Modules

• Year 1

  Core Modules

  World of Microorganisms (20 credits)

  ×

  World of Microorganisms

  Overview

  The World of Microorganisms (BIO1301) is a 20 CAT module that is underpinned by the semester 1 module ‘Fundamentals of Microbiology’. In this module students will explore: microbial interactions examining their role in food, health and the environment; study aspects of microbial pathogenicity in humans and animals and their impact on the immune system; and learn about some aspects of microbial biotechnology. Case studies will be used to relate learning to real-world context.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Describe and explain how microorganisms relate to production and use of food
  
  LO2: Discuss aspects of biogeochemistry including marine microbiology’s role in maintaining a healthy Earth
  
  
  LO3: Discuss microbial adaptations to extreme environments
  
  LO4: Demonstrate the biotechnological potential of microorganisms for the benefit of humankind.
  
  LO5: Discuss how microorganisms may contribute to the manifestation of disease and how this can be prevented
  
  LO6: Demonstrate competence in microbiology specific laboratory practical and manipulative skills.
  
  LO7: Demonstrate Good Laboratory Practice (GLP), and appropriate health and safety in the laboratory and ethical practices.
  
  LO8: Develop problem solving skills and the ability to analyse data.
  
  LO9: Demonstrate the ability to work as part of a team.

  Skills

  By the end of the module, students should have developed competence in practical laboratory skills related to microbiology, as well as reading, numerical, and scientific problem-solving skills. In addition to effective assimilation of knowledge they will gain experience of word processing, numerical procedures, interpretation of data, team working and problem solving.

  Coursework

  15%

  Examination

  60%

  Practical

  25%

  Stage/Level

  1

  Credits

  20

  Module Code

  BIO1301

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Genetics and the Molecular Toolbox (20 credits)

  ×

  Genetics and the Molecular Toolbox

  Overview

  Genetics and the Molecular Toolbox is a Stage 1 20 CAT module that runs in semester 2. The module provides a comprehensive introduction to the concepts of Genetics from fundamental to applied and builds on the knowledge gained through BIO1103 Molecular Basis of Life. Students will develop broad knowledge of genetics, genomics, and associated molecular tools and technologies. The course begins with an introduction classical genetics (chromosome structure, cytogenetics, diploid inheritance, allelic and epistatic interactions, aneuploidy, polyploidy, cytoplasmic inheritance) and population genetics to understand the importance of natural selection and evolutionary processes. This will be followed by the introduction to modern genetics tools and molecular techniques through a series of Toolbox sessions. Focus will be on ‘omics technologies including bioinformatics, and practical methods in molecular and cellular biology including genetic engineering tools and biochemistry techniques. The applications of genetic engineering, biotechnology, and tools/assays will be explored in the form of case studies. Students will also gain an understanding of the genetic/molecular basis of disease.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate knowledge and understanding of the molecular basis of genetics (classical, population and evolutionary)
  
  LO2: Demonstrate understanding of bioinformatics and how to use software to interrogate datasets
  
  LO3: Describe recent advances in genetic, molecular, and biochemical tools including genetic manipulation and ‘omics’ technologies
  
  LO4: Discuss the applications of genetics and genetic tools to biotechnology, medicine and scientific research
  
  LO5: Develop problem solving skills and the ability to analyse data.
  
  LO6: Demonstrate Good Laboratory Practice (GLP), and appropriate health and safety in the laboratory and ethical practices.
  
  LO7: Demonstrate competence in specific laboratory practical and manipulative skills
  
  LO8: Develop an awareness of steps required to translate basic scientific research into commercial and/ or practical applications

  Skills

  Development of laboratory skills related to genetics and its applications as evidenced through Practical Skills Portfolio; Report writing; Critical and logical analysis of data; Computational analyses of genome/transcriptome data

  Coursework

  15%

  Examination

  60%

  Practical

  25%

  Stage/Level

  1

  Credits

  20

  Module Code

  BIO1304

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Fundamentals of Microbiology (20 credits)

  ×

  Fundamentals of Microbiology

  Overview

  Fundamentals of Microbiology provides a practical and theoretical introduction to the biology of microorganisms that are unicellular, multicellular or acellular (without cells). This includes microbes like bacteria, viruses, fungi, algae, protozoa and parasites. Students will explore the history of microbiology and gain an appreciation that diversity of life on earth is the result of evolution. Topics covered include: microbial taxonomy; microscopy; morphology and function of prokaryotic cells; bacterial growth and nutrition; and bacterial genetics. Students will also be introduced to mycology, virology and parasitology.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Describe and explain the basic structure and function of important examples of bacteria, archaea, viruses, fungi, together with protozoan and metazoan parasites.
  
