Modules

• Year 1

  Core Modules

  Molecular Basis of Life (40 credits)

  ×

  Molecular Basis of Life

  Overview

  Molecular Basis of Life is a Stage 1 40 CAT module that runs throughout the academic year (semester 1 and semester 2). The module provides a comprehensive introduction to the molecular basis of life from the molecular level through to cells, tissues and whole organisms. This module broadly covers biochemistry, molecular biology and genetics in the context of life of earth. The course begins with an introduction to the chemical context of life (elements, compounds, molecules, atoms, bonding and thermodynamics) and biomolecules (amino acids, proteins, nucleic acids, carbohydrates, lipids), to include the molecular and biochemical processes which underpin life on earth (DNA replication, RNA transcription and translation, genetic code and mutation, protein biochemistry, enzyme kinetics, glucose metabolism, metabolism control, and photosynthesis). Students are introduced to basic cell structure and communication to facilitate exploration of life at all levels and in different environmental conditions, and allow understanding of the evolutionary scales of biological systems. Students receive teaching on classical genetics (chromosome structure, cytogenetics, diploid inheritance, allelic and epistatic interactions, aneuploidy, polyploidy, cytoplasmic inheritance) and population genetics to understand of the importance of natural selection and evolutionary processes. This will be followed by the introduction of ‘omics technologies including bioinformatics, and practical methods in molecular and cellular biology including genetic engineering tools and biochemistry techniques. The applications of genetic engineering, biotechnology, and biochemical tools/assays will be explored in the form of case studies.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate knowledge and understanding of the chemistry of life and its application to biological sciences.
  LO2: Discuss the biochemical processes that govern life on earth.
  LO3: Describe and explain the structures, roles and activities of the major biological molecules, sub-cellular components and cell types.
  LO4: Demonstrate a knowledge and understanding of biodiversity and organismal biology.
  LO5: Demonstrate a knowledge and understanding of the molecular basis of genetics (classical, population) and its applications (genetic manipulation and ‘omics’ technologies).
  LO6: Develop problem solving skills and the ability to analyse data.
  LO7: Develop communication skills including report writing and oral presentations
  LO8: Develop an understanding of Good Laboratory Practice (GLP), health and safety in the laboratory and ethical practice.
  LO9: Demonstrate competence in specific laboratory practical and manipulative skills
  LO10: Demonstrate the ability to work as part of a team and reflect on their role in the team.

  Skills

  Development of laboratory skills related to molecular biology, biochemistry and genetics as evidenced through Practical Skills Portfolio; Group project work; Report writing; Critical and logical analysis of data; Peer and self-assessment; Computational analyses of genome/transcriptome data

  Coursework

  40%

  Examination

  60%

  Practical

  0%

  Stage/Level

  1

  Credits

  40

  Module Code

  BIO1304

  Teaching Period

  Full Year

  Duration

  24 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  The World of Microorganisms (40 credits)

  ×

  The World of Microorganisms

  Overview

  The World of Microorganisms (BIO1301): is a full year 40 CAT module that provides a practical and theoretical introduction to the biology of bacteria, viruses, fungi, algae, protozoa and parasites. Students will gain an appreciation that diversity of life on earth is the result of evolution. Microbial cell morphology; structure and function of cell components. Growth, reproduction and enumeration of microorganisms. Aspects of microbial genetics. The effects of physical and chemical environments on microbial growth. The diversity of microorganisms and aspects of their pathogenicity in humans and animals. The role of microorganisms in food and health, their beneficial uses, and some aspects of microbial biotechnology as it relates to these areas.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Describe and explain the basic structure of economically and medically important examples of bacteria, viruses, fungi, together with protozoan and metazoan parasites.
  LO2: Demonstrate an understanding organismal biology including the diversity of life and its evolution.
  LO3: Discuss the various interactions that such organisms may have with animals and plants.
  LO4: Describe and explain how microorganisms relate to production and use of food.
  LO5: Discuss how such organisms may contribute to the manifestation of disease.
  LO6: Demonstrate the biotechnological potential of such organisms for the benefit of humankind.
  LO7: Develop an understanding of Good Laboratory Practice (GLP), health and safety in the laboratory and ethical practice.
  LO8: Develop problem solving skills.
  LO9: Develop communication skills including report writing and essay writing.
  LO10: Demonstrate competence in microbiology specific laboratory practical and manipulative skills.
  LO11: Demonstrate the ability to work as part of a team.

  Skills

  Development of laboratory skills related to microbiology, recording and appropriate analysis and presentation of scientific data. Problem solving. Team working. Effective assimilation of knowledge and written communication skills.

  Coursework

  40%

  Examination

  60%

  Practical

  0%

  Stage/Level

  1

  Credits

  40

  Module Code

  BIO1301

  Teaching Period

  Full Year

  Duration

  24 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Optional Modules

  Ecology and Environmental Science (20 credits)

  ×

  Ecology and Environmental Science

  Overview

  Ecology and Environmental Science (BIO1309) is a 20 CAT module that provides an introduction to the core concepts of ecology and the practical applications of environmental science and conservation. The course material is taught through lectures and an off-site, 3-day residential, field-trip.
  
