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Centre for Cancer research and Cell Biology

Research Opportunities

Supervisors

  • Integrate molecular and epidemiological data from populations
  • Breast and Prostate cancer
Dr Emma Allott
  • Gynaecological Cancer
  • Surgical Gynaecological research
Dr James Beirne
  • Technology/platform-agnostic prior knowledge transfer 
  • Compositional statistics
  • Pre-clinical model selection/characterisation
  • Prognostic/predictive subtyping
  • Consensus/meta-clustering
  • Landmark analysis
  • Progression routes from pre-malignancy to cancer
  • Mixed signal deconvolution/convolution
Dr Jaine Blayney
  • Metastatic progression
  • Pre-metastatic organ microenvironment
  • Pathophysiology of cancer
  • Microvascular function and tissue regeneration
  • Remodelling resulting from both disease and treatments
Dr Cristina Branco
  • Mechanisms of radioresistance
  • Drug radiotherapy combinations
  • In vivo models and small animal radiotherapy
  • Nanoparticle theranostics
Dr Karl Butterworth
  • Radiobiology of targeted radionuclides (Radium-223)
  • Clinical trials
  • Stereotactic Radiotherapy
  • Radiation Biology
  • Prostate Cancer
Dr Aidan Cole
  • Cancer clinical trials
  • Basic scientific and translational investigation of mechanisms of treatment resistance
Dr Vicky Coyle
  • Investigate molecular mechanisms involved in dysregulation of the ubiquitin proteasome system in multiple myeloma
  • Identify opportunities for therapeutic intervention
Dr Lisa Crawford
  • Receptor signalling
  • Membrane trafficking
  • Inter-organelle interactions
Dr Emma Evergren
  • Developing clinical biomarker strategies in cancer
  • Using comprehensive genomic approaches to detect DNA alterations
Professor David Gonzalez de Castro
  • DNA damage repair
  • Transcriptional regulation
  • Mechanisms of sensitivity/resistance to DNA damage based therapeutics
Professor Paul Harkin
  • Identifying novel predictive and prognostic biomarkers for radiotherapy treatment in prostate cancer
Dr Suneil Jain
  • Digital molecular pathology approaches to characterize the immune contexture of cancers using high quality bio samples
  • Investigating the role of the oral microbiome in cancer risk and malignant transformation
  • Identifying and validating molecular biomarkers for stratification of patients with cancers
Dr Jacqueline James
  • Characterisation of a molecular group in solid cancers that represents an innate immune response to DNA damage through the STING pathway
  • Development of a gene expression based biomarker panel that can identify pathways related to the hallmarks of cancer and guide patient therapy
Professor Richard Kennedy
  • Investigate key processes involved in the underlying biology driving epigenetic alterations
  • Nucleotide metabolism in cancer development
  • Novel drug targeting of these processes through in vitro cell line-based models and in vivo cancer mouse models
Dr Melissa LaBonte Wilson
  • Cancer biology
  • Cell death
  • Drug resistance
Professor Daniel Longley
  • Integrative analytics & software design
  • Insights into patient heterogeneity
  • AI and Machine Learning
Dr Daragh McArt
  • Characterisation of a molecular group in solid cancers that represents an innate immune response to DNA damage through the STING pathway
  • Development of a gene expression based biomarker panel that can identify pathways related to the hallmarks of cancer and guide patient therapy
Dr Nuala McCabe
  • Benign or malignant urology
  • Ion channels in health and disease
Dr Karen McCloskey
  • Transcription dysfunction in disease
  • Functional genomics and integrative bioinformatics
  • Identification of novel genomically informed treatment strategies
Dr Simon McDade
  • Improved understanding of tumour initiating events in BRCA mutation carriers
  • Investigation and management of breast cancer risk
  • Development of treatment biomarkers in the pre-surgical setting
Dr Stuart McIntosh
  • Modelling responses to radiotherapy, including
  • Proton Relative Biological Effectiveness
  • Intrinsic radio sensitivity
  • The impacts of intercellular communication on radiation responses
Dr Stephen McMahon
  Professor Ian Mills
  • Investigations into molecular mechanisms in myeloid blood cancers including epigenetic alterations
  • DNA repair deficiency
  • Altered signal pathways to identify therapeutic targets for novel agents or repurposed drugs using drug screens and/or NGS technologies to improve patient outcomes
Professor Ken Mills
  • Transcriptional control
  • Signal transduction
  • Chromatin remodelling and epigenetics
  • DNA damage signalling
  • Cell Senescence
  • Molecular cell biology
  • Biochemistry
Dr Paul Mullan
  • Cancer predisposition genetics
  • Molecular pathology
  • Functional genetics
Dr Nick Orr
  • Bone-seeking radionuclides in prostate cancer
  • New therapeutics in CRPC
  • Advanced radiotherapy in prostate cancer
  • Genomic stratification in prostate cancer
Professor Joe O'Sullivan
  • Systems Medicine, Network Biology, Precision Medicine; with applications to cancer biomedicine.
  • Funded PhD studentship 2019-2022, project title: Precision Diagnostics For Novel Cancer Patient Journey-wide Phenotypes
Dr Ian Overton
  • STING pathway across cancers
Dr Eileen Parkes
  • Optimization of bone-seeking radionuclides for targeted molecular radiotherapy
  • Defining stem-cell mediated radio resistance in recurrent brain tumours
  • Building a biological-based rationale for the use of particle-based radiotherapies
  • Understanding Radiation-induced bystander and abscopal responses
  • Defining Next generation laser-produced ion-beams for advanced radiotherapy
Professor Kevin Prise
  • Cellular DNA damage response system and its link with cancer development
Dr Kienan Savage

