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GENIE EWAS in Nature Communications

Type 1 diabetes can neither be cured nor prevented and affects >9 million individuals globally. We provide new knowledge on the underlying genetic and environmental background to diabetic kidney disease and offer new targets for preventative care.

Genetics of Nephropathy: An International Effort

For people living with type 1 diabetes, lifelong levels of high blood glucose levels in these individuals can result in several disabling and life-threatening complications, with kidney disease being the most devastating.  Diabetic kidney disease affects up to one-third of individuals with type 1 diabetes, often leading to kidney failure and premature death. Therefore, preventing diabetic kidney disease and slowing its progression is of the utmost importance.

This study is the largest genome-wide evaluation of blood-derived DNA methylation on diabetic kidney disease in type 1 diabetes. We identified 32 CpGs sites, in 28 distinct loci, with altered methylation in DKD (p≤9.9×10-8). Methylation at 22 CpG sites was associated with the gene expression of the underlying gene; and of the underlying genes, 19 were differentially expressed in kidneys in diabetic kidney disease or correlated with pathological kidney traits.

Identifying epigenetic signatures associated with diabetic kidney disease can help us understand both the underlying genetic and environmental background behind the disease and offer new targets for preventative care. This study identified both known and several new sites associated with diabetic kidney disease in type 1 diabetes. 

Summary statistics for each of the meta-analysis models are available to download as .zip files, which when extracted are .txt files.

minimal model.zip

maximal model.zip

Min smoking model.zip

README file

If you use this data in any research, please cite: xxxx

 

 

 

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