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The Functional Genomics Group focusses on the use of cutting-edge genomics technologies to investigate transcription factor function and de-regulation in cancer with a particular interest in the p53 family.

We believe that a better understanding of the genome-wide targets, mechanism of action and consequences of de-regulation of key transcription factors; will allow us to identify cancer specific dependencies, that represent “Achilles heels”, exploitable with novel treatment strategies to improve patient outcomes.

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Dr McDade is interested in hearing from students and clinical trainees who wish to pursue PhD/MD/MPhil projects in:

  • Transcription dysfunction in disease

  • Functional genomics and integrative bioinformatics

  • Identification of novel genomically informed treatment strategies

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