 

Professor Manuel Salto-Tellez
  • Nano medicine
  • Antibody therapeutics
  • Proteases and pancreatic cancer
Professor Christopher Scott
  • Chromatin remodelers
  • Epigenetics
  • Cancer metastasis
  • Proteomics
  • Molecular cell biology
  • Biochemistry
Dr Adone Tielenius Kruythoff-Mohd Sarip
  • Laboratory based investigation of novel drugs and biomarkers
  • Discovery of resistance mechanisms to therapy
  • Innovative biomarker development using clinical samples
Dr Richard Turkington
  • Laboratory based investigations into molecular mechanisms including altered pro-survival signalling pathways in RASMT and BRAFMT CRC
  • Discovery of novel resistance mechanisms to therapy mechanisms in RASMT and BRAFMT CRC
  • Innovative biomarker development using samples from RASMT and BRAFMT CRC patients
Dr Sandra Van Schaeybroeck
  • Development of Novel Cathepsin V inhibitors to Validate role in Breast Cancer
  • Testing of Epigenetic Probes in Cancer Immune Cells
  • Design, synthesis and SAR exploration of Novel LSD1 inhibitors
Dr Richard Williams

Centre for Public Health

 

Research Opportunities

Supervisors

  • Cancer epidemiology
  • Autoimmune conditions in particular pernicious anaemia
Dr Lesley Anderson
  • Primary and secondary research on visual disorders
Professor Augusto Azuara-Blanco
  • Novel methodological approaches for cancer survival analysis
Dr Finian Bannon
  • Use of systems approaches
  • Analytics/intelligence and modelling to improve the quality and safety of health and social care
Dr Declan Bradley
  • Epidemiology
  • Pharmacoepidemiology
Dr Christopher Cardwell
  • Improving the quality and usefulness of trials and reviews
  • Conducting health services research more generally
  • Conducting research relevant to humanitarian emergencies
Professor Mike Clarke
  • Data analysis
  • Epidemiology projects related to oesophageal or colorectal cancer and pre-malignant conditions
Dr Helen Coleman
  • Strategies to correct and prevent myopia among children in low-resources areas of LMICs
  • Measuring early outcomes in cataract surgery in underserved areas
  • Improved care for complex diseases such as glaucoma and diabetic eye disease in rural Asia
Professor Nathan Congdon
  • Mental Health
  • Ageing
  • Co-morbidity/Multi-morbidity
  • Social determinants of health/social environment
  • Subjective well-being
Dr Sharon Cruise
  • Development and evaluation of health services and public health interventions
  • Implementation science and improvement science
  • Integrated health and social services
  • Service organization and delivery
Professor Michael Donnelly
  • Stem cells and regenerative therapies
  • Orofacial pain
  • Minimal intervention dentistry
  • Oral infections and systemic health
Dr Ikhlas El Karim
  • Patient reported outcomes data on 35,000 prostate cancer patients from the UK
  • Excellent data of all cancer patients diagnosed since 1993
  • Databases on premalignant disease and PSA database
  • Stroke registry to be established
  • Possible cardiovascular in future
Dr Anna Gavin
  • Ophthalmic epidemiology
  • Optometry
  • Vision science
  • Psychophysics
  • Ophthalmology
Dr Ruth Hogg
  • The role of social networks and network interventions for behaviour change
  • Developing and investigating the public health impact of population level built and social environment interventions
Dr Ruth Hunter
  • Opportunities in life-course epidemiology and methods, complex public health interventions and decision sciences

