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Femtosecond radiobiology with very high energy electron beams

School of Mathematics and Physics | PHD
Funding
Funded
Reference Number
2025/004/PHY
Application Deadline
7 February 2025
Start Date
1 October 2025

Overview

A fundamental understanding of biological response to ionising radiation requires disentangling an intricate web of processes and mechanisms, typically spanning more than twenty orders of magnitude in time, starting with ionisation and the generation and diffusion of radicals (from a few to hundreds of femtoseconds after irradiation), through the chemical reactions inducing DNA damage and repair (from picoseconds up to minutes after irradiation), and ending with the macroscopic effects induced by the biological response of the cells and tissues (emerging even years after irradiation) [1]. Within this complex and structured response, the primary role of radiation is typically completed within femtoseconds after entering the cells, mainly by inducing ionisation and production of radicals. Protracted irradiation implies that considerable energy deposition still occurs during the subsequent biomolecular damage and repair mechanisms. Radiation can thus significantly interfere with signalling channels and repair processes; for example, it is known that radiation delivered after the solvation of the electron (>500 fs) can induce its excitation, thus altering its reactivity [2]. This is a known issue in radiotherapy that cannot be addressed with conventional methods and it has been highlighted by the international research community as a key area of research [3].

To experimentally decouple physical response from secondary effects of radiation, it is necessary to develop radiation sources able to deliver Gy-scale doses in a single delivery over femtosecond timescales. In a series of pioneering experiments in collaboration with the Patrick G. Johnston Centre for Cancer Research (PGJCCR) at QUB and the National Physical Laboratory (NPL), we demonstrated that such doses can be delivered by electron beams accelerated by high-power lasers [4,5] reaching unprecedented dose-rates in excess of 1013 Gy/s. Our proof-of-concept demonstration has already provided intriguing hints of significantly different biological response of cells, including a high relative biological effectiveness and a reduction in tumour radioresistance [5], effects that are not observed at picosecond timescales [6,7].

Following on these exciting preliminary results, we have partnered with the Istituto Nazionale di Ottica (INO) in Italy, to carry out the first systematic and detailed study of the in-vitro response of biological cells to radiation delivered by plasma-accelerated electron beams over femtosecond timescales in a single fractionation, resulting in unprecedented average dose-rates exceeding 1013 Gy/s. The student will join an interdisciplinary collaboration working at the forefront of radiobiology, at unprecedented durations (femtoseconds) and dose-rates (>1013 Gy/s). The student will design and carry out interdisciplinary experiments using laser-accelerated electron beams at the facilities provided by INO, QUB, and at the Central Laser Facility (CLF) in the UK. The collection of extensive experimental datasets of this kind will be pivotal in advancing our understanding of the micro-physics involved in radiobiological response, will enable benchmarking and improving Monte-Carlo radiation codes such as Geant4-DNA and TOPAS-nBio, and will provide the necessary platform to progress to future pre-clinical studies, including in-vivo irradiation.

Useful references
[1] G. E. Adams, Rad. En. Bio. 17, 95 (1980)
[2] P. J. Low et al, Nat. Comm. 13, 7300 (2022)
[3] T. Freeman Phys. World online resource: https://physicsworld.com/a/radiotherapy-innovation-optimize-the-physics-but-dont-ignore-the-biology/ (2021)
[4] K. Poder et al., Phys. Rev. Lett. 132, 195001 (2024)
[5] C. McAnespie et al., Arxiv:2409.01717 (2024)
[6] C. McAnespie et al., Int. J. Radiat. Oncol. Biol. Phys. 118, 1105 (2024)
[7] C. McAnespie et al., Phys. Rev. E 110, 035204 (2024)

Supervisor(s): Prof. Gianluca Sarri (primary), Prof. Kevin Prise (secondary)

To be eligible for consideration for a Home DfE (covering tuition fees and maintenance stipend of approx. £19,237 per annum), a candidate must satisfy all the eligibility criteria based on nationality, residency and academic qualifications.

