Immunobiology and Microbes Case Study: Professor Ultan Power and Professor Mike Shields

"Our struggle against infectious diseases is far from over. Shockingly, the increasing isolation of microbes resistant to "last resort" antimicrobials has already narrowed, and in some settings completely removed, the treatment options against infections.

Rising to this global health challenge, we are harnessing basic knowledge about how microbes weakens our defences to develop new therapeutics based on enhancing our defences, and ameliorating pathophysiological tissue destruction."

Respiratory Medicine Case Study: Professor Danny McAuley and Professor Cecila O'Kane

"When people are critically ill their lungs can fail. This is termed the Acute Respiratory Distress Syndrome (ARDS) and means that the lungs fill with water instead of air. Breathing becomes difficult and a ventilator in intensive care is needed to take over their breathing. ARDS is a common and devastating condition affecting critically ill patients. Currently, there is no effective treatment for ARDS. The aim of our research is to find potential new treatment for this devastating lung disease that could help save many lives each year. To achieve this we have established a translational programme to test new therapies in clinically relevant models of ARDS, in early phase experimental medicine trials and finally in large definitive trials with the potential to have major impact on clinical care of these patients."