Research interests focus on biomarker discovery including identification of (epi)genetic and risk factors associated with diabetic kidney disease, diabetes, dementia and other chronic diseases with a microvascular component. Other research interests include nutrition related risk associated with dementia and the underlying genetics of Age-related Macular Degeneration (AMD). Ongoing investigations include genetic and epigenetic associations with socioeconomic status, serum levels of vitamin E, retinal microvascular parameters and their influence on cognition and renal outcomes.