Research Interests

Open to PhD applications in the field of preclinical oral dose development including targeted

• Drug delivery
• Amorphous solid dispersions
• Hot-Melt Extrusion
• 3D printing
• Continuous processing and PAT.

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Current Research Opportunities

• Developing magneto-electric nanoparticles for advanced drug delivery of therapeutic agents for the treatment of neurological tuberculosis and HIV
• Development of Solid-state Therapeutic Protein Formulations for Oral Delivery via Advanced and Continuous Manufacturing Technologies
• Development of Variable Dose Combination Products Using FDM 3D Printing
• Development of antifungal nanotherapeutics containing AmB+ drug combinations using an advanced continuous manufacturing technology
• Development of paediatric-centred anti-malaria nanotherapeutic formulations using an advanced continuous manufacturing technology
• Development of Innovative Diabetic Foot Ulcer Treatment Strategies using Photodynamic Therapy + Combination Delivery Systems
• The Development of Innovative Indwelling Medical Devices containing Biosensor Technology

Public outreach & key achievements

• Recent work recognising ‘excellence in Science’ included in The Royal Society Trustees’ Report, involves the manufacture of solid dispersions and co-crystals to improve the dissolution rate of poorly water-soluble drugs, one of the major challenges in dosage form development.

Research students

Name: Zian Zhang
PhD title: Manufacture of Multi-Drug Formulations using Melt Extrusion and FDM-3D printing Technologies
Years of Study: 2
Country: China

Name: Dijia Liu
PhD title: Development of Patient-Centric Formulation Strategies using Hot Melt Extrusion
Years of Study: 1
Country: China

Name: Jacob Yang
PhD title: Manufacture of Amorphous Solid Dispsersions using HME
Years of Study: 3
Country: China

Name: Daniel Sedough-Abbasian
PhD title: Development of lipid-based nanocarriers using melt extrusion for oral peptide delivery
Years of Study: 1
Country: UK

Alumni: Where are they now

Name: Zhai Hui
PhD title: Using Fluidised Bed Hot Melt Granualtion as a Novel Pharmaceutical Technology to Manufacture Solid Oral Dosage Forms
Years of Study: 3
Country: China
Current position: R&D Director Beijing Pharma

Name: Colette Lagan
PhD title: Continuous Manufacturing for Production of Drug Enabled Formulations of Poorly Water-soluble Drugs
Years of Study: 4 – including industrial placement
Country: UK
Current position: Process Development Engineer Amgen

Name: Dan Margetson
PhD Title:
Years of Study: 7 Years – Part-Time through GSK
Country: UK
Current Position: Director – Manfacturing Science and Technology, Theramex

 

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• Faculty of Medicine, Health & Life Sciences

• School of Pharmacy

• Materials and Advanced Technologies for Healthcare