  LO2: Demonstrate an understanding organismal biology including the diversity of life and its evolution.
  
  LO3: Demonstrate knowledge of microscopy and specimen preparation.
  
  LO4: Demonstrate an understanding of microbial genetics, growth and nutritional requirements
  
  LO4: Develop an understanding of Good Laboratory Practice (GLP), health and safety in the laboratory and ethical practice.
  
  LO6: Develop problem solving skills and the ability to analyse data.
  
  LO7: Develop communication skills including essay writing.
  
  LO8: Demonstrate competence in microbiology specific laboratory practical and manipulative skills.

  Skills

  By the end of the module, students should have developed competence in practical laboratory skills related to microbiology, as well as reading, numerical, and scientific problem-solving skills. In addition to effective assimilation of knowledge they will gain experience of word processing, numerical procedures, presentation and interpretation of data, team working, problem solving and written communication skills.

  Coursework

  80%

  Examination

  0%

  Practical

  20%

  Stage/Level

  1

  Credits

  20

  Module Code

  BIO1314

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Molecular Basis of Life (20 credits)

  ×

  Molecular Basis of Life

  Overview

  The Molecular Basis of Life (BIO1103) is a 20 CAT module that provides a comprehensive introduction to the molecular basis of life from the molecular level through to cells, tissues, and whole organisms. This module broadly covers biochemistry, molecular biology, and energy metabolism in the context of life of earth. The course begins with an introduction to the chemical context of life (elements, compounds, molecules, atoms, bonding and thermodynamics) and biomolecules (amino acids, proteins, nucleic acids, carbohydrates, lipids), to include the molecular and biochemical processes which underpin life on earth (DNA replication, RNA transcription and translation, genetic code and mutation, protein biochemistry, enzyme kinetics, glucose metabolism, metabolism control, and photosynthesis). Students are introduced to basic cell structure and communication to facilitate exploration of life at all levels and in different environmental conditions and allow understanding of the evolutionary scales of biological systems. Students receive practical teaching in key laboratory skills, DNA extraction, amino acid titration, enzyme kinetics, and photosynthesis. Students will be trained in basic laboratory mathematics including molar calculations and key mathematical concepts/theories. Students will also receive teaching in laboratory Health and Safety regulations and will be instructed in Good Laboratory Practice.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate knowledge and understanding of the chemistry of life and its application to biological sciences.
  LO2: Demonstrate a knowledge and understanding of biodiversity and organismal biology in the context of biochemical processes that govern life on earth.
  LO3: Describe and explain the structures, roles and activities of the major biological molecules, sub-cellular components and cell types.
  LO4: Develop problem solving skills and the ability to analyse data.
  LO5: Develop written communication skills including report writing.
  LO6: Develop an understanding of Good Laboratory Practice (GLP), health and safety in the laboratory and ethical practice.
  LO7: Demonstrate competence in specific laboratory practical and manipulative skills.
  LO8: Demonstrate the ability to work as part of a team and reflect on their role in the team.

  Skills

  Development of laboratory skills related to molecular biology, biochemistry and energy metabolism as evidenced through practical skills portfolio; report writing; critical and logical analysis of data, peer and self-assessment

  Coursework

  65%

  Examination

  0%

  Practical

  35%

  Stage/Level

  1

  Credits

  20

  Module Code

  BIO1103

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Structure, Reactivity and Mechanism in Organic and Bioorganic Chemistry (20 credits)

  ×

  Structure, Reactivity and Mechanism in Organic and Bioorganic Chemistry

  Overview

  Dr Paul Dingwall
  p.dingwall@qub.ac.uk
  Carbonyl Chemistry and Acidity (6 Lectures, Seminar)
  
  Module Coordinator, Laboratory Coordinator
  Dr. Chris Murgnaghan
  c.murgnaghan@qub.ac.uk
  Infrared, NMR and Mass Spectroscopy (6 Lectures, Seminar);
  Aromaticity and Aromatic Chemistry (6 Lectures, Seminar)
  
  Dr Mark McLaughlin
  m.mclaughlin@qub.ac.uk
  Oxidation And Reduction REDOX Processes (6 Lectures, Seminar)
  
  Dr Stephen Cochrane
  s.cochrane@qub.ac.uk
  Organic Chemistry Workshops (3 x 2h Workshops)
  SEMESTER 2
  
  INFRARED, NMR AND MASS SPECTROSCOPY (Dr C. Murgnaghan):
  • The electromagnetic spectrum. Energy absorption.
  • IR Spectroscopy
  • Hooke's Law approximation, stretching and bending vibration modes.
  • R spectrometers.
  • Characterisation by IR spectroscopy - group frequencies, finger print region. * Specific group frequencies - C-H stretch, (bend), C=C and C=C stretch, O-H stretch, N-H stretch, C=O stretch (and factors affecting it), C=N stretch, o-, m-, p-bend in mono- and disubstituted benzene derivatives.
  • Uses of IR spectroscopy.* A Brief Introduction to 1H NMR Spectroscopy* The Nuclear Magnetic Resonance (NMR) Spectrometer.
  • Examples of 1H NMR spectra of various small organic molecules.
  • The concepts chemical shift variation; shielding and deshielding effects. Spin-Spin Splitting and the (n+1) rule.
  • Applications of spectroscopic methods in structure identification.
  
