Extracellular vesicle-mediated regulation of B cell responses in autoimmune diabetic model
Investigating the potential of extracellular vesicles to modulate cellular responses in autoimmunity. This is a 4-year funded PhD studentship, in collaboration with GSK. The student will have an opportunity for a 3 month secondment to GSK laboratories.
Autoimmune diseases, including rheumatoid arthritis, type I diabetes and systemic lupus, affect up to 10% of the population with debilitating symptoms and a significant economic burden. There is an established role for immune cells called B cells in the development and progression of several autoimmune diseases, and B cell depletion therapies have produced promising results. For non-responding patients a potential therapeutic option is modulating B cell function, particularly of a subset of cells known as regulatory B cells. This project will examine the impact of extracellular vesicles, isolated from inflamed or resting conditions, on distinct B cell populations and disease progression in a murine model of type I diabetes.
The project involves in vivo models, high-parameter flow cytometry, proteomics, and gene expression analysis. It would be suited to an ambitious individual interested in immunology and autoimmunity.
Industrial Cooperative Awards in Science & Technology (CASE) . To be considered eligible you must have been ordinarily resident in the UK for the full 3 year period prior to the start of the studentship and you must be ordinarily resident in Northern Ireland on the first day of the start of the studentship.
Dr Dessi Malinova
Full-time: 3 years