Find a PhD Supervisor

Research Opportunities	Supervisors
Chromatin remodelers Epigenetics Cancer metastasis Proteomics Molecular cell biology Biochemistry The Patrick G Johnston Centre for Cancer Research Cancer results from failures in epigenetic control by chromatin remodelers at the level of gene transcription. The abnormal activation of epithelial to mesenchymal transition (EMT) by carcinomas is an essential hallmark of cancer metastasis that is responsible for more than 90% of cancer deaths. Our aim is to elucidate the orchestration of EMT-MET cascade by the balancing act of chromatin remodelers and epigenetic modifiers. It is anticipated that chromatin modifying compounds will emerge as the next generation of anticancer therapies.	Dr Adone Tielenius Kruythoff-Mohd Sarip
Radiobiology of targeted radionuclides (Radium-223) Clinical trials Stereotactic Radiotherapy Radiation Biology Prostate Cancer The Patrick G Johnston Centre for Cancer Research As a consultant in clinical oncology Dr.Cole is a key member of a dynamic clinical academic team enhancing research into the treatment of prostate cancer. Key avenues of research include PSMA-PET to aid prognostication and treatment of prostate cancer; better understanding of the radiobiology of targeted radionuclides and clinical trials using immunotherapy techniques and stereotactic radiotherapy. His group combines medical physics, radiation biology and clinical treatments leading to patient focused research outcomes. Effects of bone targeted radionuclides is a key focus of ongoing research.	Dr Aidan Cole
Respiratory failure in the critically ill, particularly the Acute Respiratory Distress Syndrome (ARDS) Mechanisms of tissue damage and repair in the lung Mycobacterial infection including particularly Non-Tuberculous Mycobacterial infection, and novel therapies including biological and cellular therapies to treat infection and inflammation in the lung The Wellcome-Wolfson Institute For Experimental Medicine My research focuses understanding the pathophysiological mechanisms driving alveolar inflammation and injury in ARDS (acute respiratory distress syndrome), a devastating illness causing respiratory failure in the critically ill, and exploring new therapeutic interventions in clinically relevant human models, through to clinical trials. My group’s model systems include in vitro primary human cell work, ex vivo lung tissue slice culture, ex vivo whole lung perfusion (EVLP) models and modelling alveolar inflammation in healthy volunteers by LPS inhalation. These model systems provide proof of concept of mechanisms driving inflammation, injury and repair in human lung tissue and support the progression to clinical trials. Data from these model systems have led to clinical trials in ARDS. Clinically I work in the field of mycobacterial lung infection. The non-tuberculous mycobacteria (NTM) are an increasingly common clinical problem, driving lung tissue destruction and debility. Antibiotic regimens are highly unsatisfactory, with both poor tolerability and poor bacterial clearance. Mechanisms of virulence and host response differ from TB, but are poorly understood. My group is currently establishing models of infection, along with Dr Gunnar Schroeder, Dr Anna Krasnodembskaya and Dr Beckie Ingram to investigate these, and test new antimicrobial strategies. ARDS, critical care, mycobacterial infection, NTM, epithelium, human models, clinical trials	Professor Cecilia O'Kane
Psychiatric Epidemiology Administrative Data Linkage Social Determinants Mental Ill Health Secondary Data Analysis Centre for Public Health Psychiatric Epidemiology Administrative Data Linkage Social Determinants Mental Ill Health Mental Health Common Mood Disorders Suicide Secondary Data Analysis Epidemiology; Administrative Data; Mental Health; Secondary Data Analysis	Dr Aideen Maguire
Genetic-epigenetic-transcriptomic association studies for kidney disease Multi-omic risk factors for rare disease, and common diseases with a focus in aging populations Information and communication provision for kidney disease and rare disease(s) The Patrick G Johnston Centre for Cancer Research Multi-omic factors that influence human disease, particularly kidney disease. Our laboratories are well-equipped, including high-density array scanners and next generation sequencing machines. Her team are building the NICOLA bioresource with a focus on older individuals. Whole genome sequencing rare diseases is underway as part of the NI Genomic Medicine Centre with the complementary development of an online information hub and patient-centred pathways. We hold several registries and are actively engaged in making maximal use of complex genomic information. Bioinformatics, Genetics, Epigenetics, Genomics, Transcriptomics, DNA Methylation, Kidney Disease, Rare Disease, Healthy Ageing, Chronic Diseases, Registries, Renal	Dr Amy Jayne McKnight
