Opportunities

Job reference: 19/107835

Date posted: 30/09/2019

Application closing date: 30/10/2019

Salary: £33,797 to £36,914 per annum.

Job description: we are recruiting for a Postdoctoral Research Fellow with training in molecular cell biology/innate immunity/virus-host interactions/airway epithelium or in related fields for Prof. Ultan Power's group. This is part of a large Wellcome Trust Strategic award, called Breathing Together, involving 7 UK and 1 Australian institutions (http://breathingtogether.co.uk/). The successful applicant will study the relative consequences of respiratory syncytial virus (RSV) and/or aeroallergen exposure of paediatric airway epithelium derived from infants with wheeze/asthma and/or atopy compared with healthy infants.  The project was designed to generate a greater understanding of factors implicated in the development of pre-school wheeze. As airway epithelium plays a central role in determining infant responses to inhaled infections or allergens, understanding how it develops in health and disease will provide major insights into the development of wheeze/asthma. This project, therefore, seeks to determine what triggers wheeze/asthma and whether or not we can predict which infants will progress to develop disease. The successful candidate will work in partnership with members of the Power group and the wider Breathing Together team, plan and perform experiments, and will be involved in the supervision and training of junior lab members.

The successful candidate must: 

• Have or about to obtain a PhD in cell biology, innate immunity, virology, or equivalent subject
• At least 3 years recent relevant research experience to include experience ina wide range of laboratory techniques appropriate to study host/pathogen interactions, such as cell culture capabilities, fluorescent microscopy, biochemistry, and/or virology.

Informal enquiries may be directed to Dr Lindsay Broadbent via email:  l.broadbent@qub.ac.uk

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Job title: Research Fellow

Job reference: 19/107880

Date posted: 14/10/2019

Application closing date: 13/11/2019

Salary: £33,797 to £35,845 per annum.

Job description: we are recruiting for a Research Fellow to join Dr Andriana Margariti's Stem Cell biology research team and Regenerative Medicine in vascular diseases within the WWIEM. The successful candidate will work on a BHF-funded project based on endothelial cell dysfunction and blood vessels organoids in diabetes using the remarkable technology of patient specific induced pluripotent stem cells. The underlying mechanisms of endothelial cell dysfunction and blood vessels organoids will be investigated based on RNA binding proteins and the mRNA splicing machinery. This project is employing cutting edge technologies of cell reprogramming and generation of diabetic patient specific cells. Complex in vitro and in vivo models will be used to assess and restore the function of diabetic endothelial cells in vascular repair. This project holds the potential to explore novel treatments for diabetes and development of key biomarkers.

The successful candidate must: 

• Have or about to have a PhD in a biomedical field of laboratory-based research.
• At least 3 years recent relevant research experience, to include:
• - Cell culture, including experience working with stem cells 
• - Standard molecular biology techniques (eg real time PCR, western blots, staining etc.)

Informal enquiries may be directed to Dr Sophia Kelaini via email: s.kelaini@qub.ac.uk.

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