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  • Research in the School of Medicine, Dentistry and Biomedical Sciences
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Find a PhD Supervisor

Dr Bettina Schock

School of Medicine, Dentistry and Biomedical Sciences

Dr Bettina Schock

School of Medicine, Dentistry and Biomedical Sciences

The innate immune system in the lung is the first defense mechanism against air-born pathogens like bacteria and viruses) and particles. The response is highly regulated to ensure timely repair and resolution of the inflammatory response. Our research focuses on the negative regulator of inflammation, called A20. A20 is significantly lower in chronic airway diseases such as Cystic Fibrosis, asthma and pulmonary fibrosis and we are investigating several regulators of A20 and identify drugs (drug repurposing) to normalize expression and function of this key protein in airway inflammation buy addressing transcriptional repressors/activators, microRNA and glucose metabolism.

Contact info

  • View Academic Profile
  • askmhls@qub.ac.uk
  • +44 (0)28 9097 2258, +44 (0)28 906 32731

Research Interests

Open to PhD applications in the field of

  • Epithelial biology and pathobiology – to understand and modify innate inflammatory responses of the epithelial using drug repurposing
  • Bioinformatics and computer-learning - to model the complexity of gene interactions involved in chronic inflammation
  • Biomarkers of diseases

Make a PhD enquiry


Current Research Opportunities

  • Modulating the A20-DREAM axis in inflammation by drug repurposing

Public outreach & key achievements

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932930/ Proc Natl Acad Sci U S A. 2016 Jun 28; 113(26): E3725–E3734. Published online 2016 Jun 10. doi: 10.1073/pnas.1520289113 PNAS Plus - Immunology and Inflammation Connectivity mapping (ssCMap) to predict A20-inducing drugs and their antiinflammatory action in cystic fibrosis Beth Malcomson, Hollie Wilson, Eleonora Veglia, Gayathri Thillaiyampalam, Ruth Barsden, Shauna Donegan, Amal El Banna, Joseph S. Elborn, Madeleine Ennis, Catriona Kelly, Shu-Dong Zhang, and Bettina C. Schock
  2. Committee member of the British Association for Lung Research (BALR): https://www.balr.co.uk/ The community for all types of respiratory scientists, from basic to clinical providing a platform to exchange ideas, create collaborations, and further pulmonary research.
  3. Outreach: Work with NICHS to publicly engage with stakeholders, involved NICHS support groups in our student teaching. We successfully host students from the South Eastern Regional College. Regular outreach activities involve engagement with young people to wake their enthusiasm for research.
  4. Students are regularly successful in obtaining summer studentships https://www.cysticfibrosis.org.uk/the-work-we-do/research/support-for-researchers/apply-for-funding/summer-studentships  https://bloomfieldcollegiate.org.uk/achievements/nuffield-bursary-presentation/ 

Alumni: Where are they now

PhD Title The Effects of Surfactant on the Biophysical Properties of sputum, Inflammation and injury in Cystic Fibrosis
Country UK
Current Position  Quality Management System lead specialist for Europe at Stryker
   
PhD Title  The role of Prevotella spp. in host-pathogen interactions in Cystic Fibrosis
Country  UK
Current Position  Postdoctoral Researcher at University of Cambridge / GSK
   

 

 


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  • Faculty of Medicine, Health and Life Sciences

  • School of Medicine, Dentistry and Biomedical Sciences

  • Wellcome-Wolfson Institute For Experimental Medicine

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