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Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer

Bankhead P, Fernández JA, McArt DG, Boyle DP, Li G, Loughrey MB, Irwin GW, Harkin DP, James JA, McQuaid S, Salto-Tellez M, Hamilton PW.

Lab Invest. 2018 Jan;98(1):15-26. doi: 10.1038/labinvest.2017.131. Epub 2017 Dec 18.

PMID:29251737

DOI: 10.1038/labinvest.2017.131 

Professor Manuel Salto-Tellez or Dr Jackie James, Queen’s University Belfast

salto-tellez@qub.ac.uk

james@qub.ac.uk

RNAscope in situ hybridization confirms mRNA integrity in formalin-fixed, paraffin-embedded cancer tissue samples

Bingham V, McIlreavey L, Greene C, O'Doherty E, Clarke R, Craig S, Salto-Tellez M, McQuaid S, Lewis C, James J.

Oncotarget. 2017 Oct 16;8(55):93392-93403. doi: 10.18632/oncotarget.21851. eCollection 2017 Nov 7

PMID:29212158

PMCID:PMC5706804

DOI:10.18632/oncotarget.21851

Professor Manuel Salto-Tellez or Dr Jackie James, Queen’s University Belfast

salto-tellez@qub.ac.uk

james@qub.ac.uk

QuPath: Open source software for digital pathology image analysis

Bankhead P, Loughrey MB, Fernández JA, Dombrowski Y, McArt DG, Dunne PD, McQuaid S, Gray RT, Murray LJ, Coleman HG, James JA, Salto-Tellez M, Hamilton PW.

Sci Rep. 2017 Dec 4;7(1):16878. doi: 10.1038/s41598-017-17204-5.

PMID:29203879

PMCID:PMC5715110

DOI:10.1038/s41598-017-17204-5

Professor Manuel Salto-Tellez or Dr Jackie James, Queen’s University Belfast

salto-tellez@qub.ac.uk

james@qub.ac.uk

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival

Alderdice M, Dunne PD, Cole AJ, O'Reilly PG, McArt DG, Bingham V, Fuchs MA, McQuaid S, Loughrey MB, Murray GI, Samuel LM⁶, Lawler M, Wilson RH, Salto-Tellez M, Coyle VM.

Mod Pathol. 2017 Sep;30(9):1287-1298. doi: 10.1038/modpathol.2017.47. Epub 2017 Jun 16.

PMID:28621318

DOI:10.1038/modpathol.2017.47

Professor Manuel Salto-Tellez, Queen’s University Belfast

salto-tellez@qub.ac.uk

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted  and immune checkpoint inhibitor therapies

Alvi MA, Loughrey MB, Dunne P, McQuaid S, Turkington R, Fuchs MA, McGready C, Bingham V, Pang B, Moore W, Maxwell P, Lawler M, James JA, Murray GI, Wilson RH, Salto-Tellez M.

Br J Cancer. 2017 Jul 11;117(2):203-209. doi: 10.1038/bjc.2017.168. Epub 2017 Jun 8.

PMID:28595259

PMCID:PMC5520517

DOI:10.1038/bjc.2017.168

Professor Manuel Salto-Tellez or Dr Jackie James, Queen’s University Belfast

james@qub.ac.uk

salto-tellez@qub.ac.uk

Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study

Gray RT, Loughrey MB, Bankhead P, Cardwell CR, McQuaid S, O'Neill RF, Arthur K, Bingham V, McGready C, Gavin AT, James JA, Hamilton PW, Salto-Tellez M, Murray LJ, Coleman HG.

Br J Cancer. 2017 Jun 6;116(12):1652-1659. doi: 10.1038/bjc.2017.139. Epub 2017 May 1

PMID:28524155

PMCID:PMC5518863

DOI:10.1038/bjc.2017.139

Professor Manuel Salto-Tellez or Dr Jackie James, Queen’s University Belfast

james@qub.ac.uk

salto-tellez@qub.ac.uk

Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study

Gray RT, Cantwell MM, Coleman HG, Loughrey MB, Bankhead P, McQuaid S, O'Neill RF, Arthur K, Bingham V, McGready C, Gavin AT, Cardwell CR, Johnston BT, James JA, Hamilton PW, Salto-Tellez M, Murray LJ.

Clin Transl Gastroenterol. 2017 Apr 27;8(4):e91. doi: 10.1038/ctg.2017.18.

PMID:28448072

PMCID:PMC5543466

DOI:10.1038/ctg.2017.18

Professor Manuel Salto-Tellez or Dr Jackie James, Queen’s University Belfast

james@qub.ac.uk

thomas@soton.ac.uk

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype through Inhibition of NOX4

Hanley CJ¹, Mellone M¹, Ford K¹, Thirdborough SM¹, Mellows T¹, Frampton SJ¹, Smith DM¹, Harden E¹, Szyndralewiez C¹, Bullock M¹, Noble F¹, Moutasim KA¹, King EV¹, Vijayanand P¹, Mirnezami AH¹, Underwood TJ¹, Ottensmeier CH¹, Thomas GJ¹. 

J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx121.

PMID: 28922779

PMCID: PMC5903651

DOI: 10.1093/jnci/djx121 

Prof Gareth Thomas, University of Southampton

thomas@soton.ac.uk

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

Ganesan AP, Clarke J, Wood O, Garrido-Martin EM, Chee SJ, Mellows T, Samaniego-Castruita D, Singh D, Seumois G, Alzetani A, Woo E, Friedmann PS, King EV, Thomas GJ, Sanchez-Elsner T, Vijayanand P, Ottensmeier CH.

Nat Immunol. 2017 Aug;18(8):940-950. doi: 10.1038/ni.3775. Epub 2017 Jun 19.

PMID:28628092

DOI:10.1038/ni.3775 

Prof Gareth Thomas, University of Southampton

thomas@soton.ac.uk