  
  
  The module begins with a primary overview the interactions between organisms and their environment (abiotic and biotic) by developing the principal concepts of ecology. Lectures begin with a fundamental scientific understanding of ecology - building up in scale from individuals to ecosystems. Initial topics begin with physiological and behavioural responses to the environment and move on to the growth and dynamics of populations. Interspecific interactions are considered next within the context of community ecology. Finally, ecosystem structure, function and services are considered before finishing with landscape and global ecology.
  
  
  
  The module then moves towards more practical and applied ecology through studying environmental problems in terms of their causes, assessment and remediation. Lectures focus on the most severe anthropogenic stressors including climate change, habitat destruction, pests/invasive species, pollution and overharvesting. Students will apply their foundational knowledge to work through case-studies based on common conservation strategies that are used to mitigate and manage topical issues of environmental concern. In the final portion of the course, practical methods in environmental biology are then introduced through a set of interactive "Ecological toolbox" lectures and tutorials. Hands-on experience in the application of practical skills and knowledge is then developed through an intensive off-site field course during the Easter vacation (compulsory for all students). At the end of the module students should have a basic understanding of ecology and be able to apply this understanding to topical issues of environmental concern.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  
  
  LO1: Describe the theories and mechanisms relating to the interactions of organisms with their environment (abiotic and biotic).
  
  LO2: Describe factors determining the organisation of organisms into populations, communities, ecosystems and biomes.
  
  LO3: Develop field work skills including; observation, recording, statistical analysis, experimental design and structure-function interpretation.
  
  LO4: Discuss ecological and environmental issues and how they impact biodiversity
  
  LO5: Develop problem solving ability and the ability to analyse data.
  
  LO6: Demonstrate the ability to work as part of a team.
  
  LO7: Develop communication skills in the form of report and essay writing.

  Skills

  Development of field skills evidenced through Practical Skills Portfolio; Report writing; Critical and logical analysis of ecological data.

  Coursework

  50%

  Examination

  50%

  Practical

  0%

  Stage/Level

  1

  Credits

  20

  Module Code

  BIO1309

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Optional

  Fundamentals of Chemistry (20 credits)

  ×

  Fundamentals of Chemistry

  Overview

  STAFF
  
  NAME CONTRIBUTION
  
  Dr A. C. Marr a.marr@qub.ac.uk
  Module Co-ordinator
  General Chemistry - 18 Lectures; Skills Workshops – part 1, Essential Calculations for Practical Chemistry
  Dr P. C. Marr p.marr@qub.ac.uk
  Skills workshop – Laboratory Skills parts 1 and 2
  Prof. P. Stevenson p.stevenson@qub.ac.uk
  Organic Chemistry: Functional Group Chemistry 15 Lectures, 5 Seminars Organic Chemistry Laboratory
  Dr P. Dingwall p.dingwall@qub.ac.uk
  Organic Chemistry Laboratory
  Dr M. Swadzba-Kwasny Swadzba-kwasny@qub.ac.uk
  Skills workshop – Scientific writing and researching skills.
  
