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  • Research in the School of Medicine, Dentistry and Biomedical Sciences
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Find a PhD Supervisor

Professor Paul Harkin

School of Medicine, Dentistry and Biomedical Sciences

Professor Paul Harkin

School of Medicine, Dentistry and Biomedical Sciences

Professor Harkin’s research is focused on understanding the impact of mutations within the BRCA1 gene in the development and treatment of hereditary breast and ovarian cancer.

We are using a number of complementary strategies to investigate the role played by BRCA1 in both DNA damage repair and transcriptional regulation. We were the first lab to identify a novel BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability following DNA damage.

Contact info

  • View Academic Profile
  • askmhls@qub.ac.uk
  • +44 (0)28 9097 2938

Research Interests

Open to PhD applications in the field of

  • DNA damage repair
  • Transcriptional regulation
  • Mechanisms of sensitivity/resistance to DNA damage based therapeutics

Make a PhD enquiry


Public outreach & key achievements

  • Cancer Discovery (journal) - editorial "BRCA1-MEDIATED mRNA SPLICING MAINTAINS GENOME STABILITY"
  • The Belfast Telegraph - feature story "Queen's University Belfast breakthrough in bid to combat a killer cancer gene"
  • The Mirror - feature story "Researchers in Northern Ireland make huge breakthrough in fight against breast and ovarian cancer"

Research students

PhD Title The molecular and genetic characterisation of contralateral breast cancer
Country United Kingdom
   

 


Alumni: Where are they now

PhD Title Functional analysis of BRCA1
Country United Kingdom
Current Position McClay Professor of Experimental Medicine, QUB and Vice President of biomarker discovery at Almac Diagnostics 
   
PhD Title Role played by BRCA1 in mRNA splicing
Country Estonia
Current Position
Research Fellow in Genetics at Livingston Lab, Dana Farber Cancer Institute, Harvard Medical School

 


Discover More

  • Faculty of Medicine, Health and Life Sciences

  • School of Medicine, Dentistry and Biomedical Sciences
  • The Patrick G Johnston Centre for Cancer Research
  • Institute for Health Sciences


Postgraduate research
Apply now
Your postgraduate experience
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