Dr Tribello’s research is in the field of classical molecular simulation. More specifically he works with methods that ensure rare events such as chemical reactions, protein folding and nucleation happen in short simulations. 

He is one of the core developers of the PLUMED plugin for enhanced sampling and was also a developer of the sketch-map algorithm for dimensionality reduction. His research has attracted funding from a number of sources including the Engineering and Physical Sciences Research Council and the European Union.