  AROMATICITY AND AROMATIC CHEMISTRY(Dr C. Murgnaghan):
  • The Huckel Rule of Aromaticity
  • The bonding in benzene: concepts of resonance, delocalisation and aromatic stabilisation. *
  • Nomenclature of substituted aromatics.
  • Electrophilic Aromatic Substitution Reactions: mechanisms and prominent (name) reactions: nitration, halogenation, acylation, and alkylation.
  • Directing Effects in Electrophilic Aromatic Substitution Reactions.
  • Aromatic amines and diazonium salts: preparation and reactions of.
  • Electrophilic substitution of heteroaromatic compounds.
  • Diazotisation of aniline, Nucleophilic substitution of diazonium species. Preeparation of phenols.
  • Synthesis and strategies in preparation of polysubstituted benzenes.
  
  CARBONYL CHEMISTRY AND ACIDITY (Dr P. Dingwall)
  • Develop an understanding of the pKa and pKaH scales.
  • Appreciate how the pKaH scale can be used to determine nucleophile strength and leaving group ability.
  • Reason through the factors that affect the stability of a conjugate base and appreciate how to use this knowledge to predict approximate pKa values and positions of equilibrium.* Understand factors that govern nucleophilic addition to the carbonyl group.
  • Understand the differences between acid and base catalysed mechanisms.
  • Understand factors that govern nucleophilic substitution at the carbonyl group.
  • Be able to predict whether a nucleophilic substitution to a carbonyl group is likely to proceed.
  • Appreciate the differences in reactivity of α,β-unsaturated carbonyl compounds
  • Understand the factors that control the regioselectivity of 1,2- vs 1,4-addition in such α,β-unsaturated systems
  • Understand the impact of kinetic and thermodynamic control in organic reactions.
  
  OXIDATION AND REDUCTION REDOX PROCESSES (Dr Mark McLaughlin):
  • Definition of REDOX processes.
  • Functional group interconversions based on REDOX processes.
  • Classes of oxidants including oxygen, ozone, N-oxides, peroxides, peroxyacids, transition metal and p-block elements in high oxidation states.
  • Classes of reductants including hydrogen, hydrides of boron and aluminium, and electropositive elements such as sodium and magnesium.
  
  ORGANIC CHEMISTRY WORKSHOPS (Dr Stephen Cochrane):
  • Practice and application of all the chemistry covered in this course

  Learning Outcomes

  On completion of this module the students will have gained a theoretical and practical understanding of basic Organic Chemistry. They will be able to relate organic chemistry to pharmaceutical and biological subjects.

  Skills

  Learners are expected to demonstrate the following on completion of the module:
  •You will learn how to take good notes from lectures.
  •You will begin to understand the principles of mechanistic organic chemistry and ‘curly-arrow’ pushing, and learn the basic language that we speak in the organic chemistry world.
  •You will learn how to preform functional group interconversions build simple acyclic molecules from simple, readily-available organic chemical starting materials and basic chemical feedstocks.
  •You will become familiar with how to perform organic chemical reactions in the laboratory.

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  1

  Credits

  20

  Module Code

  CHM1004

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Fundamentals of Chemistry (20 credits)

  ×

  Fundamentals of Chemistry

  Overview

  STAFF
  
  NAME CONTRIBUTION
  
  Dr A. C. Marr a.marr@qub.ac.uk
  Module Co-ordinator
  General Chemistry - 18 Lectures; Skills Workshops – part 1, Essential Calculations for Practical Chemistry
  Dr P. C. Marr p.marr@qub.ac.uk
  Skills workshop – Laboratory Skills parts 1 and 2
  Prof. P. Stevenson p.stevenson@qub.ac.uk
  Organic Chemistry: Functional Group Chemistry 15 Lectures, 5 Seminars Organic Chemistry Laboratory
  Dr P. Dingwall p.dingwall@qub.ac.uk
  Organic Chemistry Laboratory
  Dr M. Swadzba-Kwasny Swadzba-kwasny@qub.ac.uk
  Skills workshop – Scientific writing and researching skills.
  
