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Professor Aaron Maule

School of Biological Sciences

Professor Aaron Maule

School of Biological Sciences

We work to reconcile omics data with biological functions in the context of parasite disease control.  Our focus is on the development of novel drugs / vaccines for parasites through the discovery and validation of new targets for these interventions. 

We interrogate pathways and processes that control parasite behaviour (parasite nervous systems and muscles) as well as their growth and development (parasite stem cells) to uncover these new targets.  Vaccine candidates encompass virulence proteins involved in the host-parasite interaction as well as novel, parasite-specific proteins lacking known homologues. 

We develop functional genomics tools for parasites, facilitating the delineation of gene function and the exposure of new control targets from diverse omics datasets.  Work also encompasses the translation of in vitro gene silencing methods for both the in vivo assessment of target value and for the direct control of parasitic worms.

Contact info

  • View Academic Profile
  • askmhls@qub.ac.uk
  • +44 (0)28 9097 2059, +44 (0)28 9097 2196, +44 (0)28 9097 2897

Research Interests

Open to PhD applications in the field of

  • Biological/veterinary/medical science
  • Infectious disease
  • Parasitology
  • Functional genomics
  • Exploitation and development of new ‘omics’ technologies for drug discovery/disease control. 

Make a PhD enquiry


Public outreach & key achievements

  • Significant and sustained engagement with global pharmaceutical companies engaged in the development of new drugs for parasite control.
  • Awarded C.A Wright Medal by the British Society for Parasitology (Salford, England, 2004). 
  • Winner of Bueding von Brand Memorial award from the American Society of Parasitologists (Arlington, Texas, USA, 2008)
  • Elected to Membership of the Royal Irish Academy, 2012.  

Research students

PhD Title Understanding the mechanisms of parasite drug resistance
   
PhD Title   Exploiting parasite neurobiology for disease control 
   
PhD Title  Studies on the biology of stem cells in parasites
   
PhD Title Liver fluke stem cell dynamics and parasite growth/development

 


Alumni: Where are they now

Current Position  Assistant Professor, Iowa State University, College of Veterinary Medicine, USA
   
Current Position  Associate Professor, Iowa State University, College of Veterinary Medicine, USA
   
Current Position  Senior Lecturer, Biological Sciences, Institute for Global Food Security, Queen’s University Belfast, UK
   
Current Position  Lecturer, Biological Sciences, Institute for Global Food Security, Queen’s University Belfast, UK
   

 

 


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School of Biological Sciences

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School of Biological Sciences
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Belfast BT9 5DL
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