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School Research Seminar - Professor Peter Crowley - NUI Galway

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"Macrocycle-mediated Protein Frameworks"

An image of Professor Peter Crowley
Date(s)
October 21, 2020
Location
School of Chemistry and Chemical Engineering - ONLINE seminar
Time
14:00 - 15:00

Precisely defined protein aggregates as exemplified by crystals have applications in functional materials. Consequently, engineered protein assembly is a rapidly growing field.

Anionic calix[n]arenes are useful scaffolds that can mould to cationic protein surfaces and induce oligomerisation / assembly. Here, we describe the fabrication of different types of protein frameworks via co-crystallization with sulfonato-calix[8]arene. Calixarene-masked proteins act as nodes within the frameworks, displaying octahedral-type coordination in one case. Such supramolecular protein chemistry may benefit the development of biomaterials and therapeutics.

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