  Course content
  
  General Chemistry - Elements, Atoms, ions, electrons and the periodic table. This course aims to give an introduction to the fundamental principles of atoms from the chemists’ viewpoint. Starting from a simple model and using the results of quantum mechanics a more appropriate model of the atom is presented. From this model trends in atomic and ionic properties which enable us to explain differences and similarities and predict the properties of different elements can be deduced. The following topics are covered:
  * The Basics: Element, The periodic table, atom, mole.
  * The Atom: The Bohr Atom.
  * The Electron: Wave-Particle Duality and The Schrödinger Wave Equation, Probability Density, Radial Distribution Function, Orbitals, Quantum Numbers, s and p Orbitals, Phase, d Orbitals.
  * More than One Electron: Filling orbitals, The aufbau principle, The Pauli Exclusion Principle, Hund’s rules, Penetration, Shielding, Effective Nuclear Charge, Slater’s Rules, Size.
  * Trends: Ionization energy, Electron attachment enthalpy (affinity), Electronegativity, Ionic radii, Polarizability and polarizing power, Hydration enthalpies, Redox potentials. General Chemistry - Structure and Bonding. This course introduces some important theories of bonding. Theories of bonding are discussed in some detail for discrete molecules. The discussion of bonding in molecular species centres on the valence bond and molecular orbital theories. Intermolecular forces between molecules are also discussed.
  * Introduction to bonding: Discussion of types of structure and common bonding theories, examples of representative structures.
  * Homonuclear Diatomic Molecules: Interatomic distance and covalent radii, Potential energy curves, attractive and repulsive forces, bond energy and enthalpy. Lewis structures, filled shells, the octet rule. Wavefunction, introduction to valence bond theory and molecular orbital theory, Valence bond theory: ionic and covalent contributions, resonance; Molecular orbital theory: molecular orbitals, linear combinations of atomic orbitals, orbital overlap, bonding and antibonding orbitals, MO diagrams, some shapes of MO’s, labelling MO’s, examples of simple MO diagrams, bond order.
  * Heteronuclear Diatomic Molecules: Lewis structures, valence bond approach, Molecular orbital theory, energy matching, symmetry, non-bonding orbitals; electronegativity, electric dipole moments, carbon monoxide, isoelectronic molecules.
  * Polyatomic Molecules: Metal complexes and covalent polyatomics, coordination number, common geometries, molecules obeying the octet rule, valence bond theory, expanding the octet, hybridization (sp, sp2, sp3), formal charge, single, double and triple carbon-carbon bonds, molecular shapes; molecular orbital theory: ligand group orbitals; comparison of VB and MO, macromolecules, fullerenes, proteins and hydrogen bonding.
  * Intermolecular Forces: Van-der-Waal forces, strength of forces.
  * Introduction to solids with extended structures: metals and semi-metals, ionic solids and covalent solids. Only covered if time permits. ORGANIC CHEMISTRY: Functional Group Chemistry
  * Draw structural formula to represent organic compounds, identify isomers and convert structural formula to molecular formula.
  * Identify common organic functional groups, name organic compounds containing these groups, and predict their chemistry and reactivity.
  * Recognise nucleophiles, electrophiles and bases and identify which chemistry these species participate in. Appreciate the importance of acidity and basicity in organic chemistry
  * Sketch substitution, elimination and addition mechanisms and appreciate the importance of ‘mechanism’ in rationalising organic chemical reactions. * Suggest reagents for interconverting one functional group into another. * The functional groups which will be used to illuminate these outcomes are alkanes, alcohols, amines, alkyl halides, alkenes, alkynes, carbonyls compounds including aldehydes, ketones, carboxylic acids, esters and amides.
  SKILLS WORKSHOPS:
  * Scientific writing and researching skills
  * Laboratory skills
  * Essential calculations for practical chemistry
  ORGANIC CHEMISTRY LABORATORY:
  * 3 x 3 hours laboratories with associated write-ups.

  Learning Outcomes

  Students will become familiar with chemical descriptions of matter. What matter is made up of, how it can be organised into the periodic table and how we can start to understand it from a scientific perspective. They will learn about organic compounds and how they can be prepared, named and reacted.

  Skills

  Learners are expected to demonstrate the following on completion of the module:
  * Ability to write and predict atomic structure and properties.
  * Ability to explain and understand bonding.
  * Ability to recognise functional groups in organic chemistry and name compounds.
  * Ability to suggest reagents, mechanisms and reactions in organic chemistry.
  * Ability to demonstrate fundamental skills in laboratory practice and associated calculations.

  Coursework

  50%

  Examination

  0%

  Practical

  50%

  Stage/Level

  1

  Credits

  20

  Module Code

  CHM1011

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Optional

  Biodiversity (40 credits)

  ×

  Biodiversity

  Overview

  Biodiversity (BIO1305) is a full year 40 CAT module that provides a fundamental introduction to (i) the diversity in form, function and biology of eukaryotic organisms, (ii) the core concepts of ecology and (iii) the practical applications of environmental science and conservation. The course material is taught through lectures, laboratory practicals, tutorials, and a residential field-trip (3 days, Queen’s Marine Laboratory, Portaferry). This course builds on previous fundamental knowledge and provides an essential foundation for future learning.). A quantitative approach is emphasised throughout the module and practical data analysis methods are taught during tutorial sessions.
  
  The module begins with a primary overview of the evolution of life, the concept of populations and the mechanisms of speciation. A comparative evolutionary approach is taken to present the modern classification of life and the evolutionary relationships between organisms. Using the phylogenic history of life as a structural framework, the course systematically tracks through the evolution of major lineages and their defining functional traits - from simple organisms like prokaryotes all the way through to the vertebrates. Information is given for each group of organisms on classification, evolutionary history, life cycles, morphology and physiology. First the prokaryotes (bacteria and archaea) are explored, then protist groups including algae are next, followed by the evolution of higher plants and finally fungi. Animals then follow and are dealt with on a group by group basis in a sequential fashion, starting with the invertebrates and finishing with the chordates.
  
  After establishing a foundational knowledge about eukaryotic diversity, the module progresses on to discuss the interactions between these organisms and their environment (abiotic and biotic) by developing the principal concepts of ecology. Lectures begin with a fundamental scientific understanding of ecology - building up in scale from individuals to ecosystems. Initial topics begin with physiological and behavioural responses to the environment and move on to the growth and dynamics of populations. Interspecific interactions are considered next within the context of community ecology. Finally, ecosystem structure, function and services are considered before finishing with landscape and global ecology.
  
