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  • Research in the School of Medicine, Dentistry and Biomedical Sciences
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Find a PhD Supervisor

Dr Effie Kostareli

School of Medicine, Dentistry and Biomedical Sciences
Effie Kostareli

Dr Effie Kostareli

School of Medicine, Dentistry and Biomedical Sciences

Understanding the molecular mechanisms underlying treatment failure in chronic diseases such as leukaemia is an essential biological question with important clinical impact. In the last years, we have performed high throughput characterization of the enhancer landscape in Chronic Lymphocytic Leukaemia upon BTK inhibitory treatment aiming at shedding lights into Ibrutinib-treatment resistance mechanisms beyond the well-described mutations. Next, our lab research mission is to: i) investigate the role of key enhancers and transcription factors as major modulators of the transcriptional landscape in immune cells ii) defining the molecular and epigenomic feature of normal, autoimmune and. malignant B -cell of diverse maturation status in the presence of 1st and 2nd generation targeted therapeutic agents.

Contact info

  • View Academic Profile
  • askmhls@qub.ac.uk
  • +44 (0)28 9097 6475
  • @kostareli

Research Interests

Open to PhD applications in the field of

  • Epigenetic mechanisms in Leukaemia and Lymphoma
  • BTK signalling and epigenetic regulation in autoimmune disorders
  • Epigenetic and transcriptional dynamics in immune cells upon infection

Make a PhD enquiry


Public outreach & key achievements

  • Enhancer landscape in CLL upon BTK inhibition - Youtube video
  • AMS Springboard Round 5 Awardee
  • Top abstract Award by BSH -COST Action MC substitute
  • International Nucleome Consortium
  • Onassis Fellow Alumni association
  • Educational Research interests and Outreach activities related to Transferable Skills development for Biomedical Scientists.

Discover More

  • Faculty of Medicine, Health and Life Sciences
  • School of Medicine, Dentistry and Biomedical Sciences
  • Wellcome-Wolfson Institute For Experimental Medicine
  • ORCID profile

Postgraduate research
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