Cancer Epidemiology Pancreatic cancer Early detection of cancer Centre for Public Health Dr Kunzmann’s research programmes is focused on the early detection of cancers such as pancreatic cancer. His expertise includes using a range of statistical techniques to analyse large datasets (such as the UK Biobank) to investigate the use of clinical risk factors and serum biomarkers for the early detection of pancreatic cancer.	Dr Andrew Kunzmann
Multi-disciplinary Centre and acquire training on cutting edge technologies in pluripotent stem cells Molecular biology Cell signaling Coding and non-coding RNAs in the context of diabetes Cardiovascular complications The Wellcome-Wolfson Institute For Experimental Medicine Dr Margariti’s laboratory has invested on their unique expertise on cell reprogramming and induced pluripotent stem (iPS) cell technologies and they have developed patient- specific cells lines from diabetic donors in a petri dish based on fast and highly efficient approaches. To date, the group has generated more than 90 diabetic specific iPS cell lines from small volumes of patient blood. These patient-specific cells are now valuable tools to study the underlying causes and mechanisms of the pathogenesis of endothelial cell dysfunction and develop new knowledge, biomarker of diabetes and vascular complications, and discover effective therapies.	Dr Andriana Margariti
Investigation of the role of MSC exosomal miRNAs in epithelial and endothelial repair in ARDS The role of MSC mitochondrial transfer in lung regeneration The role of apoptosis in MSC therapeutic effects in ARDS The Wellcome-Wolfson Institute For Experimental Medicine Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSCs) with the particular focus on the MSC based cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill patients with no available pharmacological treatment. Our central goal is to understand how MSCs work in the context of the injury microenvironment, how MSCs modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. More recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.	Dr Anna Krasnodembskaya
Proteomics – to identify protein-protein interactions in rhinovirus-infected cells Molecular cell biology/biochemistry – to understand the role of cellular proteins in rhinovirus replication The Wellcome-Wolfson Institute For Experimental Medicine Dr Mousnier’s research is focused on investigating the molecular interactions between host cells and rhinovirus, the virus responsible for most common colds and a major cause of asthma attacks. Despite a huge burden to society, there is currently no vaccine or antiviral treatment against rhinoviruses. Her group aims to open new avenues for treatment by identifying and characterizing the role of host cell proteins essential for the replication of the virus or for the response of the host.	Dr Aurelie Mousnier
Host-pathogen interactions vaccinology pharmacology The Wellcome-Wolfson Institute For Experimental Medicine Dr Ingram’s research focuses on characterizing the lymphocytic response to bacterial infection, particularly T cells in order facilitate rational vaccine design. Recently, she has developed and interested in innate lymphoid cells (ILCs), and was the first to demonstrate that ILC3s drive the inflammatory response within the lung during acute bacterial infection, if this response is dysregulated in leads to lung injury. Dr Ingram has extensive expertise in murine in vivo infection models.	Dr Beckie Ingram
Dementia research including the role of nutrition and inflammation in neurodegeneration The utility of EEG and MEG in assisting diagnostics Large data analytics projects Centre for Public Health Our research focuses on mild cognitive impairment and dementia. Specifically we are funded to assess the role of inflammation and also nutrition in the pathogenesis of Alzheimer’s disease. We are also leading a large data analytics project of dementia in Northern Ireland and we are assessing the utility of EEG and MEG in diagnosis.	Dr Bernadette McGuinness
