Publications

Publications:

2020

Michael Bingham, Andrew Mills. photonic efficiency and selectivity study of M (M=Pt, Au and Ag)/TiO2 photocatalysts for methanol reforming in the gas phase. Journal of Photochemistry and Photobiology A: Chemistry, vol 389, 15 February 2020, 112257 . https://doi.org/10.1016/j.photochem.2019.112257

2019

Rachel Caines, Amy Cochrane, Sophia Kelaini, Marta Vila-Gonzalez, Chunbo Yang, Magdalini Eleftheriadou, Arya Moez, Alan W. Stitt, Lingfang Zeng, David J. Grieve, Andriana Margariti. The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy. Journal of Cell Science. 2019.132: jcs230276. doi: 10.1242/jcs.230276

Permana AD, McCrudden MTC, Donnelly RF. Enhanced Intradermal Delivery of Nanosuspensions of Antifilariasis Drugs Using Dissolving Microneedles: A Proof of Concept Study. Pharmaceutics. 2019 Jul 17;11(7):346. doi: 10.3390/pharmaceutics11070346. PMID: 31319602; PMCID: PMC6680801.

Cwiklinski K, Donnelly S, Drysdale O, Jewhurst H, Smith D, De Marco Verissimo C, Pritsch IC, O'Neill S, Dalton JP, Robinson MW. The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola. Adv Parasitol. 2019; 10:113-164. doi: 10.1016/bs.apar.2019.01.001. Epub 2019 Feb 26.

Donna M. Small, Ryan R. Brown, Declan F. Doherty, Anthony Abladey, Zhe Zhou-Suckow,Rebecca J. Delaney, Lauren Kerrigan, CaoifaM. Dougan, Keren S. Borensztajn, Leslie Holsinger, Robert Booth, Christopher J. Scott, Guillermo López-Campos, J. Stuart Elborn, Marcus A. Mall, Sinéad Weldon, Clifford C. Taggart. Targeting of cathepsin S reduces cystic fibrosis-like lung disease. European Respiratory Journal 2019. 53: 1801523; DOI: 10.1183/13993003.01523-2018

Wang L, Pavlou S, Du X, Bhuckory M, Xu H, Chen M. Glucose transporter 1 critically controls microglial activation through facilitating glycolysis. Mol Neurodegener. 2019;14(1):2. Published 2019 Jan 11. doi:10.1186/s13024-019-0305-9

Sadaf Ashraf, Samuel Bell, Caitriona O'Leary, Paul Canning, Ileana Micu, Jose A. Fernandez, Michael O'Hare, Peter Barabas, Hannah McCauley, Derek P. Brazil, Alan W. Stitt, J. Graham McGeown, Tim M. Curtis. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation. JCI Insight. 2019; 4(6):e12244 . doi.org/10.1172/jci.insight.122442.

Caitriona O’Leary, Mary K. McGahon, Sadaf Ashraf, Jennifer McNaughten, Thomas Friedel, Patrizia Cincol`a, Peter Barabas, Jose A. Fernandez, Alan W. Stitt, J. Graham McGeown, and Tim M. Curtis. Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis. Invest Ophthalmol Vis Sci. 2019;60:3297–3309. https://doi.org/10.1167/iovs.18-26344.

Carroll LS, Uehara H, Fang D, Choi S, Zhang X, Singh M, Sandhu Z, Cummins PM, Curtis TM, Stitt AW, Archer BJ, Ambati BK. Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina. Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2494-2502. doi: 10.1167/iovs.18-26182. PMID: 31185088; PMCID: PMC6559753.

Pavlou S, Augustine J, Cunning R, Harkin K, Stitt AW, Xu H, Chen M. Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7. Int J Mol Sci. 2019 Apr 29;20(9):2101. doi: 10.3390/ijms20092101. PMID: 31035433; PMCID: PMC6540042.

