The Functional Genomics Group focusses on the use of cutting-edge genomics technologies to investigate transcription factor function and de-regulation in cancer with a particular interest in the p53 family.
We believe that a better understanding of the genome-wide targets, mechanism of action and consequences of de-regulation of key transcription factors; will allow us to identify cancer specific dependencies, that represent “Achilles heels”, exploitable with novel treatment strategies to improve patient outcomes.
Dr McDade is interested in hearing from students and clinical trainees who wish to pursue PhD/MD/MPhil projects in:
Transcription dysfunction in disease
Functional genomics and integrative bioinformatics
Identification of novel genomically informed treatment strategies
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