The aim of my research is to apply high throughput molecular genetic approaches, specifically next generation sequencing (NGS), to better understand disease processes such as diabetes in the eye and vascular system. One focus is upon small microRNAs and their role in regulating gene expression, communication between cells and their potential as circulating biomarkers.
We are also using single cell RNA sequencing to perform a ‘molecular dissection’ of the retina and study how the many cell types respond to diabetes.
The application of high throughput molecular biology techniques to study retinal, vascular and infectious diseases
MicroRNAs – their role in gene regulation and use as biomarkers
Transcriptomics – RNA-Seq, including single cell analysis
Microbial DNA sequencing
PUBLIC OUTREACH AND KEY ACHIEVEMENTS
Name: Wong, Ryan
Years of Study: 2
Name: Watson, Mark
Years of Study: 2
Name: Zang, Jinnan
Years of Study: 3
PhD Title: Characterisation of circulating extracellular microRNAs and development of a method for their absolute quantification
Years of Study: 2014-2016
Current position: Assay Development Scientist at Illumina (Previously Postdoctoral Research Scholar, Tufts University
PhD Title: Study of Nhlh2 transcription factor and its putative target genes in the retina
Years of Study: 2005-2008
Current position: Team Leader at Almac Diagnostics
PhD Title: The influence of microRNA's on gene expression and their impact on the retina
Years of Study: 2006-2009
Current position: Assistant Professor, P.G.I. Chandigarh
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