  The module then moves towards more practical and applied ecology through studying environmental problems in terms of their causes, assessment and remediation. Lectures focus on the most severe anthropogenic stressors including climate change, habitat destruction, pests/invasive species, pollution and overharvesting. Students will apply their foundational knowledge to work through case-studies based on common conservation strategies that are used to mitigate and manage topical issues of environmental concern. In the final portion of the course, practical methods in environmental biology are then introduced through a set of interactive "Ecological toolbox" lectures and tutorials. Hands-on experience in the application of practical skills and knowledge is then developed through an intensive off-site field course during the Easter vacation (compulsory for all students)
  
  At the end of the module students should have a basic understanding of biological diversity and ecology and be able to apply this understanding to topical issues of environmental concern and to more advanced studies in biology.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate a knowledge and understanding of the diversity in form, function and biology of living organisms.
  LO2: Apply skills of observation, recording, statistical analysis, microscopy, dissection, experimental design and structure-function interpretation through practical laboratory and field work.
  LO3: Describe the role of biotic and abiotic factors in determining the distributions and abundance of organisms; their organisation into populations, communities, ecosystems and biomes.
  LO4: Describe the theories and mechanisms relating to the interactions of organisms with their environment.
  LO5: Discuss ecological and environmental issues and how they impact biodiversity.
  LO6: Develop problem solving ability and the ability to analyse data.
  LO7: Demonstrate the ability to work as part of a team.
  LO8: Develop communication skills in the form of report and essay writing.
  LO9: Develop an understanding of health and safety in the laboratory and field and ethical practice.

  Skills

  Observation, recording, analysis, microscopy, dissection, and structure-function interpretation. Recognition of diversity within major groups of living organisms. Practical skills in laboratory and field investigations; use of computers in data analysis, statistical analysis, professional technical report writing and team-work. Experimental design and survey design.

  Coursework

  50%

  Examination

  50%

  Practical

  0%

  Stage/Level

  1

  Credits

  40

  Module Code

  BIO1305

  Teaching Period

  Full Year

  Duration

  24 weeks

  Pre-requisite

  No

  Core/Optional

  Optional

  Structure, Reactivity and Mechanism in Organic and Bioorganic Chemistry (20 credits)

  ×

  Structure, Reactivity and Mechanism in Organic and Bioorganic Chemistry

  Overview

  STAFF
  
  NAME CONTRIBUTION
  Dr. K.Tchabanenko
  k.tchabanenko@qub.ac.uk STRUCTURE AND CHEMISTRY OF FUNCTIONAL GROUPS
  (12 Lectures, 1 Seminar); INFRARED, ULTRAVIOLET AND VISIBLE SPECTROSCOPY (2 Lectures, 1 Seminar)
  Dr. G. Sheldrake
  g.sheldrake@qub.ac.uk AROMATIC CHEMISTRY (8 Lectures, 1 Seminars)
  Dr. N. Gunaratne
  N.Gunaratne@qub.ac.uk STEREOCHEMISTRY (5 Lectures, 1 Seminar)
  Dr. S. Cochraine
  s.cochrane@qub.ac.uk NATURAL PRODUCT CHEMISTRY (4 Lectures, 1 Seminar)
  
  STRUCTURE AND CHEMISTRY OF FUNCTIONAL GROUPS
  
   The concept of the functional group in organic chemistry. Review of the atom-to-atom bonding sequences, electron configuration, hybridization, geometry and electronegativity features of the common functional groups.
  
   The following functional groups will be examined: halides, alcohols, cyanides, ethers, alkenes, alkynes, amines, aldehydes, ketones, acids, acyl halides, amides and esters. The emphasis will be on methods of introduction and interconversion and the important mechanistic links between them, viz. nucleophilic substitution, elimination, addition, reduction, oxidation, hydration and hydrolysis.
  
  AROMATIC CHEMISTRY (8 Lectures, 1 Seminars)
  
   Aromatic Chemistry of Benzene Derivatives
   Bonding in benzene: Concepts of resonance, delocalisation and aromatic stabilisation.
   Nomenclature of substituted aromatics.
   SEar reactions: mechanisms and prominent (name) reactions: nitration, halogenation, acylation, and alkylation.
   Distribution: mechanisms and direction (ortho, meta, para ratios).
   Aromatic amines and diazonium salts: preparation and reactions of.
   Phenols: preparation, acidity and reactions; preparation of aspirin.
   Nucleophilic aromatic substitutions: various mechanisms and preparative applications.
  
   Heterocyclic Chemistry
   Classes: electron-deficient and electron-rich heteroaromatics.
   Five-membered heterocycles: pyrrole, thiophene, furan (structure, properties, electrophilic substitution).
   Six-membered heterocycles: pyridine (structure and substitution chemistry).
  
  
  STEREOCHEMISTRY
  
   Stereochemistry is described in this section of the module at an introductory level. Methods for drawing three-dimensional structures, including Fischer and Newman projections, and the notation used to indicate stereochemistry will be illustrated. Stereochemical descriptors for configuration and geometry (R and S; E and Z), and the sequence rules used for their assignment will be described.
  