  Course content
  
  General Chemistry - Elements, Atoms, ions, electrons and the periodic table. This course aims to give an introduction to the fundamental principles of atoms from the chemists’ viewpoint. Starting from a simple model and using the results of quantum mechanics a more appropriate model of the atom is presented. From this model trends in atomic and ionic properties which enable us to explain differences and similarities and predict the properties of different elements can be deduced. The following topics are covered:
  * The Basics: Element, The periodic table, atom, mole.
  * The Atom: The Bohr Atom.
  * The Electron: Wave-Particle Duality and The Schrödinger Wave Equation, Probability Density, Radial Distribution Function, Orbitals, Quantum Numbers, s and p Orbitals, Phase, d Orbitals.
  * More than One Electron: Filling orbitals, The aufbau principle, The Pauli Exclusion Principle, Hund’s rules, Penetration, Shielding, Effective Nuclear Charge, Slater’s Rules, Size.
  * Trends: Ionization energy, Electron attachment enthalpy (affinity), Electronegativity, Ionic radii, Polarizability and polarizing power, Hydration enthalpies, Redox potentials. General Chemistry - Structure and Bonding. This course introduces some important theories of bonding. Theories of bonding are discussed in some detail for discrete molecules. The discussion of bonding in molecular species centres on the valence bond and molecular orbital theories. Intermolecular forces between molecules are also discussed.
  * Introduction to bonding: Discussion of types of structure and common bonding theories, examples of representative structures.
  * Homonuclear Diatomic Molecules: Interatomic distance and covalent radii, Potential energy curves, attractive and repulsive forces, bond energy and enthalpy. Lewis structures, filled shells, the octet rule. Wavefunction, introduction to valence bond theory and molecular orbital theory, Valence bond theory: ionic and covalent contributions, resonance; Molecular orbital theory: molecular orbitals, linear combinations of atomic orbitals, orbital overlap, bonding and antibonding orbitals, MO diagrams, some shapes of MO’s, labelling MO’s, examples of simple MO diagrams, bond order.
  * Heteronuclear Diatomic Molecules: Lewis structures, valence bond approach, Molecular orbital theory, energy matching, symmetry, non-bonding orbitals; electronegativity, electric dipole moments, carbon monoxide, isoelectronic molecules.
  * Polyatomic Molecules: Metal complexes and covalent polyatomics, coordination number, common geometries, molecules obeying the octet rule, valence bond theory, expanding the octet, hybridization (sp, sp2, sp3), formal charge, single, double and triple carbon-carbon bonds, molecular shapes; molecular orbital theory: ligand group orbitals; comparison of VB and MO, macromolecules, fullerenes, proteins and hydrogen bonding.
  * Intermolecular Forces: Van-der-Waal forces, strength of forces.
  * Introduction to solids with extended structures: metals and semi-metals, ionic solids and covalent solids. Only covered if time permits. ORGANIC CHEMISTRY: Functional Group Chemistry
  * Draw structural formula to represent organic compounds, identify isomers and convert structural formula to molecular formula.
  * Identify common organic functional groups, name organic compounds containing these groups, and predict their chemistry and reactivity.
  * Recognise nucleophiles, electrophiles and bases and identify which chemistry these species participate in. Appreciate the importance of acidity and basicity in organic chemistry
  * Sketch substitution, elimination and addition mechanisms and appreciate the importance of ‘mechanism’ in rationalising organic chemical reactions. * Suggest reagents for interconverting one functional group into another. * The functional groups which will be used to illuminate these outcomes are alkanes, alcohols, amines, alkyl halides, alkenes, alkynes, carbonyls compounds including aldehydes, ketones, carboxylic acids, esters and amides.
  SKILLS WORKSHOPS:
  * Scientific writing and researching skills
  * Laboratory skills
  * Essential calculations for practical chemistry
  ORGANIC CHEMISTRY LABORATORY:
  * 3 x 3 hours laboratories with associated write-ups.

  Learning Outcomes

  Students will become familiar with chemical descriptions of matter. What matter is made up of, how it can be organised into the periodic table and how we can start to understand it from a scientific perspective. They will learn about organic compounds and how they can be prepared, named and reacted.

  Skills

  Learners are expected to demonstrate the following on completion of the module:
  * Ability to write and predict atomic structure and properties.
  * Ability to explain and understand bonding.
  * Ability to recognise functional groups in organic chemistry and name compounds.
  * Ability to suggest reagents, mechanisms and reactions in organic chemistry.
  * Ability to demonstrate fundamental skills in laboratory practice and associated calculations.

