DISCOVER CUTTING EDGE CRITICAL CARE RESEARCH AT QUEEN'S
Queen's research focusses on improving outcomes for critically ill patients through innovative approaches, spanning multiple domains including sepsis management, respiratory failure, and critical care delivery systems.
By integrating clinical trials, translational research, and advanced biotechnological methods, researchers at Queen’s aim to develop evidence-based practices that enhance patient care. Collaborative efforts with global health organizations and interdisciplinary teams further strengthen impact, driving advancements that are rapidly translated into clinical practice to improve survival rates and quality of life for patients in critical care settings.
ARDS/ARF AND MECHANICAL VENTILATION STRATEGIES
- ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies
- Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial.
- Aspirin as a Treatment for ARDS: A Randomized, Placebo-Controlled Clinical Trial
- A new approach to weaning critically ill patients from mechanical ventilation across the UK
- Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS)
- Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients with Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial
- Evaluation of plasma biomarkers to understand the biology and heterogeneity of treatment effect in lower tidal volume ventilation facilitated by extracorporeal CO2 removal in acute hypoxemic respiratory failure: a secondary analysis of the REST trial
- Sedation and ventilator weaning bundle and time to extubation in infants with bronchiolitis: secondary analysis of the Sedation AND Weaning In Children (SANDWICH) trial
- Ongoing Clinical Trial: The MARCH trial - Researching the clinical and cost effectiveness of mucoactive drugs in acute respiratory failure
- Ongoing Clinical Trial: SINFONIA clinical trial comparing two drugs used to improve recovery from general anaesthesia and prevent lung complications in patients undergoing major surgery
COVID-19
- Interleukin-6 receptor antagonists in critically ill patients with Covid-19
- Simvastatin in Critically Ill Patients with Covid-19
- Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial
- Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicenter, Randomized, Controlled Clinical Trial.
- Long-term (180-day) outcomes in critically ill patients with COVID-19 in the REMAP-CAP randomized clinical trial
- Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study
- Accelerated immune ageing is associated with COVID-19 disease severity
FLUIDS AND SEPSIS
- Fluid management and active fluid removal practices: a global survey of paediatric critical care physicians
- Vascular leak in sepsis: physiological basis and potential therapeutic advances
- Fluid Therapy in Sepsis - Does it Matter How Much?
- Early switch to oral antibiotic therapy in patients with low-risk neutropenic sepsis (EASI-SWITCH): a randomized non-inferiority trial
- Vascular leak in sepsis: physiological basis and potential therapeutic advances
- Sepsis subphenotypes, theragnostics and personalized sepsis care
- The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study
- Ongoing Clinical Trial: SepTIC Trial – aiming to answer three important questions, Is it better for patients if we use rapid microbiology tests (that take only a few hours to work out what the infection is) to allow antibiotics to be changed early? Is it better for patients with sepsis to have less fluid than current standard care? Does it help to give the sickest patients with sepsis and low white blood cell counts (a sign of a weakened immune system) a drug that stimulates the immune system?
REHABILITATION AFTER ICU
- Opioid, sedative, pre-admission medication and iatrogenic withdrawal risk in UK adult critically ill patients: a point prevalence study
- Recovery following discharge from intensive care: what do patients think is helpful and what services are missing?
- Do critical illness survivors with multimorbidity need a different model of care?
- Factors to consider when designing post-hospital interventions to support critical illness recovery: systematic review and qualitative evidence synthesis
- Magnetic resonance imaging in comatose adults resuscitated after out-of-hospital cardiac arrest: a posthoc study of the targeted therapeutic mild hypercapnia after resuscitated cardiac arrest trial
- Thirst in adult patients in the intensive care unit: A scoping review - Queen's University Belfast
- National screening for delirium in paediatric intensive care units: a quality improvement initiative
- Ongoing Clinical Trial: iRehab – Researching the clinical and cost effectiveness of a remote multicomponent rehabilitation intervention compared to
standard care in survivors of critical illness following discharge home.
