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Find a PhD Supervisor

Dr Anna Krasnodembskaya

School of Medicine, Dentistry and Biomedical Sciences
Dr Anna Krasnodembskaya

Dr Anna Krasnodembskaya

School of Medicine, Dentistry and Biomedical Sciences

Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSCs)-derived extracellular vesicles (EVs) with the goal of development of EV-therapeutics for respiratory diseases and novel ex vivo models of human lung tissue. 

Our central goal is to understand how EVs work in the context of the injury microenvironment, how EVs modulate reparative capacities of the host cells, and if we can enhance EV therapeutic potential through modification.  More recently, we developed novel human lung organoid model, which allows us to better study mechanisms of disease and test therapies; further optimisation of this model can be an exciting topic for potential PhD projects. 

Contact info

  • View Academic Profile
  • askmhls@qub.ac.uk
  • +44 (0)28 9097 6386

Research Interests

Open to PhD applications in the field of:

  • Therapeutic potential of MSC extracellular vesicles
  • Approaches to MSC EV engineering
  • Mitochondria based therapeutics for lung diseases
  • Lung organoids

Make a PhD enquiry


Current Research Opportunities

  • Exploration of the impact of aging and senescence on angiocrine functions of pulmonary endothelium and therapeutic potential of cell based therapies
  • Exploration of the impact of aging and senescence on angiocrine functions of pulmonary endothelium and therapeutic potential of cell based therapies
  • Investigation of the ability of Extracellular Vesicles derived from Mesenchymal Stromal Cells to promote alveolar epithelial regeneration in ARDS
  • Exploration of therapeutic potential of MSC mitochondria transplantation in the pre-clinical models of Acute Respiratory Distress Syndrome
  • Development of an organoid model of human distal lung with perfusable vasculature to study lung regeneration

Public outreach & key achievements

  • 2017 STEM CELLS Young Investigator Award Winner: Anna D. Krasnodembskaya

  • DNA of Innovation Vol.5


Research students

PhD Title Development of an organoid model of human distal lung with perfusable vasculature to study lung regeneration
Country Jordan
   
PhD Title Tractable human distal organoid model as a new efficient tool to study mesenchymal-epithelial interactions in COPD
Country United Kingdom
   
PhD Title Stem cells exosomes as regulators of neuronal signalling and dental pain
Country Jordan

 


Alumni: Where are they now

PhD Title Role of SOCS proteins in Mesenchymal Stem Cells’ modulation of macrophages in Acute Respiratory Distress Syndrome
Country China
Current Position Attending Physician at Shanghai Pulmonary Hospital, China
   
PhD Title Human Mesenchymal Stromal Cell Regulation of Pulmonary Macrophage Populations in the Acute Respiratory Distress Syndrome
Country United Kingdom
Current Position Research and Development Scientist at XENOBICS LTD

 

 


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  • Faculty of Medicine, Health and Life Sciences

  • School of Medicine, Dentistry and Biomedical Sciences
  • Wellcome-Wolfson Institute For Experimental Medicine

     


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