Epithelial biology and pathobiology – to understand and modify innate inflammatory responses of the epithelial using drug repurposing Bioinformatics and computer-learning - to model the complexity of gene interactions involved in chronic inflammation Biomarkers of diseases The Wellcome-Wolfson Institute For Experimental Medicine The innate immune system in the lung is the first defense mechanism against air-born pathogens like bacteria and viruses) and particles. The response is highly regulated to ensure timely repair and resolution of the inflammatory response. Our research focuses on the negative regulator of inflammation, called A20. A20 is significantly lower in chronic airway diseases such as Cystic Fibrosis, asthma and pulmonary fibrosis and we are investigating several regulators of A20 and identify drugs (drug repurposing) to normalize expression and function of this key protein in airway inflammation buy addressing transcriptional repressors/activators, microRNA and glucose metabolism.	Dr Bettina Schock
Health-related sciences Quantitative subject (e.g. statistics) Pharmacoepidemiology Cancer epidemiology Centre for Public Health Dr Hicks’ research interests are in the field of pharmacoepidemiology and cancer epidemiology. Her main research area draws upon large electronic healthcare databases and innovative and novel statistical methods to (1) identify commonly used medications that influence the risk of cancer and cancer outcomes and (2) evaluate the effectiveness and safety of cancer treatments. Her current research has a particular focus on urological cancers.	Dr Blánaid Hicks
Heart failure, Cardiomyopathy, Cardiac remodelling Diabetes, Hypertension, Ischaemia Biomarkers, Epigenetics, Fibrosis Global Health, mHealth The Wellcome-Wolfson Institute For Experimental Medicine Dr Watson’s research programme at QUB is primarily focused on investigating the impact that cardiovascular risk factors such as diabetes, hypertension, and inflammation have on cardiovascular remodelling, cardiac fibrosis, and heart failure. This research is very translational and spans mechanistic work (fibrosis, hypertrophy, and epigenetics) right through to biomarker discovery programmes, clinical trials, and health services research. These research activities also span into low and middle income countries, particularly sub-Saharan Africa, through a Global Health (gHealth) Research consortium that Dr Watson has developed.	Dr Chris Watson
Epidemiology Pharmacoepidemiology. Centre for Public Health Dr Cardwell is a Senior Lecturer in Medical Statistics. He has conducted studies in a wide range of areas including cancer epidemiology and childhood onset Type 1 diabetes epidemiology. Recently he has focused upon pharmacoepidemiology, conducting studies investigating the effect of medication use on cancer risk and survival.	Dr Christopher Cardwell
Nutrition and ageing research Particularly projects involving data analysis in cohort studies Clinical/community-based dietary interventions. Centre for Public Health Dr McEvoy’s research focuses on understanding the role of nutrition in age-related chronic disease, particularly cardiovascular disease and cognitive decline. Her research involves epidemiologic investigation of dietary patterns and disease risk across the life-course, and the design and evaluation of interventions targeting dietary behaviour change to improve health and well-being during ageing. Dr McEvoy is an Atlantic Fellow of The Global Brain Health Institute (University of California San Francisco and Trinity College Dublin) and a Beeson-CARDI Fellow of the American Federation of Aging Research.	Dr Claire McEvoy
Organismal and cellular metabolism Organismal biology and pathophysiology Inflammatory and Growth factor signaling and cancer Proteolysis and cancer Protein biogenesis/protein quality control and cancer Protein trafficking in the secretory pathway The Patrick G Johnston Centre for Cancer Research We are interested in understanding how trafficking and quality control processes in the secretory pathway regulate cell signaling during disease. We have a particular interest in the interplay between metabolism, inflammation and growth control of cancer cell in mammals. My lab uses a combination of cellular biochemistry and organismal physiology in our studies.	Dr Colin Adrain
Metastatic progression Pre-metastatic organ microenvironment Pathophysiology of cancer Microvascular function and tissue regeneration and remodeling resulting from both disease and treatments. The Patrick G Johnston Centre for Cancer Research Dr. Branco’s lab focuses on the role of microvasculature in cancer dissemination (metastasis). Endothelial cells are metabolically and physiologically diverse and respond to stimuli in an organ-specific fashion. Some endothelial-specific responses have been shown to modify cancer progression and disease outcome. We aim to understand how microvascular rearrangements contribute to organ function, remodelling and pre-disposition for metastatic disease. Our lab uses primary endothelial cells and in vivo models, and state-of-the-art equipment and technology to assess physiological, pathological and metabolic parameters.	Dr Cristina Branco