   We will define and distinguish the concepts of constitution, configuration, and conformation using clearly illustrated examples. The conformation, or three-dimensional shape of molecules, and the barriers to bond rotation, will be described and illustrated. A special focus will be placed on cyclohexane and the effects of ring substitution on the most stable conformation. We will then discuss different forms of stereoisomerism based on stereogenic tetrahedral carbon atoms, including enantiomers, diastereoisomers, and meso compounds, together with the difference between relative and absolute stereochemistry. Molecular chirality and the role of symmetry will be discussed, together with its occurrence in Nature.
  Racemic mixtures, and resolution will be discussed in the context of optical activity and its measurement using plane polarised light.
  
   Using these concepts we will develop an understanding of the stereochemistry of chemical reactions, which will be illustrated using examples of nucleophilic substitution and addition to carbon-carbon double bonds.
  
  NATURAL PRODUCT CHEMISTRY
  
   Carbohydrates: - classes, nomenclature and stereochemical conventions
  - conformations, equilibria, mutarotation
  - analytics and reactions of.
   Amino Acids: - types and properties (ampoteric character, pl values,
  analysis and detection)
  - chemical reactions, synthesis, amide/peptide formation
  - oligo- and polypeptides: natural occurance and molecular structures.
  
  INFRARED, ULTRAVIOLET AND VISIBLE SPECTROSCOPY
  
  The electromagnetic spectrum. Energy absorption.
  
   IR Spectroscopy –
   Hooke's Law approximation, stretching and bending vibration modes. IR spectrometers.
   Characterisation by IR spectroscopy - group frequencies, finger print region. Specific group frequencies - C-H stretch, (bend), C=C and C=C stretch, O-H stretch, N-H stretch, C=O stretch (and factors affecting it), C=N stretch, o.m.p. bend in mono- and disubstituted benzene derivatives.
   Uses of IR spectroscopy.
  
   UV and Visible Spectroscopy.
   Apparatus for uv/visible spectrometry.
   Lambert-Beer Law.
   Electronic excitation .
   Chromophores. Effect of conjugation. Benzenoid compounds. Empirical rules for predicting wavelength of absorption of dienes and enones.

  Learning Outcomes

  Upon completion of this module, the students will have gained a theoretical and practical understanding of basic Organic Chemistry. They will be able to relate organic chemistry to pharmaceutical and biological subjects.

  Skills

  Knowledge of basic organic chemistry. Practical experimental chemistry skills. Numeracy. Report writing.

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  1

  Credits

  20

  Module Code

  CHM1004

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Optional

• Year 2

  Core Modules

  Microbial Metabolism and Biocatalysis (20 credits)

  ×

  Microbial Metabolism and Biocatalysis

  Overview

  1. Aspects of microbial metabolism, especially pertaining to environmental nutrient cycles.
  2. Introduction to gene mining from microbial metagenomes
  3. Aspects of protein engineering including directed evolution
  4. Application of enzymes and proteins to biotechnology applications, including biocatalysis.

  Learning Outcomes

  1. Understand how some recent concepts in bioprocesses have impact across industrial & environmental applications.
  2. Appreciate the interdisciplinary nature of modern biotechnology, especially the interplay of microbial metabolism and environmental biotechnology.
  3. Be able to translate fundamental science discoveries into technology innovation in the field of biocatalysis.
  4. Demonstrate scientific writing skills.
  5. Analyse gene/protein sequence data in a biocatalysis context using bioinformatics tools (through lab based learning).
  6. Develop critical skills in molecular analysis of microbial proteins and related biochemical pathways that can be applied to solve real world technical problems.

  Coursework

  0%

  Examination

  60%

  Practical

  40%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2311

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Microorganisms in Action (20 credits)

  ×

  Microorganisms in Action

  Overview

  This module will expand on topics introduced at Stage 1 in the BIO1301 The World of Microorganisms module and aims to promote deeper understanding and appreciation of the importance of microorganisms in our world. Practical skills be will enhanced in the module and students will be introduced to a range of biochemical techniques commonly used by microbiologists.
  
  Content will include:
  
  - Examination of a range of biochemical techniques that are commonly used by microbiologists; this includes chromatography and electrophoresis, use of radioisotopes, kinetic and chemical properties of bio-molecular interactions, antibody production and the potential diagnostic, therapeutic and food safety applications of antibodies
  
  - Methods for studying the role and function of microorganisms in the environment and in biofilms (culturomics, phylogenetic studies, genomics, metagenomics, proteomics, sequencing)
  
  - Extremophiles – how microorganisms adapt to different stresses
  
  - Clinical Microbiology - microbial interactions with humans (how pathogens cause disease, automated methods for detecting human pathogens, emerging antibiotic resistant pathogens, gut microbiome, probiotics)
  
  - Functionality of Fungi – medical and scientific importance of fungi
  
  - Water Microbiology – waterborne pathogens, provision of a safe drinking water supply, measuring water quality
  
  - Food Microbiology – important foodborne zoonotic pathogens, phage based detection of foodborne pathogens, bio-preservation of food and probiotics and food fermentations

  Learning Outcomes

  By the end of the module students should:
  1. Be able to demonstrate an understanding of the principles of and have practical experience of a range of biochemical techniques commonly used by microbiologists
  2. Have developed an appreciation of the ubiquity, importance and tenacity of microorganisms in our world.
  3. Be able to understand and describe the key roles and activities of microorganisms involved in plant health, food production and human health
  4. Be able to demonstrate an understanding of the molecular techniques that are used to study microbial populations.