  Coursework

  50%

  Examination

  0%

  Practical

  50%

  Stage/Level

  1

  Credits

  20

  Module Code

  CHM1011

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

• Year 2

  Core Modules

  Microbial Metabolism and Biocatalysis (20 credits)

  ×

  Microbial Metabolism and Biocatalysis

  Overview

  1. Aspects of microbial metabolism, especially pertaining to environmental nutrient cycles.
  2. Introduction to gene mining from microbial metagenomes
  3. Aspects of protein engineering including directed evolution
  4. Application of enzymes and proteins to biotechnology applications, including biocatalysis.

  Learning Outcomes

  1. Understand how some recent concepts in bioprocesses have impact across industrial & environmental applications.
  2. Appreciate the interdisciplinary nature of modern biotechnology, especially the interplay of microbial metabolism and environmental biotechnology.
  3. Be able to translate fundamental science discoveries into technology innovation in the field of biocatalysis.
  4. Demonstrate scientific writing skills.
  5. Analyse gene/protein sequence data in a biocatalysis context using bioinformatics tools (through lab based learning).
  6. Develop critical skills in molecular analysis of microbial proteins and related biochemical pathways that can be applied to solve real world technical problems.

  Coursework

  0%

  Examination

  60%

  Practical

  40%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2311

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Advanced Cell Biology (20 credits)

  ×

  Advanced Cell Biology

  Overview

  This module builds on the fundamental coverage of cell biology that is delivered in pre-requisite module BIO2104 (i.e. cell structure and function from the perspective of individual organelles, and their interactions, and how disease can arise when these break down).
  
  In BIO2304 we focus on cutting edge techniques that can be used to investigate cell function at a variety of levels including:
  Cell culture
  Fluorescence microscopy
  Transmission and scanning electron microscopy
  RNAi / CRISPR
  Proteomics
  Inhibitors and drug development pipelines
  
  We highlight how the use of these tools can provide a better understanding of disease mechanisms and aid the development of new treatment options. Case studies include:
  Cancer cell biology
  Stem cell research
  Neurones and neurotransmitters

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate an understanding of the theoretical basis of classical and emerging technologies that are used to study cells.
  LO2: Appreciate how these tools can provide a deeper understanding of cell function and disease mechanisms.
  LO3: Discuss how advances in technology is driving research into new therapeutic strategies for various diseases.
  LO4: Appreciate the importance of experimental approach and apply practical cell biology methodologies.
  LO5: Demonstrate scientific communication skills including report writing and peer discussion.
  LO6: Demonstrate the ability to work as part of a team and reflect on their role in the team.
  LO7: Appreciate health and safety in the laboratory and ethical practice.
  LO8: Develop independent learning, critical thinking and problem solving ability.

  Skills

  Observation, recording, data analysis, microscopy, image analysis and experimental design. Practical skills in laboratory investigations including use of specialised software in data analysis, professional technical report writing and team-work.
  
  -------------------

  Coursework

  0%

  Examination

  60%

  Practical

  40%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2304

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Experimental Biochemistry (20 credits)

  ×

  Experimental Biochemistry

  Overview

  Introduction to the Biochemistry Laboratory, General Laboratory Procedures, Chromatography Techniques, Electrophoresis, Centrifugation in Biochemical Research
  Radioisotopes in Biochemical Research, UV/vis, fluorescence and CD spectroscopy, Mass Spectrometry, X-ray crystallography, Protein crystallisation, Biochemical thermodynamics, Biomolecular Interactions, Enzyme Kinetics, Immunological techniques, and Application of computers in biochemistry.

  Learning Outcomes

  Upon successful completion of this module students will be able to:
  
  LO1: Describe and explain the principles and theory of key experimental techniques used in biochemistry
  LO2: Develop key practical skills in specific analytical techniques.
  LO3: Apply a broad knowledge of theoretical and practical concepts to evaluate the significance of experimental/scientific data.
  LO4: Develop problem solving skills.
  LO5: Develop communication skills including practical report writing.
  LO6: Develop and understanding of Good Laboratory Practice (GLP)

  Skills

  Competence in the laboratory, including the ability to plan and execute an experiment and to evaluate and interpret the resulting data. Competence in critically evaluating experimental data. Awareness of the importance of working safely in the laboratory in accord with Health and Safety protocols and good working practices.

