Non-canonical G protein signalling of US28 as a new target for glioblastoma

male researcher working in a lab

CEM Funded Opportunity

Non-canonical G protein signalling of US28 as a new target for glioblastoma

Project Description

Glioblastoma (GBM) is a very aggressive type of brain cancer with an extremely poor prognosis. For most of GBM cases, infection by the human cytomegalovirus (HCMV) expressing the chemokine receptor US28 is responsible of this disease. This receptor displays a high oncomodulatory activity and signals through a broad panel of transcription factors and cytokines responsible for cell proliferation, survival, migration, angiogenesis and inflammation. An interesting feature of US28 is that as opposed to most receptors, US28 is mainly localised intracellularly and can signal very well in absence of ligand.

Consequently, the student in charge of this project will have the unique opportunity to have access to a wide variety of cutting-edge molecular tools to investigate the oncogenic contribution of the intracellular pool of US28 signalling receptors in GBM malignancy. The student will also benefit from a training in the new state-of-art Wellcome-Wolfson Institute for Experimental Medicine. This project is particularly exciting, important and very self-rewarding as it may lead to novel therapeutic avenues to fight against brain cancer and help millions of patients waiting for a real efficient treatment.



*FUNDING CONFIRMED – Department for the Economy (DfE)*

Eligibility for both fees (£4260 for 2018/19, 2019/20 TBC) and maintenance (£14,777 for 2018/19, 2019/20 TBC) depends on the applicants being either an ordinary UK resident or those EU residents who have lived permanently in the UK for the 3 years immediately preceding the start of the studentship.

Non UK residents who hold EU residency may also apply but if successful may receive fees only.

For further details re eligibility criteria (including academic, citizenship and residency criteria) please click on the following link: View Website

Entry Requirements 

Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject. 


Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score. 

The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is: 
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years; 
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17); 
• A valid Certificate of Proficiency in English grade A or B; 
• A valid Certificate of Advanced English grade A; or 
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking. 

For a list of English Language qualifications also accepted by the School and University please see the following link: 

The English Language Unit (ELU) offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained from the ELU



Dr B Plouffe

Dr E Evergren

Prof C Taggart

Closing Date

Closing date for application is: Sunday January 20, 2019

How to Apply

Please refer to 'Entry Requirements' for specific admissions criteria.

Apply online via the Queen's on-line application portal .  Guidance is available on the University’s Prospective Student pages.

When applying for a project, please choose ‘MEDICINE’ as your subject area/School.

Please ensure you adhere to the closing dates.

If you have any further queries please contact:  or +44 (0) 28 9097 2619/2042.


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