Top Skip to main content
Skip to Content
LOGO(small) - Queen's University Belfast
  • Our facebook
  • Our x-twitter
  • Our linkedin
  • Our youtube
LOGO(large) - Queen's University Belfast

School of

Biological Sciences

  • Home
  • Study
    • Undergraduate Courses
    • Postgraduate Taught Courses
    • Fieldwork Opportunities
    • Scholarships and Awards
    • Course Accreditations
  • Research
    • Postgraduate Research
    • PhD Opportunities
    • Find a PhD Supervisor
    • Research Impact
    • Research Culture
    • Centre of Excellence for Agri-Food Microbiomes (CEAM)
  • International
    • Partnerships
    • Students
    • Opportunities
  • Employability
    • Business Engagement
    • Employer Testimonials
    • Undergraduate Careers & Placements by Sector
    • Postgraduate Careers & Placements by Sector
    • Student Experiences
    • Alumni Profiles
    • News, Programmes and Events
  • About
    • Facilities
    • Nursing Mothers and Parents’ Room & Quiet Room
    • Athena SWAN
    • Laboratory Efficiency Assessment Framework (LEAF)
    • Applying for Honorary and Visiting Titles
  • People
    • Key Contacts
    • School Management Committee
    • Academic Staff
    • Professional Services Staff
    • Technical Staff
    • Research Staff
    • Honorary Staff
  • Staff Profiles
    • Dr Connor Bamford
    • Prof Lisa Connolly
    • Dr Lucia Lombardi
    • Prof Aaron Maule
    • Dr Linda Oyama
    • Prof Paulo Prodöhl
    • Dr Rachel Wheatley
  • News
  • Graduation
  • Events
  • Home
  • Study
    • Undergraduate Courses
    • Postgraduate Taught Courses
    • Fieldwork Opportunities
    • Scholarships and Awards
    • Course Accreditations
  • Research
    • Postgraduate Research
    • PhD Opportunities
    • Find a PhD Supervisor
    • Research Impact
    • Research Culture
    • Centre of Excellence for Agri-Food Microbiomes (CEAM)
  • International
    • Partnerships
    • Students
    • Opportunities
  • Employability
    • Business Engagement
    • Employer Testimonials
    • Undergraduate Careers & Placements by Sector
    • Postgraduate Careers & Placements by Sector
    • Student Experiences
    • Alumni Profiles
    • News, Programmes and Events
  • About
    • Facilities
    • Nursing Mothers and Parents’ Room & Quiet Room
    • Athena SWAN
    • Laboratory Efficiency Assessment Framework (LEAF)
    • Applying for Honorary and Visiting Titles
  • People
    • Key Contacts
    • School Management Committee
    • Academic Staff
    • Professional Services Staff
    • Technical Staff
    • Research Staff
    • Honorary Staff
  • Staff Profiles
    • Dr Connor Bamford
    • Prof Lisa Connolly
    • Dr Lucia Lombardi
    • Prof Aaron Maule
    • Dr Linda Oyama
    • Prof Paulo Prodöhl
    • Dr Rachel Wheatley
  • News
  • Graduation
  • Events
  • Our facebook
  • Our x-twitter
  • Our linkedin
  • Our youtube
In This Section

  • Home
  • School of Biological Sciences
  • News
  • Archive

Archive

Zebrafish could help humans reach Mars!

21 May, 2021

Researchers at the School of Biological Sciences and IGFS used zebrafish to investigate if a form of hibernation, known as induced torpor, could protect against radiation - one of the biggest challenges facing astronauts.

Hibernation is a physiological condition found in many species that protects them against harsh conditions, such as food scarcity and low environmental temperatures.

Replicating hibernation may therefore protect astronauts against the harsh conditions of space flight, which include challenges such as radiation exposure, bone and muscle wastage, advanced ageing and vascular problems. The researchers believe if astronauts hibernate on their journey, those difficulties may be solved.

The research has been published in the journal MDPI Cells.

Professor Gary Hardiman from IGFS and senior author, said: “NASA plans to return to the Moon and onward to Mars in the coming years. Recent technological advancements have made space travel more accessible, however, long-term space travel is incredibly detrimental to human health.

“We set out to determine if induced torpor is a viable countermeasure to the harmful effects of spaceflight. If humans could replicate a similar model of hibernation we have observed in the zebrafish, it could increase our chances of making humans a spacefaring species. For example, it would lead to reduced brain function which would cut down on psychological stress. The change to their metabolism would stop them requiring food, oxygen or water and there is a possibility it would protect their muscles from wasting due to the effects caused by radiation and microgravity.”

To conduct their study, the researchers exposed zebrafish to radiation like what would be experienced on a six-month journey to Mars. The researchers found that this radiation caused signatures of oxidative stress, stress hormone signaling and halting of the cell cycle within the zebrafish.

The researchers then induced torpor in a second group of zebrafish which were then exposed to the same dose of radiation and analysed their gene expression patterns to assess the protective effects during this induced state of physical or mental inactivity.

The results found that torpor lowered the metabolic rate within the zebrafish and created a radioprotective effect, protecting against the harmful effects of radiation.

Thomas Cahill, PhD student from IGFS and co-first author of the research, said: “Our results reveal that whilst in induced torpor, the zebrafish showed that a reduction in metabolism and oxygen concentration in cells promotes less oxidative stress and greater resistance to radiation.

"These insights into how a reduction in metabolic rate can offer protection from radiation exposure and could help humans achieve a similar kind of hibernation, counter measuring the damage they currently face during spaceflight.”

The research was funded by a US NASA EPSCoR award and a Department for the Economy (DfE) Research Studentship and was carried out by researchers including Dr Willian A da Silveira and Ms Hao Wang from SOBS/IGFS and Dr Ian Overton from The Patrick G Johnston Centre for Cancer Research at Queen’s.

Investigators from the USA included Drs Ludivine Renaud, Tucker Williamson and Sherine SL Chan from The Medical University of South Carolina (MUSC) and Dr. Dongjun Chung from Ohio State University, Columbus.​

Share
Latest News
  • Research demonstrates how plastics threaten biodiversity of marine life
    13 October, 2021
  • New species named by SBS expert to be protected in sustainability project
    12 October, 2021
  • Queen’s University exploring willow in race to net zero
    7 October, 2021
  • SBS-led research reveals link between gut microbiome and flavonoids in improving blood pressure
    24 August, 2021
  • SBS & IGFS researchers join European climate-change project
    18 August, 2021
QUB Logo
Contact Us

School of Biological Sciences

Queen's University Belfast
School of Biological Sciences
19 Chlorine Gardens
Belfast BT9 5DL
Northern Ireland

GET DIRECTIONS

  • Phone: +44 (0)28 9097 5787
  • Email: sbsigfsoffice@qub.ac.uk 

Quick Links

  • Home
  • Study
  • Research
  • People
© Queen's University Belfast 2025
Privacy and cookies
Website accessibility
Freedom of information
Modern slavery statement
Equality, Diversity and Inclusion
University Policies and Procedures
Manage cookies