Olivia E.O'Leary, Paul Canning, Emma Reid, Pietro M.Bertelli, Stuart McKeown ,Michael Brines ,Anthony Cerami, Xuan Du ,Heping Xu , Mei Chen , Louise Dutton , Derek P.Brazil. Reinhold J.Medina , Alan W.Stitt . The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic. Experimental Eye Research.Volume 182, May 2019, Pages 144-155

de la Torre-Escudero E, Gerlach JQ, Bennett APS, et al. Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells. PLoS Negl Trop Dis. 2019;13(1):e0007087. Published 2019 Jan 18. doi:10.1371/journal.pntd.0007087

Vilà-González M, Kelaini S, Magee C, Caines R, Campbell D, Eleftheriadou M, Cochrane A, Drehmer D, Tsifaki M, O'Neill K, Pedrini E, Yang C, Medina R, McDonald D, Simpson D, Zampetaki A, Zeng L, Grieve D, Lois N, Stitt AW, Margariti A. Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling. Stem Cells. 2019 Feb;37(2):226-239. doi: 10.1002/stem.2936. Epub 2018 Nov 17. PMID: 30372556; PMCID: PMC6392130.

Krystyna Cwiklinski, Sheila Donnelly’ , Orla Drysdale, Heather Jewhurst, David Smith, Carolina De Marco Verissimo, Izanara C.Pritsch , Sandra O'Neill , John P.Dalton, Mark W.Robinson. Chapter Three - The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola. Advances in Parasitology , Volume 104, 2019, Pages 113-164. doi.org/10.1016/bs.apar.2019.01.001

Fergie N, Todd N, McClements L, McAuley D, O'Kane C, Krasnodembskaya A. Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair. FASEB J. 2019 Apr;33(4):5585-5598. doi: 10.1096/fj.201802056R. Epub 2019 Jan 16. PMID: 30649987; PMCID: PMC6436662.

Cole G, Ali AA, McErlean E, Mulholland EJ, Short A, McCrudden CM, McCaffrey J, Robson T, Kett VL, Coulter JA, Dunne NJ, Donnelly RF, McCarthy HO . DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen. Acta Biomater. 2019 Sep 15;96:480-490. doi: 10.1016/j.actbio.2019.07.003.

Gonzalez-Fernandez T, Rathan S, Hobbs C, Pitacco P, Freeman FE, Cunniffe GM, Dunne NJ, McCarthy HO, Nicolosi V, O'Brien FJ, Kelly DJ. Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues. J Control Release. 2019 May 10;301:13-27. doi: 10.1016/j.jconrel.2019.03.006. Epub 2019 Mar 8.

Sathy BN, Daly A, Gonzalez-Fernandez T, Olvera D, Cunniffe G, McCarthy HO, Dunne N, Jeon O, Alsberg E, Donahue TLH, Kelly DJ. Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells. Acta Biomater. 2019 Apr 1;88:314-324. doi: 10.1016/j.actbio.2019.02.042. Epub 2019 Feb 27.

Calvin C.L.Cheung Wafa T.Al-Jamal. Sterically stabilized liposomes production using staggered herringbone micromixer: Effect of lipid composition and PEG-lipid content. International Journal of Pharmaceutics. Volume 566, 20 July 2019, Pages 687-696.

Sara G. T. Pereira, Samo Hudoklin, Mateja Erdani Kreft, Nina Kostevsek, Marc C. A. Stuart, Wafa T. Al-Jamal. Intracellular Activation of a Prostate Specific Antigen-Cleavable Doxorubicin Prodrug: A Key Feature Toward Prodrug-Nanomedicine Design Mol. Pharmaceutics2019: 1641573-1585

Sun, D, Tang, M, Zhang, L, Falzon, B, Padmanaban, DB, Mariotti , D, Maguire , P, Xu, H. Chen, M & Sun,D 2019, Microplasma assisted synthesis of gold nanoparticle/ graphene ‘ oxide nanocomposites and their potential application in SERS sensing', Nanotechnology. https://doi.org/10.1088/1361-6528/ab2a23

Chen, Mei ; Obasanmi, Gideon ; Armstrong, David ; Lavery, Nuala-Jane ; Kissenpfennig, Adrien ; Lois, Noemi ; Xu, Heping. / STAT3 activation in circulating myeloid-derived cells contributes to retinal microvascular dysfunction in diabetes. In: Journal of neuroinflammation. 2019 ; Vol. 16, No. 1. pp. 138.

Lechner, Judith ; Hombrebueno, Jose R. ; Pedrini, Edoardo ; Chen, Mei ; Xu, Heping. Sustained intraocular vascular endothelial growth factor neutralisation does not affect retinal and choroidal vasculature in Ins2 Akita diabetic mice. In: Diabetes and Vascular Disease Research. 2019.

