL. 

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Phone :+44 (0)28 9097 2086
E-mail: pharmacyinfo@qub.ac.uk

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