  Coursework

  40%

  Examination

  0%

  Practical

  60%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2102

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Molecular Genetics and Bioinformatics II (20 credits)

  ×

  Molecular Genetics and Bioinformatics II

  Overview

  This module covers genome mutations and repair, transcriptome sequencing, transcription in prokaryotes, transcription in eukaryotes and transcriptional control/epigenetics. This module builds on material covered in Molecular Basis of Life and World of Microorganisms (Level1) and Molecular Genetics and Bioinformatics I. Teaching is delivered via lectures and a hands on bioinformatics practical. The course is designed to prepare students for Level 3 courses such as Bacterial Genetics & Genetic Manipulation, and Immunology and Immunotherapy and for the Honours research projects that involve molecular biology and bioinformatics analysis.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate an understanding of genomic mutations and repair mechanisms
  LO2: Demonstrate understanding of transcriptome sequencing (RNAseq)
  LO3: Demonstrate competence in investigation of coding SNPs (RNAseq)
  LO4: Demonstrate competence in differential gene expression analysis (RNAseq)
  LO5: Demonstrate an understanding of gene expression in Prokaryotes
  LO6: Demonstrate an understanding of gene expression in Eukaryotes
  LO7: Demonstrate an understanding of transcriptional regulation and epigenetics
  LO8: Demonstrate problem solving ability
  LO9: Develop independent learning, critical thinking, and communication skills

  Skills

  Skills you will learn: (see further information in Practical handouts)
  • Bioinformatics skills related to transcriptomics and analysis of coding SNPs
  • Bioinformatics skills related to transcriptomics and differential gene expression analysis
  • Problem solving
  • Effective assimilation of knowledge and written communication skills

  Coursework

  40%

  Examination

  60%

  Practical

  0%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2313

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Molecular Genetics and Bioinformatics 1 (20 credits)

  ×

  Molecular Genetics and Bioinformatics 1

  Overview

  This module covers the structure and organisation of prokaryotic and eukaryotic genomes, recombinant DNA technology, protein synthesis, epigenetics, cancer genetics, genome sequencing, biological databases and application of these to the study of cancer genetics. This module builds on material covered in Molecular Basis of Life and World of Microorganisms (Level1). Teaching is delivered via lectures and corresponding hands on wet lab and bioinformatics practical work. The course is designed to prepare students for Level 3 courses such as Bacterial Genetics & Genetic Manipulation, and Immunology and Immunotherapy and for the Honours research projects that involve molecular biology and bioinformatics analysis.

  Learning Outcomes

  On successful completion of this module students will be able to:
  LO1: Demonstrate an understanding of the structure and organisation of genomes
  LO2: Demonstrate an understanding of DNA replication in prokaryotes and eukaryotes
  LO3: Demonstrate an understanding of molecular cloning
  LO4: Demonstrate an understanding of the role of epigenetic modifications, chromatin
  LO5: Demonstrate competence in molecular biology practical technique, sequence analysis, evaluation of results and report writing
  LO6: Demonstrate an understanding of protein synthesis
  LO7: Develop an understanding of the molecular genetics of cancer, Next Generation Sequencing (NGS) and it’s application to the study of cancer
  LO8: Develop independent learning, critical thinking and problem solving ability
  LO9: Demonstrate the ability to work as part of a team

  Skills

  Skills you will learn: (see further information in Practical handouts)
  • Basic skills in solution preparation, storage, and usage for molecular techniques
  • Agarose gel analysis of DNA
  • PCR
  • Restriction digestion of DNA
  • Purification of DNA
  • Cloning of PCR product into plasmid
  • Bacterial transformation
  • Identification of recombinant bacterial clones
  • Plasmid purification
  • Bioinformatics analysis of the plasmid sequencing data (NCBI, BLAST)
  • Safe working within the laboratory environment
  • Recording of data and appropriate analysis
  • Data presentation and interpretation
  • Oral and written communication skills
  • Problem solving
  • Team working
  • Effective assimilation of knowledge and written communication skills

  Coursework

  50%

  Examination

  0%

  Practical

  50%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2312

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Cell Biology (20 credits)

  ×

  Cell Biology

  Overview

  Detailed coverage of cell structure and function from the perspective of individual organelles and their interactions including:
  
  The variety of cells
  The cell cycle
  Cell Signalling
  The nucleus & the cytoplasm
  The mitochondrion & energy production
  Ribosomes & protein synthesis
  The secretory pathway
  Exosomes
  Membrane pumps and transporters
  Cytoskeleton
  Blood cells & pathologies
  
  How breakdown of normal organelle function can lead to disease and how a knowledge of cell biology has helped to develop appropriate treatments, e.g.:
  
  Cystic fibrosis
  Cancer
  Lysosomal storage diseases
  Sickle cell anaemia

  Learning Outcomes

  On successful completion of this module students will be able to
  
  LO1: Describe the structure and function of the major cell organelles and their interactions with each other.
  LO2: Demonstrate knowledge of how disease can arise when these cellular processes and interactions break down.
  LO3: Appreciate the importance of experimental approach and the practical methodologies employed in cell biology.
  LO4: Demonstrate competence in specific laboratory practical and manipulative skills.
  LO5: Develop independent learning, critical thinking and problem solving ability
  LO6: Demonstrate the ability to work as part of a team

