Dr Margariti’s laboratory has invested on their unique expertise on cell reprogramming and induced pluripotent stem (iPS) cell technologies and they have developed patient- specific cells lines from diabetic donors in a petri dish based on fast and highly efficient approaches. To date, the group has generated more than 90 diabetic specific iPS cell lines from small volumes of patient blood.
These patient-specific cells are now valuable tools to study the underlying causes and mechanisms of the pathogenesis of endothelial cell dysfunction and develop new knowledge, biomarker of diabetes and vascular complications, and discover effective therapies.
The students will join a multi-disciplinary Centre and acquire training on cutting edge technologies in pluripotent stem cells, molecular biology, cell signaling, coding and non-coding RNAs in the context of diabetes and cardiovascular complications.
These skills will be an important foundation for whatever career path the student decides to follow in the future.
PUBLIC OUTREACH AND KEY ACHIEVEMENTS
PhD Title: Investigate the role of non-coding RNAs during Endothelial cells differentiation from Induced Pluripotent Stem Cells.
Name: Miss Magdalini Eleftheriadou
Years of Study: 2017-Present
Alumni: where are they now?
Dr Marta Vilà-González
PhD Title: Diabetic macular oedema: insight into the disease and iPSC for the stratifications of its treatment based on novel technologies
Years of Study: 2014-17
Current position: PDRA Cambridge University, UK