Clinical assessment and mechanisms of severe asthma including management of poor adherence to therapy and disease stratification to deliver personalised therapeutics in severe asthma. I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK ) which aims to deliver  early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners. We also have programmes in use of routine health informatics and clinical registries and health economics.