  Skills

  Observation, recording, data analysis, microscopy, basic haematology, image analysis and experimental design. Practical skills in laboratory investigations including use of specialised software in data analysis, professional technical report writing and team-work.
  ------------------------

  Coursework

  50%

  Examination

  0%

  Practical

  50%

  Stage/Level

  2

  Credits

  20

  Module Code

  BIO2104

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

• Year 3

  Core Modules

  Professional Studies (120 credits)

  ×

  Professional Studies

  Overview

  1. Preplacement preparation including; the selection of placement,
  application forms, CV's and interviews. Evaluation of placement by student,
  including potential to relate academic theory to the work place, skills
  development and project development.
  2. On placement work including; relating academic theory to the workplace, recording activities and reflection in a log book. 3. Post placement reflection of learning and career prospects.
  
  
  
  
  1. Preplacement preparation including; the selection of placement,
  application forms, CV's and interviews. Evaluation of placement by student,
  including potential to relate academic theory to the work place, skills
  development and project development.
  2. On placement work including; relating academic theory to the workplace, recording activities and reflection in a log book. 3. Post placement reflection of learning and career prospects.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Apply subject knowledge of theoretical and practical concepts to provide solutions in the work-related environment
  LO2: Evidence development in work related transferable skills
  LO3: Manage and deliver project type work in the workplace setting
  LO4: Demonstrate employability skills and an enhanced career plan.
  LO5: Demonstrate an understanding of the importance of Health and Safety in the work environment.
  LO6: Exhibit effective communication skills in both the academic and work environment.
  LO7: Demonstrate the ability to work as part of a team and reflect on your role in the team.
  LO8: Evaluate and reflect upon your learning experience in the work environment

  Skills

  Students will identify and evaluate the skills which they have developed
  during the placement, which may include: communication (oral and written); problem-solving; team work; IT; presentational; personal development and reflection.

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  3

  Credits

  120

  Module Code

  BIO3303

  Teaching Period

  Full Year

  Duration

  40 weeks

  Pre-requisite

  No

  Core/Optional

  Core

• Year 4

  Core Modules

  Microbiome: Biotechnological applications and ‘Omic manipulations (20 credits)

  ×

  Microbiome: Biotechnological applications and ‘Omic manipulations

  Overview

  The objective of this module is to provide an advanced understanding on the recent developments in ‘omic’ tools to study microbiomes and their role in ecosystem function, host health and biotechnological applications. The students will learn the theoretical and applied basis of ‘omic’ tools (e.g. genomics, meta-genomics/bolomics/proteomics) with lectures suited for different pathways. Case studies will be used to enhance the learning outcomes for students by demonstrating how the microbiome tools can be effectively used to study and manipulate communities. Students will also be trained on how to analyse big datasets (omics), identify appropriate bioinformatics pipelines and in the interpretation of results.

  Learning Outcomes

  LO1 Demonstrate in depth knowledge of microbiome tools
  LO2 Critically discuss the strengths and caveats of different tools
  LO3 Evaluate and synthesise scientific literature
  LO4 Demonstrate the ability to identify knowledge gaps in microbiome-related research
  LO5 Apply problem solving skills and identify future strategies
  LO6 Demonstrate the ability to analyse datasets and critically interpret the results

  Skills

  Problem solving skills, IT skills for basic bioinformatics, critical evaluation of scientific literature and written communication skills

  Coursework

  40%

  Examination

  60%

  Practical

  0%

  Stage/Level

  4

  Credits

  20

  Module Code

  BIO3203

  Teaching Period

  Spring

  Duration

  12 weeks

  Pre-requisite

  Yes

  Core/Optional

  Core

  Biomolecules in Health and Disease (40 credits)

  ×

  Biomolecules in Health and Disease

  Overview

  The module is focused on the four main classes of biomolecules (nucleic acids, proteins, lipids and carbohydrates) and how these each contribute to the health of organisms and, if dysfunctional, in disease states. Teaching on this module is research-informed, with lecture material delivered by research active experts in each of these fields. Students will examine in depth the structure-function relationships of nucleic acids, proteins and receptor signalling, and will illustrate the importance of the latter as drug targets. The biomolecules in disease states such as cancer will be studied as well as the roles of metals, toxins and plant metabolites in human and animal health and disease..

