TRACT will carry out discovery research into biomarkers associated with OOC to develop state-of-the-art diagnostic assays for 1) earlier, more reliable detection, and 2) therapeutic response prediction. Overall, research carried out under WP1 will improve OOC survival rates by developing biomarker-based assays for earlier, more reliable disease diagnosis and stratification of individual patients to more effective chemotherapeutic regimes. This comprehensive patient profiling provides essential information to the clinician, enabling earlier and more accurate diagnosis and the potential to administer more appropriate treatment. This approach will not only benefit the patient, with the potential for improved quality of life, disease control and minimise side-effects by administering more targeted treatment, but will also potentially lead to reduced costs for healthcare providers.
In WP2, TRACT will uncover the molecular basis of drug resistance mechanisms in OOC with the aim of 1) improving the efficacy of existing therapies, 2) identifying new drug targets, and 3) developing novel therapies. Initial pre-clinical testing will be carried out to support future translation to clinical studies.
Current treatment strategies for OOC include a combination of surgery, radiotherapy and chemotherapy. Chemotherapeutic treatment is currently impeded by drug resistance and a lack of selectivity. A greater understanding of the cellular mechanisms that contribute to chemotherapeutic resistance in OOC will enable the development of combination therapies with greater efficacy than current chemotherapeutic regimes. Targeted combination therapies hold the promise of improved response rates, decreased chemotherapeutic toxicity and enhanced survival rates.
In WP3 TRACT will examine metabolic transformation mechanisms in OOC with the aim of identifying new drug targets for future therapeutic development. Metabolic transformation is a universal property of tumour formation and is a rich source of targets for development of therapeutic interventions.
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