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In This Section
  • Find a PhD Supervisor
  • PhD Opportunities

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Find a PhD Supervisor

Dr Joseph S. Vyle

School of Chemistry and Chemical Engineering
Joseph Vyle

Dr Joseph S. Vyle

School of Chemistry and Chemical Engineering

In collaboration with the School of Pharmacy (Professor Helen McCarthy), we are developing methods which will allow the delivery of phosphorylated drugs and prodrugs to cancer via nanoparticles. Our specific interest is in the modification of nucleic acids with selenium which increases the nuclease stability of DNA and RNA but can enable drug release upon encountering the pathophysiological conditions encountered in the tumour microenvironment. Selenium also provides valuable structural information about biologically-active conformations both in solution and crystalline material.

Contact info

  • View Academic Profile
  • j.vyle@qub.ac.uk
  • +44 28 9097 5485
  • @vylelab

Research Interests

Open to PhD applications in:

  • DNA analogue synthesis, delivery and solid state NMR

Make a PhD enquiry


Public outreach & key achievements

  • Demonstration lectures to A-level chemistry students


Research students

Lawrence Hale, Synthesis and evaluation of biologically-active nucleic acids delivered by RALA, 2021-2024, UK


Alumni: Where are they now

Olga Eguaogie, Nucleoside and nucleotide analogues containing chalcogens, 2014-2017, Germany, Almac

Patrick F. Conlon, Novel Approaches to the synthesis of selenium modified nucleosides, nucleotides and nucleic acids, 2016-2019, Almac, N. Ireland, Almac

Jordan J. Wilson, Forging novel anticancer agents and cellular espionage using RALA, 2018-2021, UK, pHionX


Discover More

  • Faculty of Engineering And Physical Sciences
  • School of Chemistry and Chemical Engineering
  • School of Pharmacy

Postgraduate research
Apply now
Your postgraduate experience
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