Professor Frank Kee

  • Cancer Epidemiology
  • Pancreatic cancer
  • Early detection of cancer

Dr Andrew Kunzmann

  • Blindness prevention
  • Paediatric palliative care
Dr Lynne Lofield
  • Social science or clinical background
Dr Aideen Maguire
  • Large scale genomics of chronic kidney disease including genome-wide and epigenetic association studies
  • Clinical epidemiology of chronic kidney disease
  • Decision making and conservative management of end-stage renal disease
  • Medical education projects with focus on intravenous fluid therapy
Professor Peter Maxwell
  • Epidemiology
  • Rare disease, research methodology, health service research and network analysis. 
Dr Helen McAneney
  • Development and implementation of psychological interventions for people with neurodegenerative illness
  • Implementation of quality improvement programs in palliative care
  • Development and implementation of healthcare quality inspection techniques
  • Development and implementation of evidence-based interventions for reduction of loneliness among older people
Dr Noleen McCorry
  • Nutrition and ageing research
  • Data analysis in cohort studies and clinical/community - based dietary interventions 
Dr Claire McEvoy
  • Behaviour change interventions focusing on diet and/or obesity across a range of population groups
  • Obesity management
  • Preconception health for men and women - improving health status before pregnancy
Dr Laura McGowan
  • Dementia research including the role of nutrition and inflammation in neurodegeneration
  • The utility of EEG and MEG in assisting diagnostics
  • Large data analytics projects
Dr Bernadette McGuinness
  • Diabetic complications
  • Biomarker discovery
  • Stratified Medicine
Dr Gareth McKay
  • Improving oral health for care home residents
  • Exploring links between oral health and nutritional wellbeing
  • Improving care for head and neck oncology patients
Dr Gerry McKenna
  • Nutrition and prevention/management of obesity
  • Diabetes and cardiovascular disease
Dr Michelle McKinley
  • Genetic-epigenetic-transcriptomic association studies for kidney disease.
  • Multi-omic risk factors for rare disease, and common diseases with a focus in aging populations. 
  • Information and communication provision for kidney disease and rare disease(s).
Dr Amy Jayne McKnight
  • Discrete choice models
  • Secondary data analysis
  • Longitudinal data
Dr Vikki O'Neill
  • Research on administrative data related to ageing, pensions, poverty at older ages
  • Research on looked after children or children known to social services.
Dr Dermot O'Reilly
  • Translational Research 
  • Risk Factors and Biomarkers in the various dementia syndromes
Dr Peter Passmore
  • Ophthalmic image analysis
  • Diabetic retinopathy screening
  • Epidemiology of eye diseases in different populations around the world
Professor Tunde Peto
  • Physical Activity
  • Sedentary behaviour and exercise in school, workplaces or with older adults
Dr Mark Tully
  • Nutrition, particularly dietary intervention studies
  • Projects involving innovative dietary assessment and behaviour change interventions
Professor Jayne Woodside

The Wellcome-Wolfson Institute For Experimental Medicine

 

Research Opportunities

Supervisors

  • Critical care studies that include studies conducted within and after ICU; ICU survivorship; trial methodology studies
Professor Bronagh Blackwood
  • Airway Clearance
  • Exercise and rehabilitation
  • Methods for optimizing clinical trials
Professor Judy Bradley
  • Signal transduction
  • Molecular cell biology
  • Mouse models of disease and drug discovery targeting Grem1 and other proteins involved in human disease
Dr Derek Brazil
  • Epithelial biology;
  • Immunology
  • Microbiology
Dr Eric Campbell
  • Innate immunity
  • Cell and molecular biology
  • Retinal pathophysiology
Dr Mei Chen
  • Microvascular biology and disease
  • Pharmacological
  • Gene therapy-based approaches
Professor Tim Curtis
  • To study the role of the histamine four receptor in the regulation of neutrophil phagocytosis 
  • To study the role of acidic pH in the regulation of anti-microbial functions of neutrophils
Dr Karim Dib

 

Dr Yvonne Dombrowski
  • Cystic fibrosis
  • Bronchiectasis
  • Pneumonia

Dr Damian Downey

  • Harnessing inflammation for repair and regeneration in dental tissues
  • neuronal-immune cells signalling in inflammatory and neuropathic pain
  • Investigate potential links between oral bacteria, systemic inflammation and cardiovascular disease
Dr Ikhlas El Karim
  • Immunology
  • Neuroscience
  • Stem/Progenitor cell biology
  • Tissue regeneration
  • Neuroinflammation
  • Demyelinating diseases
Dr Denise Fitzgerald
  • Cardiovascular biology
  • Pathophysiology
  • Pharmacology
Dr David Grieve
  • Non-adherence in asthma
  • Stratified Medicine / Personalised medicine
  • Health informatics / Health economics

Professor Liam Heaney 

  • Host-pathogen interactions
  • vaccinology
  • pharmacology
Dr Beckie Ingram
  • Investigation of the role of MSC exosomal miRNAs in epithelial and endothelial repair in ARDS
  • The role of MSC mitochondrial transfer in lung regeneration
  • The role of apoptosis in MSC therapeutic effects in ARDS

