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Find a PhD Supervisor

Dr Konstantin Panov

School of Biological Sciences
Lanyon

Dr Konstantin Panov

School of Biological Sciences

My main research interest are centred around the biochemistry of human RNA Polymerase I (Pol-I) transcription machinery, molecular and cellular mechanisms involved in the regulation of ribosomal RNA (rRNA) synthesis including signal transduction and epigenetic mechanisms, and discovery of novel drugs targeting rRNA transcription.

The level of ribosomal RNA synthesis by Pol-I is rate-limiting to ribosome biogenesis and therefore has a major influence on the cellular capacity for protein production, making Pol-I transcription fundamental to life. Elevated levels of rRNA synthesis are required to support the unrestrained proliferation of cancer cells making rRNA synthesis a valid target for anticancer therapy as well as providing opportunities for the diagnosis of cancer. On the other hand, drugs promoting rRNA synthesis might be useful for stimulation of cell growth and proliferation in cell-replacement therapy strategies.

Contact info

  • View Academic Profile
  • askmhls@qub.ac.uk
  • +44 (0)28 9097 2119

Research Interests

Open to PhD applications in the field of

  • Transcription
  • Epigenetic
  • Signalling
  • Cancer

Make a PhD enquiry


Current Research Opportunities

  • The role of the histone lysine demethylase KDM4A in post-stress recovery and its utility as a target in breast and prostate cancer
  • Development of novel approaches to study changes in chromatin structure and investigation of the role of rDNA chromatin in malignant transformation
  • Investigation of the mechanism of accrued resistance to Pol I inhibitors in blood cancers
  • How the interactome defines the biological activity of members of the KDM4A subfamily of histone demethylases.

Research students

PhD Title rRNA synthesis and regulation as potential anticancer target in breast cancer.
   

 


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