Cystic fibrosis Bronchiectasis Pneumonia The Wellcome-Wolfson Institute For Experimental Medicine Dr Downey’s main clinical research interest is cystic fibrosis (CF). He works with a range of colleagues that includes, clinicians, allied health professionals, a clinical research team and basic scientists to create a translational research program in CF. His focus is to optimise clinical response to established and new therapies. He leads an active investigator-initiated and pharmaceutical-sponsored research program to help realise this. This is supported by national and international collaborative research networks.	Dr Damian Downey
Integrative analytics & software design Insights into patient heterogeneity AI Machine Learning The Patrick G Johnston Centre for Cancer Research My research focus is in the field of bioinformatics in areas relating to data integration and evolution using next generation sequencing data, among others. I also have an interest in the application of AI methods in cancer research and how we can extract new meaning from ‘big data’. I have a special focus in brain tumour research and have interactions on several clinical trials examining new treatment options for patients having typically a poor clinical outcome.	Dr Darragh McArt
Cardiovascular disease, heart failure, physiology and pharmacology from candidates with a basic science or clinical background. Previous research experience is desirable although not essential. The Wellcome-Wolfson Institute For Experimental Medicine My research programme is focussed on investigating mechanisms underlying cardiovascular disease and heart failure, with a particular interest in the influence of oxidative stress and diabetes. My group employs a wide range of laboratory techniques, from in vivo physiology to molecular biology and clinical validation, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated towards therapeutic benefit. Cardiovascular disease, vascular biology, heart failure, pharmacology, molecular biology, physiology, regenerative medicine, stem cells, diabetes	Dr David Grieve
MicroRNAs – their role in gene regulation and use as biomarkers Transcriptomics – RNA-Seq, including single cell analysis Microbial DNA sequencing The Wellcome-Wolfson Institute For Experimental Medicine The aim of my research is to apply high throughput molecular genetic approaches, specifically next generation sequencing (NGS), to better understand disease processes such as diabetes in the eye and vascular system. One focus is upon small microRNAs and their role in regulating gene expression, communication between cells and their potential as circulating biomarkers. We are also using single cell RNA sequencing to perform a ‘molecular dissection’ of the retina and study how the many cell types respond to diabetes.	Dr David Simpson
Behavioural science Data science Systems approaches to improving healthcare quality Centre for Public Health Dr Bradley is a clinical lecturer in public health and a consultant in public health medicine in the health and social care service. His research includes qualitative and quantitative studies about equitable access to healthcare services, genomic studies of common and rare diseases, secondary prevention for cardiovascular disease and obesity, and emergency risk communication. Dr Bradley’s current focus is using behavioural science, data science and systems approaches to improving healthcare quality.	Dr Declan Bradley
Cardiovascular medicine Ophthalmology or regenerative medicine. The Wellcome-Wolfson Institute For Experimental Medicine Dr McDonald’s research focuses on developing strategies to preserve normal vasculature and prevent vascular diseases caused by diabetes and aging, with a particular interest in oxidative stress and its impact on vascular growth/function/recovery and tissue repair. More specifically, her group focuses on: Vascular Biology and Cell-Cell Communication: Endothelial / Mural (Pericyte and Smooth Muscle)/ Microglial Cell cross talk; Signalling Pathways: Nitric oxide Synthases (NOS); NADPH oxidase; Reactive Oxygen and Nitrogen Species (ROS/RNS); Notch/Delta (Dll), Hypoxia; Hyperoxia and Inflammation	Dr Denise McDonald