Dr Anna Krasnodembskaya

  • Multidisciplinary environment to combine molecular, morphological and clinical approaches.
Dr Imre Lengyel
  • Biomedical informatics (translational bioinformatics and exposome informatics)
  • Integration of clinical and molecular data
  • Analysis and representation of exposome data
Dr Guillermo Lopez Campos
  • Various aspects of infection, pain and inflammation in the oral cavity and upper respiratory tract
Dr Fionnuala Lundy
  Dr Andriana Margariti
  • Cardiovascular medicine
  • Ophthalmology
  • Regenerative medicine

 Dr Denise McDonald

  • Neuroinflammation and airways disease
  • Early life influences on adult respiratory health
  • Cohort studies in Early COPD
  • Phase II/III Clinical trials in cough, asthma and COPD
Professor Lorcan McGarvey
  • Improving the diagnosis of serious infection in hospitalised patients
Dr Ronan McMullan
  • Vascular stem cell biology
  • Diabetic retinopathy
  • Diabetic vascular complications
  • Cellular senescence
  • Angiogenesis

 Dr Reinhold Medina

  • Proteomics – to identify protein-protein interactions in rhinovirus-infected cells
  • Molecular cell biology/biochemistry – to understand the role of cellular proteins in rhinovirus replication

Dr Aurelie Mousnier

  • Molecular, cellular, genetic and disease models of inflammation and inflammatory diseases 
  • Identifying novel diagnostics and new therapeutic strategies in the treatment of inflammatory diseases. 
Professor Paul Moynagh
  • Pharmacology
  • Spatiotemporal aspects of GPCR signalling
  • Pathophysiology
Dr Bianca Plouffe
  • Respiratory syncytial virus biology, pathogenesis, and vaccines.
  • Paramyxovirus vaccine vectors, in particular Sendai virus.
  • Culture and exploitation of well-differentiated primary human airway epithelium cell cultures.

 Dr Ultan Power

  • Cellular microbiology of bacterial respiratory pathogens
  • Functional genomics of bacterial virulence factors
  • Subversion of innate immune cells by infection
  • Proteomics approaches to study signalling at the pathogen-host interface
Dr Gunnar Neels Schroeder
  • Epithelial biology
  • Pathophysiology
  • Biomarkers of diseases
  • Bioinformatics
Dr Bettina Schock
  • Lung microbiome
  • Aerosol therapy in critical care
  • Prevention of post-operative pulmonary complications
  • Mechanistic studies to understand pulmonary inflammation and injury

Dr Murali Shyamsundary

 
  • MicroRNAs – their role in gene regulation and use as biomarkers
  • Transcriptomics - RNA-Seq, including single cell analysis
  • Microbial DNA sequencing
Dr David Simpson
  • Harnessing ECFCs to repair choriocapillaris during geographic atrophy
  • The role of the placental growth factor pathway in age-related retinal disease
  • Metabolic plasticity of retinal cells in ischaemia and the potential to regulate physiological angiogenesis
  • Identifying key molecular mechanisms underpinning ECFC dysfunction in diabetic microvascular disease.
  • Development of vascular stem cell therapy for ischaemic retinopathy
  • Combinatorial cell therapy for reversing tissue ischaemia
  • The potential of iPS cell technology to understand mechanisms underpinning patient responsiveness to anti-VEGF agents for diabetic macular oedema

 Professor Alan Stitt

  • Dysregulated protease activity in acute and chronic lung disease
Professor Cliff Taggart
  • Molecular mechanisms of intrinsic multi-drug antibiotic resistance
  • Biogenesis of the Gram-negative bacterial outer membrane, especially lipopolysaccharide and cell wall peptidoglycan
  • Cellular microbiology of opportunistic; Gram-negative bacterial pathogens in phagocytic cells.
Professor Miguel A. Valvano
  • Heart failure, Cardiomyopathy, Cardiac remodelling
  • Diabetes, Hypertension, Ischaemia
  • Biomarkers, Epigenetics, Fibrosis
  • Global Health, mHealth

 Dr Chris Watson

  • Innate immunity
  • Repair and regeneration
  • MiRNA function
  • Transcriptomics in the field of acute and chronic lung inflammation and disease
Dr Sinéad Weldon
  • Immunology
  • Cell and molecular biology
  • Retinal pathophysiology
  • Pharmacology
Professor Heping Xu

Centre for Medical Education

 

Research Opportunities

Supervisors

 

Professor Tim Dornan
  • Simulation based education
  • Medical Education
  • OSCEs
Professor Gerry Gormley
  • Medical education in the General Practice setting
  • Transformative learning
  • Safe care and quality improvement in healthcare
  • Novel platforms for medical education
Dr Nigel Hart
  • Medical education, using qualitative methodologies
Dr Jenny Johnston
  • Haematology

Professor Mary Frances McMullin