Dr Sarri works on developing and using ultra-intense lasers to generate exotic states of matter and study their unique properties. In particular, he works on the next generation of ultra-compact particle accelerators, laboratory astrophysics(reproducing, in the labroatory, conditions found close to black-holes and massive stars), generation of high-quality x-ray, gamma-ray, and positron sources, and high-field quantum electrodynamics.

He is a member of European programmes ELI, EuPRAXIA, ALEGRO, PWASC, EuroNNAC, ARIES.