Wang, Luxi ; Pavlou, Sofia ; Du, Xuan ; Bhuckory, Mohajeet ; Xu, Heping ; Chen, Mei.Glucose transporter 1 critically controls microglial activation through facilitating glycolysis. In: Molecular Neurodegeneration. 2019 ; Vol. 14, https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-019-0305-9

2018

McCann AP, Smyth P, Cogo F, et al. USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells. Cell Commun Signal. 2018;16(1):77. Published 2018 Nov 8. doi:10.1186/s12964-018-0291-5

Lai Jiang, Michelle K. Greene, Jose Luis Insua, Joana Sa Pessoa, Donna M. Small, Peter Smyth, Aidan P. McCann, Francesco Cogo, J. A. Bengoechea, C. C. Taggart, C. J. Scott. Clearance of intracellular Klebsiella pneumonia infection using gentamicin-loaded nanoparticles. Journal of Controlled Release.279(2018) 316–325. doi.org/10.1016/j.jconrel.2018.04.040

Forsythe N, Refaat A, Javadi A, et al. The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer.Mol Cancer Ther.2 018; 17(6):1280-1290.

Groves HE, Guo-Parke H, Broadbent L, Shields MD, Power UF. Characterisation of morphological differences in well-differentiated nasal epithelial cell cultures from preterm and term infants at birth and one-year. PLoS One. 2018;13(12):e0201328. Published 2018 Dec 5. doi:10.1371/journal.pone.0201328

Dittmer M, Young A, O'Hagan T, Eleftheriadis G, Bankhead P, Dombrowski Y, Medina RJ, Fitzgerald DC. Characterization of a murine mixed neuron-glia model and cellular responses to regulatory T cell-derived factors. Mol Brain. 2018 May 2;11(1):25. doi: 10.1186/s13041-018-0367-6. PMID: 29720228; PMCID: PMC5932845.

Kelaini S, Vilà-González M, Caines R, Campbell D, Eleftheriadou M, Tsifaki M, Magee C, Cochrane A, O'neill K, Yang C, Stitt AW, Zeng L, Grieve DJ, Margariti A. Follistatin-Like 3 Enhances the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Facilitating β-Catenin Nuclear Translocation Through Inhibition of Glycogen Synthase Kinase-3β Activity. Stem Cells. 2018 Jul;36(7):1033-1044. doi: 10.1002/stem.2820. Epub 2018 Apr 10. PMID: 29569797; PMCID: PMC6099345.

Dakir EH, Pickard A, Srivastava K, McCrudden CM, Gross SR, Lloyd S, Zhang SD, Margariti A, Morgan R, Rudland PS, El-Tanani M. The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer. Oncotarget. 2018 Oct 9;9(79):34889-34910.doi:10.18632/oncotarget.26175.PMID:30405882;PMCID:PMC6201850.

Cwiklinski K, Jewhurst H, McVeigh P, et al. Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host. Mol Cell Proteomics. 2018;17(4):792–809. doi:10.1074/mcp.RA117.000445

McCann AP, Smyth P, Cogo F, McDaid WJ, Jiang L, Lin J, Evergren E, Burden RE, Van Schaeybroeck S, Scott CJ, Burrows JF. USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells. Cell Commun Signal. 2018 Nov8;16(1):77.doi:10.1186/s12964-018-0291-5.PMID:30409180;PMCID:PMC6225634

Lai Jiang, Michelle K.Greene ,Jose LuisInsua, Joana SaPessoa, Donna M.Small, Peter Smyth , Aidan P.McCann , Francesco Cogo, Jose A.Bengoechea ,Clifford C.Taggart, Christopher J.Scott. Clearance of intracellular Klebsiella pneumoniae infection using gentamicin-loaded nanoparticles. Journal of Controlled Release. Volume 279, 10 June 2018, Pages 316-325

Hombrebueno, Jose R ; Ali, Imran H A ; Ma, Jian-Xing ; Chen, Mei ; Xu, Heping. Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes. In: Diabetologia. 2018 ; Vol. 61, No. 11. pp. 2433-2446.

