The trial involved 889 people with colon cancer from six different countries, including the UK. Researchers monitored the impact of a structured physical activity programme for people recovering from treatment, compared to those who were offered just health education materials. 

The exercise programme lasted for three years and involved patients regularly meeting with a physical activity consultant. For the first six months, patients received in-person coaching sessions every week. Over time, this was reduced to one session per month, either in-person or online. Exercise was tailored to each individual and varied from a brisk walk to circuit classes.

The study showed that: 

• After five years, 80% of people in the structured exercise group remained cancer-free, compared with 74% in the health education materials group. This means the risk of dying, cancer coming back, or developing a new cancer, was over a quarter (28%) lower in the exercise group. 

• After eight years, overall survival was 90% in the structured exercise programme and 83% in the health education materials group. Patients had over a third (37%) lower risk of death if they participated in the structured exercise programme. 

Every year, around 31,800 people are diagnosed with colon cancer in the UK. Thanks to the power of research, trials like this can inform clinical practice and help to improve people’s chances of survival. 

"It's a bit of a mind-shift, thinking of treatment as something you do, not just something you take," said Professor Vicky Coyle, UK lead researcher for the trial and Clinical Professor at the Patrick G. Johnston Centre for Cancer Research (PGJCCR) in an interview with BBC.

“During the trial, we supported people to reach their weekly exercise target in a way that worked for them," said Professor Coyle. This could be a brisk walk for around 40 minutes every day, but some patients were also doing circuit classes, cycling, swimming, and many other activities.

“Our study gives clear, encouraging evidence that physical activity can reduce the risk of cancer returning for some people with colon cancer. We now need to work with policymakers and healthcare providers to embed exercise into treatment plans where appropriate.” 

Caroline Geraghty, Senior Specialist Information Nurse at Cancer Research UK, said: "Being active has many benefits, and this study shows that exercise doesn’t only improve wellbeing – it can also boost people’s chances of surviving colon cancer. 

“Everyone recovering from cancer should have access to tailored support to help them live longer, better lives. This trial has the potential to transform clinical practice, but only if health services have the necessary funding and staff to make it a reality for patients. 

"It’s important to remember that every cancer journey is different – starting new activities after treatment can feel overwhelming, and it may not be the right option for everyone. Take things at your own pace and speak to your doctor to discuss what is safe for you.” 

Dr Joe Henson, Associate Professor in Lifestyle Medicine at the University of Leicester: “These exciting results highlight the power of exercise to reduce the risk of cancer returning and improve people’s quality of life. Leading the exercise sessions in Leicester, I saw first-hand that this reduced fatigue, lifted people’s mood, and boosted their physical strength. We know that physical activity regulates several key biological processes that could explain these results, and further research will help us uncover why exercise is having such a positive impact.  

“Despite its proven benefits, many people still face barriers to engaging in regular exercise. This study shows how important it is to make exercise advice a routine part of cancer care and to offer people tailored support.” 

Margaret Tubridy, 69 years old and from North Belfast, took part in the CHALLENGE-UK clinical trial. She said: "I wanted to take part in the trial to help other people living with cancer. I had never exercised in my life, but with the right support and encouragement I was able to walk more and more. From there I started going to classes at the gym and now I do weight training twice a week, pole walking, and I’m in a walking group. I had never been to a gym before, but once I was shown how to use the machines and do the exercises, I loved it.  

"It’s been almost five years since my cancer diagnosis and if I meet anyone, I tell them I am doing great. Taking part in the trial helped me so much – I am stronger, fitter, and my anxiety is better. I never thought at 69 years of age I would be able to do all of this – I am chuffed to bits.”