  Skills

  i) Assimilation of information (lectures and practicals)
  ii) Practical laboratory skills (practicals)
  iii) Data presentation and interpretation (practicals and practical reports)
  iv) Written communication (practical reports and class test)

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2202

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Molecular Genetics and Bioinformatics (40 credits)

  ×

  Molecular Genetics and Bioinformatics

  Overview

  This module covers the structure and organisation of prokaryotic and eukaryotic genomes and genes, recombinant DNA technology, gene regulation, epigenetics, genomics, transcriptomics, biological databases and application of these to the study of cancer genetics. This module builds on material covered in Molecular Basis of Life (Level1). Teaching is delivered via lectures and corresponding hands on wet lab and bioinformatics practical work. The course is designed to prepare students for Level 3 courses such as Bacterial Genetics & Genetic Manipulation, and Immunology and Immunotherapy and for the Honours research projects that involve molecular biology and bioinformatics analysis.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate an understanding of the structural features of DNA and RNA and the enzymes involved in genetic information flow
  LO2: Demonstrate an understanding of genome maintenance (DNA duplication mechanisms; DNA mutations, damage and repair)
  LO3: Demonstrate an understanding of the molecular mechanisms involved in gene expression and translation in Prokaryotes and Eukaryotes systems appreciating the differences between the two systems.
  LO4: Evaluate and appreciate the importance of the experimental approach and the practical methodologies employed in molecular biology and bioinformatics platforms
  LO5: Discuss the molecular genetics of cancer, NGS and application of NGS to the study of cancer
  LO6: Develop independent learning, critical thinking and problem solving ability
  LO7: Develop communication skills including report writing.
  LO8: Demonstrate competence in specific bioinformatics and laboratory practical and manipulative skills.

  Skills

  Skills you will learn:
  (see further information in Practical handouts)
  
  •Basic skills in solution preparation, storage, and usage for molecular techniques
  •Agarose gel analysis of DNA
  •PCR
  •Restriction digestion of DNA
  •Purification of DNA
  •Cloning of PCR product into plasmid
  •Bacterial transformation
  •Identification of recombinant bacterial clones
  •Plasmid purification
  •Bioinformatics analysis of the plasmid sequencing data (NCBI, BLAST)
  • Specific bioinformatics skills related to analysis of genome sequencing data
  •Specific bioinformatics skills related to MLST and MLSA analysis
  •Specific bioinformatics skills related to transcriptomics and differential gene expression analysis
  •Safe working within the laboratory environment
  •Recording of data and appropriate analysis
  •Data presentation and interpretation
  •Oral and written communication skills
  •Problem solving
  •Team working
  •Effective assimilation of knowledge and written communication skills

  Coursework

  50%

  Examination

  50%

  Practical

  0%

  Stage/Level

  2

  Credits

  40

  Module Code

  BIO2305

  Teaching Period

  Full Year

  Duration

  24 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Advanced Cell Biology (20 credits)

  ×

  Advanced Cell Biology

  Overview

  This module builds on the fundamental coverage of cell biology that is delivered in pre-requisite module BIO2104 (i.e. cell structure and function from the perspective of individual organelles, and their interactions, and how disease can arise when these break down).
  
  In BIO2304 we focus on cutting edge techniques that can be used to investigate cell function at a variety of levels including:
  Cell culture
  Fluorescence microscopy
  Transmission and scanning electron microscopy
  RNAi / CRISPR
  Proteomics
  Inhibitors and drug development pipelines
  
  We highlight how the use of these tools can provide a better understanding of disease mechanisms and aid the development of new treatment options. Case studies include:
  Cancer cell biology
  Stem cell research
  Neurones and neurotransmitters

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate an understanding of the theoretical basis of classical and emerging technologies that are used to study cells.
  LO2: Appreciate how these tools can provide a deeper understanding of cell function and disease mechanisms.
  LO3: Discuss how advances in technology is driving research into new therapeutic strategies for various diseases.
  LO4: Appreciate the importance of experimental approach and apply practical cell biology methodologies.
  LO5: Demonstrate scientific communication skills including report writing and peer discussion.
  LO6: Demonstrate the ability to work as part of a team and reflect on their role in the team.
  LO7: Appreciate health and safety in the laboratory and ethical practice.
  LO8: Develop independent learning, critical thinking and problem solving ability.

  Skills

  Observation, recording, data analysis, microscopy, image analysis and experimental design. Practical skills in laboratory investigations including use of specialised software in data analysis, professional technical report writing and team-work.
  