To be classed as a Home student, candidates must meet the following criteria and the associated residency requirements:

• Be a UK National,
or • Have settled status,
or • Have pre-settled status,
or • Have indefinite leave to remain or enter the UK.
Email contact: g.sarri@qub.ac.uk

Funding Information

Successful studentships in the Centre for Light Matter Interaction will be allocated on a competitive basis and are subject to confirmation of legal requirements from funding agencies.

Project Summary
Supervisor

Professor Gianluca Sarri

Research Profile


Mode of Study

Full-time: 3 years


Funding Body
CAST Studentship
Apply now Register your interest

Physics overview

The scientific research within the School of Mathematics and Physics was highly rated in the 2021 REF peer-review exercise, with 90% of research being judged as internationally excellent or world-leading. Physics and Astronomy at Queen's has been ranked 14th in the UK (Complete University Guide 2025) and 9th in the UK for Graduate Prospects (Complete University Guide 2024).

Physics research activity in the School is focused into three specific Research Centres; all members of academic staff belong to one of these Research Centres, listed below.

Astrophysics Research Centre (PhD/MPhil)
Find out more below, or email Professor Mihalis Mathioudakis (m.mathioudakis@qub.ac.uk)

Centre for Light-Matter Interactions (PhD/MPhil)
Find out more below, or email Professor Brendan Dromey (b.dromey@qub.ac.uk) or Professor Hugo Van Der Hart (h.vanderhart@qub.ac.uk)

Centre for Quantum Materials and Technologies (PhD/MPhil)
Find out more below, or email Dr Amit Kumar (a.kumar@qub.ac.uk)

Registration is on a full-time or part-time basis, under the direction of a supervisory team appointed by the University. You will be expected to submit your thesis at the end of three years of full-time registration for PhD, or two years for MPhil (or part-time equivalent).

Physics Highlights
Career Development
  • Queen's graduates from Physics have secured employment through a number of companies such as Allstate, AquaQ Analytics, Citigroup, Deloitte, First Derivatives, PwC, Randox, Seagate, Teach First and UCAS. In addition, Belfast has been ranked as the world’s most business friendly small-medium sized city (Financial Times’ fDi Intelligence, 2018)
World Class Facilities
  • Since 2014, the School has invested over £12 million in new world-class student and staff facilities. Maths and Physics students have their own teaching centre that opened in 2016, housing brand experimental physics laboratories, two large computer rooms plus a student interaction area with a new lecture theatre and study rooms. In addition to this, Belfast has one of the lowest student cost of living in the UK (Mercer Cost of Living City Ranking 2023).
Internationally Renowned Experts
  • Physics and Astronomy has been ranked joint 9th in the UK for Graduate Prospects (Guardian University Guide 2025). The School has a continually growing international community of both undergraduate and postgraduate students and staff. Our research is conducted and recognised as excellent across the world. Staff are involved in cutting-edge research projects that span a multitude of fields.
Key Facts

  • Students will have access to our facilities, resources and our dedicated staff. The School of Maths & Physics is one of the largest Schools in the University. Staff are involved in cutting-edge research that spans a multitude of fields.

Course content

Research Information

Research Themes
Astrophysics (PhD/MPhil)

You’ll be involved in the search for distant supernovae and where they came from; study the asteroid and comet population in the Solar system; look for planets orbiting other stars in our Galaxy; study flares and other dynamic processes in the atmosphere of the Sun. You’ll have the opportunity to spend extensive periods at world-leading research centres such as the European Southern Observatory and NASA Goddard Space Flight Center.

At Queen’s we lead major European consortia and are supported by a multi-million pounds portfolio of research grants from a range of sources, including the UK Science and Technology Facilities Council, the Royal Society, and European Union.

Research Themes
Centre for Quantum Materials and Technologies (PhD/MPhil)

Human history is defined by the materials we use to underpin our technology: stone, bronze, iron, silicon. As we enter the emerging Quantum era, this impetus on materials and their link to technologies becomes even stronger. As a PhD student in Centre for Quantum Materials Technologies, you will be playing a part in the development of materials systems which will, in some way, define our technology for the future. How can this not be exciting? You will seek to reveal the physics of material behaviour at the boundary of current global knowledge and quantum limits, at the same time, become proficient in techniques for Quantum computation, materials growth, patterning, characterisation and theoretical modelling.

