Dr Grieve's research programme is focused on investigating mechanisms underlying cardiovascular remodelling and dysfunction, with a particular interest in the role of reactive oxygen species, novel peptide hormones, endothelial progenitor cells, and the influence of diabetes.

His group employs a wide range of laboratory techniques, from in vivo physiology to molecular biology and clinical validation, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated towards therapeutic benefit.