Signal transduction and molecular cell biology Drug discovery targeting Gremlin1 Human iPSC-derived 3D kidney organoids Gremlin1 signalling in human disease The Wellcome-Wolfson Institute For Experimental Medicine Dr Brazil works in a molecular cell biology focused on the role of proteins such as Gremlin1, a secreted antagonist of BMP signaling, in kidney fibrosis and damage. He has been instrumental in the development of multiple unique in vitro and in vivo models to interrogate the biology of Grem1 in kidney disease, including most recently, 3D human iPS cell-derived kidney organoids. His recent data has extended to characterizing the role of Grem1 in colon cancer, and developing novel drug-discovery strategies to inhibit the action of Grem1 in human disease. Gremlin1, BMPs, diabetic nephropathy, kidney, colorectal cancer, organoid, drug discovery	Dr Derek Brazil
Administrative data related to ageing, pensions, poverty at older ages Research on looked after children or children known to social services. Centre for Public Health Using administrative data to explore social factors related to health and well-being, including a study of social inequalities. More recent focus has on mental health, suicide and self-harm, the health of migrants, factors affecting screening uptake, the effects of mixed marriages, the mortality risk of caring or volunteering, patterns of alcohol consumption at older ages, admissions to and care in care homes, the effect of long working-hours, social determinants in the age of retirement and financial wellbeing at older ages.	Dr Dermot O'Reilly
Role of the STING pathway across cancers The Patrick G Johnston Centre for Cancer Research My work focuses on the role of the STING pathway in response to anti-cancer treatment.	Dr Eileen Parkes
Integrate molecular and epidemiological data The Patrick G Johnston Centre for Cancer Research Dr Emma Allott is a molecular cancer epidemiologist whose research integrates epidemiologic methods and design with molecular tumour profiling to identify mechanisms linking dietary and lifestyle factors with cancer risk and progression. She directs -omics and immunohistochemistry analyses of archival tissue specimens to generate molecular epidemiology resources, and leads a research program focused on the role of statin use, high serum cholesterol and dysregulated tumour lipid metabolism in prostate cancer progression.	Dr Emma Allott
Receptor signalling Membrane trafficking Inter-organelle interactions The Patrick G Johnston Centre for Cancer Research Dr Evergren's current research focuses on understanding the molecular mechanisms required for membrane trafficking and receptor-mediated signalling during normal physiology and its contribution to cancer. These are fundamental cellular pathways that regulate processes such as proliferation, migration and tissue remodelling. It is critical to the better understand how receptors are trafficked subcellularly as this determines whether cell signalling is terminated or sustained. A better understanding of these molecular mechanisms is vital to further our understanding of disease mechanisms where these pathways are deregulated.	Dr Emma Evergren Mills
Delirium, in particular postoperative delirium Early diagnosis of dementia Perioperative brain health Centre for Public Health My research focuses on perioperative brain health. For example, studying what postoperative delirium symptoms tell us about underlying brain vulnerability and what we should counsel and offer patients when they do develop acute confusion after surgery.	Dr Emma Louise Cunningham
Epithelial biology Immunology Microbiology The Wellcome-Wolfson Institute For Experimental Medicine Dr Campbell’s research programme focuses on host-microbiota interactions in the gut. Dysbiosis (altered microbiota composition/diversity) is a feature of numerous inflammatory and autoimmune conditions implicated in Inflammatory Bowel Disease(s), Diabetes, Obesity and Cancer. Epithelial cells act as a dynamic interface between the microbiome and the underlying immune system. Our group is interested in strategically targeting mucosal epithelial function with a view to correcting dysbiosis and mitigate chronic inflammation.	Dr Eric Campbell