  Learning Outcomes

  Students on the course will:
  LO1: Evaluate and discuss current principles in biochemistry
  LO2: Demonstrate an in-depth knowledge of the chemistry, structure and function of biological molecules, the major classes of signalling molecules, their receptors and intracellular signalling pathways.
  LO3: Demonstrate an understanding of the structure and function of both prokaryotic and eukaryotic cells
  LO4: Explain the biochemical processes that underlie the relationship between genotype and phenotype
  LO5: Explain the complex nature of the pathophysiology of selected biochemical disorders
  LO6: Analyse ways of manipulating biochemical systems to prevent or treat disease.
  LO7: Apply problem solving skills.
  LO8: Employ communication skills
  LO9: Demonstrate innovation in science through the application of knowledge.
  LO10: Exhibit an awareness of bioentrepreneurship and the importance of the bioeconomy in the context of industrial and academic research settings.
  LO11: Demonstrate the ability to work as part of a team and reflect on their role in the team.

  Skills

  Critical evaluation of the relevant scientific literature, problem solving skills, written communication skills. Time management.

  Coursework

  40%

  Examination

  60%

  Practical

  0%

  Stage/Level

  4

  Credits

  40

  Module Code

  BIO3304

  Teaching Period

  Full Year

  Duration

  24 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Immunology and Immunotherapy (20 credits)

  ×

  Immunology and Immunotherapy

  Overview

  The module will look at the cellular and molecular aspects of immunology, including the innate immunity, the adaptive immunity, immunoglobulins, generation of diversity, antigen recognition, antigen processing, immunoassay design and role of cytokines in immune responses. The pathogenesis of a selected of immunological disorders and the role of immunity in protection against pathogens and cancer. The module will also explore the area of immunotherapy.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Evaluate and discuss current principles in immunology
  LO2: Demonstrate an in-depth knowledge of elements constituting the innate and adaptive immune systems
  LO3: Critically evaluate current immunological methods
  LO4: Explain the complex nature of the pathophysiology of selected immunological disorders
  LO5: Analyse ways of manipulating the immune system to prevent or treat disease including the role of immunotherapy in cancer treatment.
  LO6: Apply problem solving skills.
  LO7: Employ communication skills including oral presentations
  LO8: Demonstrate innovation in science through the application of knowledge.

  Skills

  Critical evaluation of the relevant scientific literature. Problem solving skills, oral and written communication skills. Time management and effective IT skills for production of poster.

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  4

  Credits

  20

  Module Code

  BIO3104

  Teaching Period

  Autumn

  Duration

  12 weeks

  Pre-requisite

  No

  Core/Optional

  Core

  Research Project (40 credits)

  ×

  Research Project

  Overview

  This module allows students to complete an independent piece of research that is allied to their programme pathway, employment aspirations and specific academic interests. The final year allows choice from a range of specialised topics that are informed and inspired by the research being carried out in the School of Biological Sciences. This module will provide an understanding of how to conduct an independent, hypothesis driven research project. It allows the student to: find, evaluate and synthesise information from a variety of sources; apply their skills of critical analysis to a ‘real world’ research and apply awareness of ethics/research integrity/EDI/legal/policy and financial literacy aspects in context in the field of Biological Science. This module must be passed in order for students to be awarded a BSc Honours Degree.

  Learning Outcomes

  On successful completion of this module students will be able to:
  
  LO1: Demonstrate the ability to analyse problems in their field, formulate hypotheses, evaluate and apply evidence-based solutions.
  LO2: Plan, carry-out and report on a relevant scientific investigation including the application of health and safety procedures, financial, ethical and EDI considerations in research.
  LO3: Demonstrate critical analysis of literature and data collected either in the laboratory, field or collated from published sources.
  LO4: Innovatively apply their skills to tackling relevant scientific problems.
  LO5: Demonstrate effective time-keeping, self-management and the ability to work independently.
  LO6: Demonstrate an appreciation of the limits and significance of scientific findings.
  LO7: Effectively communicate knowledge of the biological sciences to both a scientific audience and the general public.
  LO8: Demonstrate understanding of Good Laboratory Practice (GLP) and how their research aligns with UN SDGs.
  LO9: Effectively execute laboratory practical and analytical skills.

  Skills

  Plan, carry out and report a relevant scientific investigation. Time-management skills, initiative and independence. Ability to carry out a risk assessment of a project, appreciate the need to work safely and ethically. Effective IT skills, including Word Processing, retrieval of
  information from electronic databases, data analysis and where appropriate statistical analysis

  Coursework

  100%

  Examination

  0%

  Practical

  0%

  Stage/Level

  4

  Credits

  40

  Module Code

  BIO3308

  Teaching Period

  Full Year

  Duration

  24 weeks

  Pre-requisite

  No

  Core/Optional

  Core