Top
Skip to Content
LOGO(small) - Queen's University Belfast
  • Our x-twitter
  • Our facebook
LOGO(large) - Queen's University Belfast

Wellcome-Wolfson Institute For Experimental Medicine

  • Home
  • Our Research
    • Research Themes
    • Find a PhD Supervisor
  • Our People
    • Key Contacts
    • Academic Staff
    • Fellows
    • Research Staff
    • Technical Staff
    • Administrative/Clerical Staff
    • Emeritus Professors
    • Opportunities
    • Visiting Students
  • Our Place
    • Facilities
    • Seminar Series
    • The Barcroft Lecture
    • The Annual Kenneth B. Fraser Memorial Symposium in Infection Biology
    • Green Impact
  • Outreach
    • Balmoral Show
    • Northern Ireland Science Festival
    • Learn@Lunch 2022-2023
    • Pint of Science
    • UNISTEM Belfast 2025
    • Apply for Work Experience
    • Research Placements and Experiences - STEM Learning
    • NI Multiple Sclerosis Research Network
  • Education and Training
    • Postgraduate Degrees
    • Masters in Biomedical & Clinical Research
    • Undergraduate Degrees
    • Summer Student Programme
    • iEngage Online Summer Student Research Programme
    • Postdoctoral Development Programme
    • Short Courses
  • News
    • WWIEM Newsletter
  • Innovation
  • Impact
  • COVID-19
  • Donate
  • Home
  • Our Research
    • Research Themes
    • Find a PhD Supervisor
  • Our People
    • Key Contacts
    • Academic Staff
    • Fellows
    • Research Staff
    • Technical Staff
    • Administrative/Clerical Staff
    • Emeritus Professors
    • Opportunities
    • Visiting Students
  • Our Place
    • Facilities
    • Seminar Series
    • The Barcroft Lecture
    • The Annual Kenneth B. Fraser Memorial Symposium in Infection Biology
    • Green Impact
  • Outreach
    • Balmoral Show
    • Northern Ireland Science Festival
    • Learn@Lunch 2022-2023
    • Pint of Science
    • UNISTEM Belfast 2025
    • Apply for Work Experience
    • Research Placements and Experiences - STEM Learning
    • NI Multiple Sclerosis Research Network
  • Education and Training
    • Postgraduate Degrees
    • Masters in Biomedical & Clinical Research
    • Undergraduate Degrees
    • Summer Student Programme
    • iEngage Online Summer Student Research Programme
    • Postdoctoral Development Programme
    • Short Courses
  • News
    • WWIEM Newsletter
  • Innovation
  • Impact
  • COVID-19
  • Donate
  • Our x-twitter
  • Our facebook
In This Section
  • WWIEM Newsletter

  • Home
  • Wellcome-Wolfson Institute For Experimental Medicine
  • News

News

Queen's researchers in €2.25m international project to tackle diabetes-related blindness

18 May, 2016

World-leading researchers from Queen’s University Belfast are among a team of scientists from the USA and Ireland who are collaborating to develop a novel treatment for diabetes-related blindness.

The new €2.25m US-Ireland R&D partnership is bringing together a unique team of scientists and clinicians to develop a gene therapy approach with the aim of potentially reversing diabetes-linked blood vessel damage to the retina – the light-sensitive tissue at the back of the eye. Ultimately, the team hopes to prevent disease progression and restore visual function.

Diabetes-related blindness, also known as diabetic retinopathy, is caused by high blood sugar levels damaging the blood vessels in the retina. This global challenge affecting more than 90 million people is one of the leading causes of ‘new’ blindness in working-age adults in the UK.

Existing therapies, such as laser treatment and monthly injections of drugs into the eye, are not effective for all patients and carry significant side effects and cost implications for the NHS.

The research team is planning to overcome these limitations by developing a gene therapy approach based on the use of adeno-associated viruses (AAV) which insert genetic material at a specific site. This will enable long‑term delivery of a protein, called COMP-Ang1, to the retina. The researchers have previously discovered that this protein can protect the retina from damage during diabetes, but precisely how it does this remains unclear.  

The team will investigate how COMP-Ang1 prevents inflammation, leakage from blood vessels and improves the function of the retina. They will also investigate the ability of COMP-Ang1 to enhance a stem cell therapy which the team at Queen’s has been developing over several years. Ultimately, it is hoped that COMP-Ang1 will facilitate the reversal and repair of diabetic damage to the retina.

Dr Tim Curtis, from the Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University, said: “During diabetes, blood flow to the retina is impaired and this is believed to trigger the development of diabetic retinopathy. Our aim is to examine whether COMP-Ang1 treatment is capable of preventing or reversing diabetic retinopathy by improving blood flow and vascular repair in the retina. Queen’s researchers are established leaders in diabetic retinopathy and we are delighted to be part of a leading international consortium tackling one of the major health challenges facing us today.”

At the University of Utah, researchers will ascertain how the drug prevents inflammation in diabetic patients, using the smallest possible drug dose to achieve optimal long-term effect while minimising side-effects of toxicity. The researchers at Dublin City University will advance our knowledge of therapeutic viruses to ensure their improved efficiency for delivery into the eye.

Research funding of €2.25m was received through the US-Ireland R&D Partnership Programme.  This research partnership is a unique arrangement involving funding agencies in the USA, the Republic of Ireland and Northern Ireland which combine resources to enable the best researchers from Ireland and the USA to work together on research to address critical issues and generate valuable discoveries that will impact on patient care.

Dr Janice Bailie, Assistant Director of the Public Health Agency’s HSC R&D Division, which is funding the Northern Ireland part of this project with support from the Medical Research Council, said: “We are delighted to be funding this project which will tackle an important problem affecting people with diabetes. We expect that the outcomes from this international research will lead to significant advances in the treatment of patients with diabetes-related blindness in the UK, Ireland and beyond.”

The five-year programme will commence in April 2016.

Share
Latest News
  • Queen’s academic awarded prestigious Professorship
    22 May, 2024
  • Professor Pascale Cossart of Institut Pasteur Receives Barcroft 2020 Medal
    4 May, 2022
  • Resource launched illustrating COVID-19 variants across Northern Ireland
    8 February, 2022
  • New research will focus on repurposing existing anti-viral therapies to treat patients with COVID-19
    31 January, 2022
  • Non-invasive ventilation for COVID-19 patients isn’t linked to heightened infection risk
    5 November, 2021
News
  • WWIEM Newsletter
QUB Logo
Contact Us

Wellcome-Wolfson Institute For Experimental Medicine

School of Medicine, Dentistry and Biomedical Sciences
Queen's University Belfast
97 Lisburn Road
Belfast
BT9 7BL

Tel: (+44) 028 9097 1643
Email: wwiem@qub.ac.uk

Quick Links

  • Home
  • Our Research
  • Our People
  • Our Place
  • Education and Training
  • Opportunities

 

© Queen's University Belfast 2024
  • Privacy and cookies
  • Website accessibility
  • Freedom of information
  • Modern slavery statement
  • Equality, Diversity and Inclusion
  • University Policies and Procedures
Information
  • Privacy and cookies
  • Website accessibility
  • Freedom of information
  • Modern slavery statement
  • Equality, Diversity and Inclusion
  • University Policies and Procedures

© Queen's University Belfast 2024

Manage cookies