  -------------------

  Coursework

  40%

  Examination

  60%

  Practical

  0%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2304

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Cell Biology (20 credits)

  ×

  Cell Biology

  Overview

  Detailed coverage of cell structure and function from the perspective of individual organelles and their interactions including:
  
  The variety of cells
  The cell cycle
  Cell Signalling
  The nucleus & the cytoplasm
  The mitochondrion & energy production
  Ribosomes & protein synthesis
  The secretory pathway
  Exosomes
  Membrane pumps and transporters
  Cytoskeleton
  Blood cells & pathologies
  
  How breakdown of normal organelle function can lead to disease and how a knowledge of cell biology has helped to develop appropriate treatments, e.g.:
  
  Cystic fibrosis
  Cancer
  Lysosomal storage diseases
  Sickle cell anaemia

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Describe the structure and function of the major cell organelles and their interactions with each other
  LO2: Demonstrate knowledge of how a better understanding of cell biology can lead to the development of new therapeutic strategies in various disease states
  LO3: Appreciate the importance of experimental approach and the practical methodologies employed in cell biology
  LO4: Develop independent learning, critical thinking and problem solving ability

  Skills

  Observation, recording, data analysis, microscopy, basic haematology, image analysis and experimental design. Practical skills in laboratory investigations including use of specialised software in data analysis, professional technical report writing and team-work.
  ------------------------

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2104

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

• Year 3

  Core Modules

  Professional Studies (120 credits)

  ×

  Professional Studies

  Overview

  1. Preplacement preparation including; the selection of placement,
  application forms, CV's and interviews. Evaluation of placement by student,
  including potential to relate academic theory to the work place, skills
  development and project development.
  2. On placement work including; relating academic theory to the workplace, recording activities and reflection in a log book. 3. Post placement reflection of learning and career prospects.
  
  
  
  
  1. Preplacement preparation including; the selection of placement,
  application forms, CV's and interviews. Evaluation of placement by student,
  including potential to relate academic theory to the work place, skills
  development and project development.
  2. On placement work including; relating academic theory to the workplace, recording activities and reflection in a log book. 3. Post placement reflection of learning and career prospects.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Apply subject knowledge of theoretical and practical concepts to provide solutions in the work-related environment
  LO2: Evidence development in work related transferable skills
  LO3: Manage and deliver project type work in the workplace setting
  LO4: Demonstrate employability skills and an enhanced career plan.
  LO5: Demonstrate an understanding of the importance of Health and Safety in the work environment.
  LO6: Exhibit effective communication skills in both the academic and work environment.
  LO7: Demonstrate the ability to work as part of a team and reflect on your role in the team.
  LO8: Evaluate and reflect upon your learning experience in the work environment

  Skills

  Students will identify and evaluate the skills which they have developed
  during the placement, which may include: communication (oral and written); problem-solving; team work; IT; presentational; personal development and reflection.

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  3

  Credits

  120

  Module Code

  BIO3303

  Teaching Period

  Full Year

  Duration

  40 weeks

  Pre-requisite

  No

  Core/Optional

  Core

• Year 4

  Core Modules

  Medical Microbiology (20 credits)

  ×

  Medical Microbiology

  Overview

  This module will expand on topics introduced at Stage 1 in the BIO1301 World of Microorganisms module and the Stage 2 Microorganisms in Action module. It will examine key areas of infection and immunity that relate to the pathogenesis, pathophysiology, diagnosis, treatment and prevention of a range of currently topical infectious agents; this will be underpinned by a detailed knowledge of the components of the immune system and its response to the infection process. The epidemiological control of both community and healthcare associated infections will also be examined.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate an in-depth knowledge of elements constituting the innate and adaptive immune systems and the application of these systems in defence against infectious agents
  LO2: Critically evaluate current microbiological and immunological methods used in the routine diagnosis of selected infectious agents
  LO3: Explain the complex nature of the pathophysiology of selected infectious agents in key organs and tissues and how they evade the immune system
  LO4: Evaluate current and potential future strategies for the treatment and prevention of selected infectious agents
  LO5: Demonstrate an understanding of the principles of epidemiology and the control of infectious disease.
  LO6: Apply problem solving skills.
  LO7: Employ communication skills including oral presentations
  LO8: Demonstrate innovation in science through the application of knowledge.

  Skills

  Critical evaluation of the relevant scientific literature. Problem solving skills, oral and written communication skills. Time management and effective IT skills for production of poster.

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  4

  Credits

  20

  Module Code

  BIO3209

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Microbiome: Biotechnological applications and ‘Omic manipulations (20 credits)

  ×

  Microbiome: Biotechnological applications and ‘Omic manipulations

  Overview

  The objective of this module is to provide an advanced understanding on the recent developments in ‘omic’ tools to study microbiomes and their role in ecosystem function, host health and biotechnological applications. The students will learn the theoretical and applied basis of ‘omic’ tools (e.g. genomics, meta-genomics/bolomics/proteomics) with lectures suited for different pathways. Case studies will be used to enhance the learning outcomes for students by demonstrating how the microbiome tools can be effectively used to study and manipulate communities. Students will also be trained on how to analyse big datasets (omics), identify appropriate bioinformatics pipelines and in the interpretation of results.