Population-based cancer registry data, and imputation methods for missing data Waiting-time and ‘routes-to-diagnosis’ cancer statistics Emulating cancer treatment trials in audit data Causal inference mediation analysis Cancer patient survival variation and prognostic modelling Centre for Public Health Dr Bannon’s research expertise lies in applying novel statistical methods to understand variation in cancer patient survival. Modifiable causes include delays in diagnosis and treatment, and suboptimal treatment. These realities vary across sub-groups of the population defined—for instances—by age and the socio-economic deprivation. Population-based cancer registry data can measure population survival variation and explore its causes. Dr Bannon’s research aims to provide better statistical evidence to support change in cancer care services that improves, and reduces inequities in, cancer patient outcomes. Cancer Patient Survival; Population-based cancer statistics; Statistical Methods	Dr Finian Bannon
Infection Pain and inflammation in the oral cavity and upper respiratory tract The Wellcome-Wolfson Institute For Experimental Medicine The Lundy group is particularly interested in the early phases of repair following tissue injury or infection. We have studied the transient receptor expression (TRP) channels as molecular sentinels of tissue injury and described a neurogenic component to inflammation in the oral cavity. Funding for current/recently completed research has been granted from a wide range of funding bodies including EU INTERREG, MRC, NC3Rs, Animal Free Research, Pain Relief Foundation, Arthritis Research UK, British Endodontic Society and British Society of Periodontology.	Dr Fionnuala Lundy
Diabetic complications Biomarker discovery Stratified Medicine Centre for Public Health Research interests focus on biomarker discovery including identification of (epi)genetic and risk factors associated with diabetic kidney disease, diabetes, dementia and other chronic diseases with a microvascular component. Other research interests include nutrition related risk associated with dementia and the underlying genetics of Age-related Macular Degeneration (AMD). Ongoing investigations include genetic and epigenetic associations with socioeconomic status, serum levels of vitamin E, retinal microvascular parameters and their influence on cognition and renal outcomes.	Dr Gareth McKay
Improving oral health for care home residents Exploring links between oral health and nutritional well being Improving care for head and neck oncology patients Centre for Public Health Professor McKenna’s research is centred on optimising treatment options for older patients which positively impact their dental and overall health. His current position combines research, clinical teaching and specialist patient care. He is the immediate past President of the Irish Division of the International Association for Dental Research (IADR) and past President of the European College of Gerodontology (ECG) as well as the Vice President of the Geriatric Oral Research Group (GORG) at IADR.	Professor Gerry McKenna
Messenger (m)RNA localisation and local translation in the context of angiogenesis The Wellcome-Wolfson Institute For Experimental Medicine My research focuses on the spatial regulation of gene expression in the context of endothelial biology. I investigate how RNAs are transported in endothelial cells, how protein synthesis is regulated within subcellular domains and how these mechanisms regulate blood vessel development and function.	Dr Guilherme Costa
Biomedical informatics (translational bioinformatics and exposome informatics) Integration of clinical and molecular data Analysis and representation of exposome data The Wellcome-Wolfson Institute For Experimental Medicine The final aim of our research interest is to foster and advance in what is currently understood as precision medicine applying biomedical informatics. Based in the idea that phenotypes are derived from the interaction of genetic and environmental factors we work in the analysis and integration of exposome (environment), genome & clinical data and information for a better understanding of the mechanisms of disease.	Dr Guillermo Lopez Campos
Data analysis Epidemiology projects related to risk, prevention, early detection and survival of cancers of the digestive tract, particularly oesophageal, pancreatic, liver or colorectal cancer, and associated pre-malignant conditions Centre for Public Health Professor Coleman's research mostly focuses on the epidemiology of gastrointestinal cancers and pre-malignant conditions, with particular strengths in Barrett's oesophagus and oesophageal adenocarcinoma, colorectal polyps and colorectal cancer. She has specialist training in molecular pathology epidemiology and nutritional epidemiology.Her research mostly incorporates data analysis from population-based registers, existing cohort and case-control studies, and systematic reviews of these study designs, as well as applying community-based interventions to address underlying risk factors. Cancer epidemiology	Dr Helen Coleman
