Research Interests
Open to PhD applications in the field of the biology, characterisation and therapeutic targeting of mammalian and microbial proteases.
- USP17 as a therapeutic target in cancer
- Targeting bacterial proteases as an antimicrobial strategy
Current Research Opportunities
Public outreach & key achievements
-
USP17 Required for Clathrin Mediated Endocytosis of Epidermal Growth Factor Receptor
-
A Novel RCE1 Isoform is required for H-Ras Plasma Membrane Localisation
- USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells
Research students
PhD Title | Identifying drug targets to combat Acinetobacter baumannii infections? |
Name | Bronagh Elmore |
Country | UK |
Year of Study | 2019-2022 |
PhD Title | Manipulating endocytosis to facilitate drug uptake and delivery |
Name | Alhareth Alsa’d |
Country | Jordan |
Year of Study | 2019-2022 |
PhD Title |
Jonathan Burden
|
Name |
USP17 as a potential cancer therapeutic target
|
Country |
2020-2023
|
Year of Study |
United Kingdom
|
Alumni: Where are they now
PhD Title | Therapeutic evaluation of an immunomodulatory nanoparticle in Acute Respiratory Distress Syndrome |
Name | Dr Michelle Greene |
Year of Study | 2011-2015 |
Country | Country: United Kingdom |
Current Position | Postdoctoral Fellow, Patrick G. Johnston Centre for Cancer Research, Queen’s University Belfast, UK |
PhD Title | The role of the deubiquitinating enzyme USP17 in endocytosis and the regulation of Ras converting enzyme 1 activity. |
Name | Dr Jakub Jaworski |
Year of Study | 2010-2013 |
Country | Poland |
Current Position | Principal Scientist, Immunocore Ltd, Oxford, UK |
PhD Title | The role of USP17 in EGFR signaling and as a potential novel target for therapy in colorectal cancer |
Name | Aidan McCann |
Year of Study | 2015-2018 |
Country | UK |
Current Position | Senior Scientist, Almac Discovery, Belfast, UK |