  Learning Outcomes

  LO1 Demonstrate in depth knowledge of microbiome tools
  LO2 Critically discuss the strengths and caveats of different tools
  LO3 Evaluate and synthesise scientific literature
  LO4 Demonstrate the ability to identify knowledge gaps in microbiome-related research
  LO5 Apply problem solving skills and identify future strategies
  LO6 Demonstrate the ability to analyse datasets and critically interpret the results

  Skills

  Problem solving skills, IT skills for basic bioinformatics, critical evaluation of scientific literature and written communication skills

  Coursework

  40%

  Examination

  60%

  Practical

  0%

  Stage/Level

  4

  Credits

  20

  Module Code

  BIO3203

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Zoonoses (20 credits)

  ×

  Zoonoses

  Overview

  Overall the module objective is to impart knowledge acquired from the latest research on zoonoses, from both human and animal medicine providing a comprehensive understanding of the direct and indirect impact of zoonotic diseases, including their epidemiology, pathology, treatment and control. The expansion of disease and disease vectors as a result of climate change will also be examined, as will the importance of emerging diseases. The impact of these diseases will also be examined upon conservation.

  Learning Outcomes

  Upon completion of the module students should have gained a broad knowledge and understanding of zoonotic diseases ranging from bacterial, protozoan and viral to metazoan parasites and the socio-economic impact that the control and sporadic outbreak of these diseases have, as well as the conservation impact. The module will, (a) enable students to define/discuss the main concepts necessary to understand zoonoses, assessment of the associated risks of the diseases and the different methods of control employed; (b) highlight the interdisciplinary approach necessary for diagnosis, control and eradication of contagious diseases (microbiology, parasitology, veterinary and human health, molecular biology, genetics, ecology, social sciences, etc.) and apply this to specific zoonotic diseases. Learning outcomes will be assessed through both written examination and continuous assessment.

  Skills

  Written communication.
  Critical assessment of research literature. Report writing. Essay writing.

  Coursework

  20%

  Examination

  80%

  Practical

  0%

  Stage/Level

  4

  Credits

  20

  Module Code

  BIO3204

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Parasitology (20 credits)

  ×

  Parasitology

  Overview

  Objectives: Parasites continue to have a profound negative impact on the health and economy of the world. This course aims to promote an awareness and understanding of the biology (behaviour, biochemistry, genetics, immunology and physiology) of parasites and host-parasite interactions, and to examine the application of this knowledge to parasite management and the control of parasite disease.

  Learning Outcomes

  On completion of this course, students are expected to have gained a broad understanding of the biology of protozoan, helminth and arthropod parasites. In particular, a detailed insight into the behaviour, biochemistry, molecular biology and physiology of helminth parasites will be attained. Students will be aware of the value of model worms to Parasitology research and should be able to integrate information on parasite biology and host-parasite interaction with developments in the treatment and control of parasite disease; this is assessed through diverse continuous assessment elements. Students are expected to have developed written communication skills through essay writing and report writing.

  Skills

  Students are expected to have developed written communication skills through essay writing as well as an understanding of the impact of parasites on human and animal health. They also will learn to interrogate and evaluate primary and secondary scientific literature.

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  4

  Credits

  20

  Module Code

  BIO3107

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Research Project (40 credits)

  ×

  Research Project

  Overview

  This module allows students to complete an independent piece of research that is allied to their programme pathway, employment aspirations and specific academic interests. The final year allows choice from a range of specialised topics that are informed and inspired by the research being carried out in the School of Biological Sciences. This module will provide an understanding of how to conduct an independent, hypothesis driven research project. It allows the student to: find, evaluate and synthesise information from a variety of sources; apply their skills of critical analysis to a ‘real world’ research and apply awareness of ethics/legal/policy aspects in context in the field of Biological Science. This module must be passed in order for students to be awarded a BSc Honours Degree.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate the ability to analyse problems in their field, formulate hypotheses, evaluate and apply evidence-based solutions.
  LO2: Plan, carry-out and report on a relevant scientific investigation including the application of health and safety procedures and ethical considerations in research.
  LO3: Demonstrate critical analysis of literature and data collected either in the laboratory, field or collated from published sources.
  LO4: Innovatively apply their skills to tackling relevant scientific problems.
  LO5: Demonstrate effective time-keeping, self-management and the ability to work independently.
  LO6: Demonstrate an appreciation of the limits and significance of scientific findings.
  LO7: Effectively communicate knowledge of the biological sciences to both a scientific audience and the general public.
  LO8: Demonstrate understanding of Good Laboratory Practice (GLP).
  LO9: Effectively execute laboratory practical and analytical skills.

  Skills

  Plan, carry out and report a relevant scientific investigation. Time-management skills, initiative and independence. Ability to carry out a risk assessment of a project, appreciate the need to work safely and ethically. Effective IT skills, including Word Processing, retrieval of
  information from electronic databases, data analysis and where appropriate statistical analysis

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  4

  Credits

  40

  Module Code

  BIO3308

  Teaching Period

  Full Year

  Duration

  24 weeks

  Pre-requisite

  No

  Core/Optional

  Core