- N. Ireland Barrett’s Oesophagus Register (NIBR)
- Colorectal Polyps
- Northern Ireland Endometrial Hyperplasia register
- PSA Database
N. Ireland Barrett’s Oesophagus (NIBR)
The Northern Ireland Barrett’s oesophagus Register, led by Professor Liam Murray, is one of the largest population-based registers of Barrett’s worldwide, and now includes information on >13,000 incident diagnoses in Northern Ireland since 1993. Barrett’s oesophagus is a pre-cursor condition for the cancer, oesophageal adenocarcinoma. Key publications from this work have demonstrated that:
- Cancer progression risk in Barrett’s is lower than previously thought
- Barrett’s incidence rates have increased over and above those of endoscopy and oesophageal biopsy rates, indicating the rising incidence is not an artefact of changes in clinical practice
- Tobacco smoking and having a Barrett’s ulcer are associated with a two-fold increased risk of progression from Barrett’s to oesophageal adenocarcinoma
- Only 7% of oesophageal adenocarcinoma patients actually had their Barrett’s diagnosed before their cancer
- As part of a multi-centre collaborative study, a panel of biomarkers may predict those at highest risk of progression from Barrett’s oesophagus to oesophageal adenocarcinoma
The Colorectal Polyp Register includes information on all polyp diagnoses since 2000 in Northern Ireland (Joint PIs: Drs Marie Cantwell/Anna Gavin). This resource has been used to investigate the risk of cancer in relation to type of polyps and findings show that elevated cancer risk remains in patients who have undergone polypectomy. A joint molecular epidemiology study with Vanderbilt University, TN, USA, is ongoing using this resource to identify biomarkers for advanced recurrent adenomas.
Funding sources: Cancer Focus Northern Ireland.
Northern Ireland Endometrial Hyperplasia register
This new project aims to establish a population-based register of Endometrial Hyperplasia cases within the Northern Ireland Cancer Registry (PI: Dr Helen Coleman). The register will improve our understanding of the prevalence of concurrent Endometrial Hyperplasia and cancer diagnoses, and allow estimations of cancer risk in Endometrial Hyperplasia cases who do not undergo hysterectomy. The results will allow women to make informed treatment choices following an Endometrial Hyperplasia diagnosis.
Funding sources: Queen’s University Belfast International PhD Studentship.
The N. Ireland Cancer Registry also hold a database on patients PSA test levels. This database is a population-based database of all PSA tests performed in NI biochemistry laboratories. The men on the database have their information linked to whether they have had a biopsy or were diagnosed with prostate cancer. Consequently, it is a valuable research resource for understanding the relationship between PSA levels in men’s blood and their risk of developing benign prostatic disease and/or malignant prostate cancer. PSA testing as a screening method for prostate cancer is highly controversial, and this population-based resource is capable of contributing to this international debate.