These skills are highly valued in high-tech companies and commercial research institutions, as well as in academic research settings. Our laboratories and computational facilities are extremely well-equipped for international-level research and our links to other research teams throughout the world in both academia and industry are strong and you should expect to travel, should you wish to, as part of your PhD experience.

Research Themes
Centre for Light Matter Interactions (PhD/MPhil)

Your research will involve identifying, and responding to, major open problems in laser- and electrically-produced plasmas, ultra-fast atomic and molecular physics, the interaction of ionising radiation and plasmas with matter (including biological systems), the physics of antimatter interactions with atoms and molecules, and the description of strong field laser interactions with atoms and molecules.

You will address fundamental and/or practical questions related to the description of electronic excitations, optical properties of matter, and the interaction between electric currents, heat and light. Your theoretical activity will imply the development and programming of novel simulation methodologies to model such processes. Experimentally, you will employ local, national and international facilities, including some of the most powerful laser systems worldwide ,while benefiting from transferring your research findings into the industrial and medical sectors.

Postgraduate research programmes within CQMT provide experience and training in state-of-the art academic research: many of our research strands are world-leading, as evidenced by performance in REF2021. In addition, most of our postgraduate researchers are exposed to functional materials and photonics in major multinational companies.

Prof Marty Gregg - School of Mathematics and Physics
Career Prospects

Alumni Success
Many of our PhD graduates have moved into academic and research roles in Higher Education while others have progressed into jobs such as Data Scientist, Software Engineer, Financial Software Developer, IT Graduate Associate, Technology Consultant, Research Physicist, Telescope Operator and R&D Engineer.
http://www.qub.ac.uk/directorates/sgc/careers/CareersInformationbySchoolandSector/MathsandPhysics/MathsandPhysicsCareerOptions/

People teaching you

Dr Amit Kumar
Head of Research Centre - Centre for Quantum Materials and Technologies
School of Maths and Physics

Prof Brendan Dromey
Co-Head of Research Centre - Centre for Light-Matter Interactions
School of Maths and Physics

Prof Hugo Van Der Hart
Co-Head of Research Centre - Centre for Light-Matter Interactions
School of Maths and Physics

Prof Mihalis Mathioudakis
Head of Research Centre - Astrophysics Research Centre
School of Maths and Physics

Course structure
There is no specific course content as such. A PhD programme runs for 3-4 years full-time or 6-8 years part-time. Students can register for a writing up year should it be required.

The PhD is open to both full and part time candidates and is often a useful preparation for a career within academia or consultancy.

Application Process
Please review the eligibility criteria on the webpages. If you believe that you meet these criteria then follow the steps below:

Select ONE potential supervisor from our list of Academic Staff: https://www.qub.ac.uk/courses/postgraduate-research/find-a-phd-supervisor/ and send an email to that supervisor advising that you are interested in studying for a PhD, stating when you would start, and how you would plan to fund the research. It would be helpful to provide a a brief statement of the research question or interest, and how you think the question could be investigated. The potential supervisor may invite you to meet with them or they may invite you to apply formally.
Assessment

Assessment processes for the Research Degree differ from taught degrees. Students will be expected to present drafts of their work at regular intervals to their supervisor who will provide written and oral feedback; a formal assessment process takes place annually.

This Annual Progress Review requires students to present their work in writing and orally to a panel of academics from within the School. Successful completion of this process will allow students to register for the next academic year.

The final assessment of the doctoral degree is both oral and written. Students will submit their thesis to an internal and external examining team who will review the written thesis before inviting the student to orally defend their work at a Viva Voce.

Feedback

Supervisors will offer feedback on draft work at regular intervals throughout the period of registration on the degree.

Facilities

Our world-class facilities support research and teaching across a diverse range of areas designed to fulfil specific activities. The School contains 4,700m2 of purpose-built laboratory space which includes the ANSIN materials research hub, the Ewald Microscopy Facility (EMF) and the Taranis laser facility. The Teaching Centre (opened in 2016) includes experimental physics laboratories, two large computer rooms and plenty of student study and interaction space. Our laboratories and equipment are looked after by a dedicated team of technicians and are used by our researchers, students and industry.