McDowell RE, Barabas P, Augustine J, Chevallier O, McCarron P, Chen M, McGeown JG, Curtis TM. Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine. Diabetologia. 2018 Dec;61(12):2654-2667. doi: 10.1007/s00125-018-4707-y. Epub 2018 Aug 15. PMID: 30112688; PMCID: PMC6223850.

McCann AP, Smyth P, Cogo F, McDaid WJ, Jiang L, Lin J, Evergren E, Burden RE, Van Schaeybroeck S, Scott CJ, Burrows JF. USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells. Cell Commun Signal. 2018 Nov 8;16(1):77. doi: 10.1186/s12964-018-0291-5. PMID: 30409180; PMCID: PMC6225634.

Forsythe N, Refaat A, Javadi A, Khawaja H, Weir JA, Emam H, Allen WL, Burkamp F, Popovici V, Jithesh PV, Isella C, Labonte MJ, Mills IG, Johnston PG, Van Schaeybroeck S. The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer. Mol Cancer Ther. 2018 Jun;17(6):1280-1290. doi: 10.1158/1535-7163.MCT-17-0603.Epub2018Feb26.PMID:29483217;PMCID:PMC5985931.

Deevi RK, Javadi A, McClements J, Vohhodina J, Savage K, Loughrey MB, Evergren E, Campbell FC. Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring. J Pathol. 2018 Apr;244(4):445-459. doi: 10.1002/path.5035. Epub 2018 Mar 9. PMID: 29520890; PMCID: PMC5873423.

McVeigh P, McCusker P, Robb E, Wells D, Gardiner E, Mousley A, Marks NJ, Maule AG. Reasons to Be Nervous about Flukicide Discovery. Trends Parasitol. 2018 Mar;34(3):184-196. doi: 10.1016/j.pt.2017.11.010. Epub 2017 Dec 18.

Mills, Andrew; Bingham, Michael; O'Rourke, Christopher; Bowker, Michael. Modelled kinetics of the rate of hydrogen evolution as a function of metal catalyst loading in the photocatalysed reforming of methanol by Pt (or Pd)/TiO2. Journal of Photochemistry and Photobiology A: Chemistry, 31.12.2018.

2017

Evergren E, Cobbe N, McMahon HT. Eps15R and clathrin regulate EphB2-mediated cell repulsion. Traffic. 2018 Jan;19(1):44-57. doi: 10.1111/tra.12531. Epub 2017 Nov 6. PMID: 28972287; PMCID: PMC5836524.

Greene MK, Richards DA, Nogueira JCF, et al. Forming next-generation antibody-nanoparticle conjugates through the oriented installation of non-engineered antibody fragments. Chem Sci. 2017;9(1):79-87. Published 2017 Aug 14. doi:10.1039/c7sc02747h

Morrison TJ, Jackson MV, Cunningham EK, Kissenpfennig A, McAuley DF, O'Kane CM, Krasnodembskaya AD. Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer. Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286. doi: 10.1164/rccm.201701-0170OC. PMID: 28598224; PMCID: PMC5694830.

Greene MK, Richards DA, Nogueira JCF, Campbell K, Smyth P, Fernández M, Scott CJ, Chudasama V. Forming next-generation antibody-nanoparticle conjugates through the oriented installation of non-engineered antibody fragments. Chem Sci. 2017 Aug 14;9(1):79-87. doi: 10.1039/c7sc02747h. PMID: 29629076; PMCID: PMC5869316. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869316/

R. Clarke, K. Monaghan, Imad About, CS. Griffin, G. P. Sergeant, Ikhlas El Karim, J. G McGeown, S. L. Cosby, T. M. Curtis, L. P. McGarvey, Fionnuala T. Lundy. TRPA1 activation in a human sensory neuronal model: relevance to cough hypersensitivity? European Respiratory Journal 2017 50: 1700995; DOI: 10.1183/13993003.00995-2017

Lacoma A, Cano V, Moranta D, Regueiro V, Domínguez-Villanueva D, Laabei M, González-Nicolau M, Ausina V, Prat C, Bengoechea JA. Investigating intracellular persistence of Staphylococcus aureus within a murine alveolar macrophage cell line. Virulence. 2017 Nov 17;8(8):1761-1775. doi: 10.1080/21505594.2017.1361089. Epub 2017 Sep 12. PMID: 28762868; PMCID: PMC5810471.

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