Professor Aaron Maule
We work to reconcile omics data with biological functions in the context of parasite disease control. Our focus is on the development of novel drugs / vaccines for parasites through the discovery and validation of new targets for these interventions.
We interrogate pathways and processes that control parasite behaviour (parasite nervous systems and muscles) as well as their growth and development (parasite stem cells) to uncover these new targets. Vaccine candidates encompass virulence proteins involved in the host-parasite interaction as well as novel, parasite-specific proteins lacking known homologues.
We develop functional genomics tools for parasites, facilitating the delineation of gene function and the exposure of new control targets from diverse omics datasets. Work also encompasses the translation of in vitro gene silencing methods for both the in vivo assessment of target value and for the direct control of parasitic worms.Find out more
Open to PhD applications from those with at least a 2.1 degree (or equivalent) in the biological/veterinary/medical sciences and interested in infectious disease, parasitology, functional genomics and the exploitation and development of new ‘omics’ technologies for drug discovery/disease control.
Phd Title: Understanding the mechanisms of parasite drug resistance
Name: Nathan Clarke
Phd Title: Exploiting parasite neurobiology for disease control
Name: Duncan Wells
Phd Title: Studies on the biology of stem cells in parasites
Name: Matt Evans
Phd Title: Liver fluke stem cell dynamics and parasite growth/development
Name: Erica Gardiner
Alumni: where are they now?
Current position: - Assistant Professor, Iowa State University, College of Veterinary Medicine, USA
Current position: Associate Professor, Iowa State University, College of Veterinary Medicine, USA
Current position: Senior Lecturer, Biological Sciences, Institute for Global Food Security, Queen’s University Belfast, UK
Lecturer, Biological Sciences, Institute for Global Food Security, Queen’s University Belfast, UK
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