Professor Paul Harkin
Professor Harkin’s research is focused on understanding the impact of mutations within the BRCA1 gene in the development and treatment of hereditary breast and ovarian cancer.
We are using a number of complementary strategies to investigate the role played by BRCA1 in both DNA damage repair and transcriptional regulation. We were the first lab to identify a novel BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability following DNA damage.
Professor Harkin is open to PhD applications in the general area of hereditary breast and ovarian cancer. DNA damage repair or transcriptional regulation.
His fields of interest include;
- DNA damage repair
- Transcriptional regulation
- Mechanisms of sensitivity/resistance to DNA damage based therapeutics
PUBLIC OUTREACH AND KEY ACHIEVEMENTS
Name: Dr. Colin McIlmunn (Clinical Fellow)
PhD title: The molecular and genetic characterisation of contralateral breast cancer
Years of Study: 2
Country: United Kingdom
Alumni: where are they now?
Name: Professor Richard Kennedy
PhD title: Functional analysis of BRCA1
Years of Study: 3
Current position: McClay Professor of Experimental Medicine, QUB and Vice President of biomarker discovery at Almac Diagnostics
Name: Dr Jekaterina Vohhodina
PhD title: Role played by BRCA1 in mRNA splicing
Years of Study: 3
Current position: Research Fellow in Genetics at Livingston Lab, Dana Farber Cancer Institute, Harvard Medical School
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