Entrance requirements

Graduate
The minimum academic requirement for admission to a research programme is normally an Upper Second Class Honours degree from a UK or ROI HE provider, or an equivalent qualification acceptable to the University. Further information can be obtained by contacting the School of Mathematics and Physics.

International Students

For information on international qualification equivalents, please check the specific information for your country.

English Language Requirements

Evidence of an IELTS* score of 6.0, with not less than 5.5 in any component, or an equivalent qualification acceptable to the University is required. *Taken within the last two years

International students wishing to apply to Queen's University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes.

For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs.

If you need to improve your English language skills before you enter this degree programme, INTO Queen's University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this degree.

Tuition Fees

Northern Ireland (NI) 1 TBC
Republic of Ireland (ROI) 2 TBC
England, Scotland or Wales (GB) 1 TBC
EU Other 3 £25,600
International £25,600

1 EU citizens in the EU Settlement Scheme, with settled or pre-settled status, are expected to be charged the NI or GB tuition fee based on where they are ordinarily resident, however this is provisional and subject to the publication of the Northern Ireland Assembly Student Fees Regulations. Students who are ROI nationals resident in GB are expected to be charged the GB fee, however this is provisional and subject to the publication of the Northern Ireland Assembly student fees Regulations.

2 It is expected that EU students who are ROI nationals resident in ROI will be eligible for NI tuition fees. The tuition fee set out above is provisional and subject to the publication of the Northern Ireland Assembly student fees Regulations.

3 EU Other students (excludes Republic of Ireland nationals living in GB, NI or ROI) are charged tuition fees in line with international fees.

All tuition fees quoted are for the academic year 2021-22, and relate to a single year of study unless stated otherwise. Tuition fees will be subject to an annual inflationary increase, unless explicitly stated otherwise.

More information on postgraduate tuition fees.

Physics costs

Depending on the area of research chosen there may be extra costs which are not covered by tuition fees.

Additional course costs

All Students

Depending on the programme of study, there may also be other extra costs which are not covered by tuition fees, which students will need to consider when planning their studies . Students can borrow books and access online learning resources from any Queen's library. If students wish to purchase recommended texts, rather than borrow them from the University Library, prices per text can range from £30 to £100. Students should also budget between £30 to £100 per year for photocopying, memory sticks and printing charges. Students may wish to consider purchasing an electronic device; costs will vary depending on the specification of the model chosen. There are also additional charges for graduation ceremonies, and library fines. In undertaking a research project students may incur costs associated with transport and/or materials, and there will also be additional costs for printing and binding the thesis. There may also be individually tailored research project expenses and students should consult directly with the School for further information.

Bench fees

Some research programmes incur an additional annual charge on top of the tuition fees, often referred to as a bench fee. Bench fees are charged when a programme (or a specific project) incurs extra costs such as those involved with specialist laboratory or field work. If you are required to pay bench fees they will be detailed on your offer letter. If you have any questions about Bench Fees these should be raised with your School at the application stage. Please note that, if you are being funded you will need to ensure your sponsor is aware of and has agreed to fund these additional costs before accepting your place.

How do I fund my study?

1.PhD Opportunities

Find PhD opportunities and funded studentships by subject area.

2.Funded Doctoral Training Programmes

We offer numerous opportunities for funded doctoral study in a world-class research environment. Our centres and partnerships, aim to seek out and nurture outstanding postgraduate research students, and provide targeted training and skills development.

3.PhD loans

The Government offers doctoral loans of up to £26,445 for PhDs and equivalent postgraduate research programmes for English- or Welsh-resident UK and EU students.

4.International Scholarships

Information on Postgraduate Research scholarships for international students.

Funding and Scholarships

The Funding & Scholarship Finder helps prospective and current students find funding to help cover costs towards a whole range of study related expenses.

How to Apply

Apply using our online Postgraduate Applications Portal and follow the step-by-step instructions on how to apply.

Find a supervisor

If you're interested in a particular project, we suggest you contact the relevant academic before you apply, to introduce yourself and ask questions.

To find a potential supervisor aligned with your area of interest, or if you are unsure of who to contact, look through the staff profiles linked here.

You might be asked to provide a short outline of your proposal to help us identify potential supervisors.

Download Postgraduate Prospectus