Research Profile: Rhianne Curley
I joined the CDT in September 2020. Prior to that I completed my BSc in Biotechnology at Dublin City University. While studying for my Bachelors degree I had the opportunity to complete a 9 month integrated training placement in Bristol-Myers Squibb, Cruiserath, as a member of the manufacturing science and technology upstream team. This opportunity allowed me to experience first-hand the benefits of industry placements for both enhancing lab based skills and also for personal development. The option to gain industry experience while completing my PhD made the PIADS programme an extremely unique and attractive opportunity to me.
PhD Project: Precision targeted tumor responsive fluorophores: theranostic probes for real time biomarker sensing and for intraoperative fluorescence guided surgery
Supervisor: Professor Tia Keyes, Dublin City University
The long-term aim of this project is to develop and optimise luminescent probes that can be used to selectively target cancer cells. These probes will have an application in both light-guided surgery and also in photonics.
My main area of focus at the moment is the photophysical characterisation of Ruthenium probes and the use of these probes for imaging and measuring oxygen in cells using microscopy techniques such as Fluorescence-lifetime imaging microscopy, confocal miscroscopy and super-resolution stimulated emission depletion (STED) microscopy.
In selecting this PhD project I was motivated by a desire to strengthen my knowledge and enhance my skills in biophotonics and imaging. I have a keen interest also in immune-oncology with which this project is closely aligned.
Aside from this, I enjoy traveling, yoga and hiking.