Elucidating the role of chromatin and epigenetic modifiers in Acute Myeloid Leukaemia.

D2_030_Research_2V

CCRCB

Funded PhD Opportunity

Elucidating the role of chromatin and epigenetic modifiers in Acute Myeloid Leukaemia.

Project Description

Progression and characteristics of Acute myeloid leukemia (AML) has been linked to several key pathways including inactivation of tumour suppressors and gain-of-function mutation of oncogenes. Studies of AML have increasingly shown that genetic alteration of epigenetic modulators often induces aberrations in chromatin modification/remodeling, gene expression program, and cellular states during leukaemogenesis.

This project aims to elucidate the molecular mechanisms underpinning the relationship between these modifiers and leukaemogenic pathways leading to impaired cell differentiation, self-renewal and proliferation. It is anticipated that chromatin modifying and epigenetic compounds will emerge as the next generation of anti-cancer therapies.

Supervisors 

Prof K Mills
Dr AT Kruythoff-Mohd Sarip

Entry Requirements

Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject.

English Language

Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.

The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
• A valid Certificate of Proficiency in English grade A or B;
• A valid Certificate of Advanced English grade A; or
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.

For a list of English Language qualifications also accepted by the School and University please see the following link:
http://www.qub.ac.uk/International/International-students/Applying/English-language-requirements/#English

The English Language Unit (ELU) offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained from the ELU http://www.qub.ac.uk/tefl/

Funding Notes

*FUNDING CONFIRMED – Leukaemia & Lymphoma NI*

Eligibility for both fees (£4260 for 2018/19, 2019/20 TBC) and maintenance (£14,777 for 2018/19, 2019/20 TBC) depends on the applicants being either an ordinary UK or EU resident.

Closing Date

Sunday, January 20, 2019

How to Apply

Please refer to 'Entry Requirements' for specific admissions criteria.

Apply online via the Queen's on-line application portal .  Guidance is available on the University’s Prospective Student pages.

When applying for a project, please choose ‘MEDICINE’ as your subject area/School.

Please ensure you adhere to the closing dates.

If you have any further queries please contact:  pgoffice.smdb@qub.ac.uk  or +44 (0) 28 9097 2619/2042.

Please visit the School of Medicine, Dentistry and Biomedical Sciences,  Centre for Cancer Research and Cell Biology, website for further details about the Centre.

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