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Dr Brazil works in a molecular cell biology focused on the role of proteins such as Gremlin1, a secreted antagonist of BMP signaling, in kidney fibrosis and damage. He has been instrumental in the development of multiple unique in vitro and in vivo models to interrogate the biology of Grem1.

His recent data has extended to characterizing the role of Grem1 in colon cancer, and developing novel drug-discovery strategies to inhibit the action of Grem1 in human disease.

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My team offers an ideal environment for students interested in signal transduction and molecular cell biology, as well as mouse models of disease and drug discovery targeting Grem1 and other proteins involved in human disease.

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  • Organiser “Know Your Enemy: Disease-Focused Research at Queen’s” NI Science Festival outreach event (2016, 2017)
  • Presentation at Diabetes UK Public Awareness seminars and workshops
  • Nuffield Celebration Day Welcome lecture (2017)
  • Visits to schools and other locations to promote careers in science and medicine




Faculty of Medicine, Health and Life Sciences

School of Medicine, Dentistry and Biological Sciences

Wellcome-Wolfson Institute For Experimental Medicine

Centre for Experimental Medicine

Institute for Health Sciences

Research students

PhD Title: Elucidating the Role of Gremlin-1 in Colorectal Cancer

Name: Louise Dutton
Years of Study: Year 2
Country: England, UK

PhD Title: Lipoprotein related mechanisms involved in pre-eclampsia

Name: Rebecca McLeese
Years of Study: Year 3
Country: Northern Ireland, UK

Alumni: where are they now?

Dr. Deborah Lavin

PhD Title: Mechanisms and Models of Insulin Receptor Substrate-2 signalling in the kidney

Years of Study: 2013- 2017
Country: Ireland
Current position: Postdoctoral Fellow, Imperial College London, UK

Dr. Rachel Church

PhD Title: Elucidating the mechanisms of Gremlin1-mediated Bone Morphogenetic Protein antagonism and acute kidney injury in vivo

Years of Study: 2011-2015
Country: Northern Ireland, UK
Current position: Scientist, Almac Pharmaceuticals, Craigavon, Northern Ireland

Dr. Olivia O’ Leary

PhD Title: The Therapeutic Potential of Erythropoietin for ischaemic retinopathies

Years of Study: 2011-15
Country: Ireland
Current position: Postdoctoral Fellow, Roche Pharmaceuticals, Basel, Switzerland

Research at Queen's

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