Systems medicine Computational biology Bioinformatics Complexity science Functional genomics Systems modelling Health data research Cancer research Precision oncology The Patrick G Johnston Centre for Cancer Research My group’s research connects clinical outcomes with biomedical mechanism, pioneering data-intensive approaches to bridge genotype and phenotype for systems and precision medicine. Core activities apply network biology, statistics and machine learning, including polyomics data integration – in order to illuminate molecular control of cell plasticity in health and disease. Indeed, a substantial portion of gene function remains uncharted, especially in mammalian systems, and we fill this knowledge gap by application of sophisticated computational approaches to carefully selected datasets. cancer, data integration, bioinformatics, transcriptomics, proteomics, genomics, polyomics, EMT, metastasis, drug resistance, network biology, network medicine, systems thinking, machine learning, biomedical science, cell plasticity, precision medicine, modelling, genetics, regulatory network, patient stratification, risk stratification, diagnostic, translational research, therapy, prognostic, predictive, mechanism, deep learning, statistics, mathematics, probability, precision medicine	Dr Ian Overton
Harnessing inflammation for repair and regeneration in dental tissues neuronal-immune cells signalling in inflammatory and neuropathic pain Investigate potential links between oral bacteria, systemic inflammation and cardiovascular disease The Wellcome-Wolfson Institute For Experimental Medicine The goal of my research is to develop minimally invasive, biologically based therapies for inflammatory dental diseases. I have particular interest in investigating the link between pain, inflammation and regeneration as well as the implications of dental disease on general health. Research interest: Stem cells and regenerative therapies Orofacial pain Minimal intervention dentistry Oral infections and systemic health	Dr Ikhlas El Karim
Exploring both phenotypic as well as molecule association between changes in the eye and in the brain The Wellcome-Wolfson Institute For Experimental Medicine Research in the Lengyel group focuses on the ocular manifestations of again and age-related degenerative conditions like macular degeneration and extend to manifestations of diseases of the brain, especially dementia. The laboratory conducts translational research that includes imaging of patients using high-end clinical methodologies and laboratory methods including single-cell sequencing, multi-omic approaches and cell and tissue biology. dementia, retina, calcification, zinc, macular-degeneration, age, molecular biology, cell biology, laser capture, omics, stem cell	Dr Imre Lengyel
Digital molecular pathology approaches to characterize the immune contexture of cancers using high quality biosamples Investigating the role of the oral microbiome in cancer risk and malignant transformation Identifying and validating molecular biomarkers for stratification of patients with cancers The Patrick G Johnston Centre for Cancer Research Dr Jackie James’ research is centred on characterizing the immune contexture of cancers, using innovative approaches in molecular digital pathology. Her work is carried out within a large successful molecular tissue hybridization and digital pathology operation in the QUB Precision Medicine Centre. Dr James uses high quality, pathologically assured tissues to identify and validate novel biomarkers for cancer predication, prognosis and response to therapy.	Dr Jacqueline James
Technology/platform-agnostic prior knowledge transfer Compositional statistics Pre-clinical model selection/chacterisation Prognostic/predictive subtyping Consensus/meta-clustering Landmark analysis Progression routes from pre-malignancy to cancer Mixed signal deconvolution/convolution The Patrick G Johnston Centre for Cancer Research Dr Blayney’s main research focus is the development and application of novel bioinformatics methods that enable the discovery of predictive and prognostic patient subgroups and accelerate product development in inflammatory disease and cancer.	Dr Jaine Blayney
Sociocultural and critical approaches to medical education Health inequalities Identities and culture Health professional education in post-conflict societies Trauma-informed practice Any broad theme of social justice in education Centre for Medical Education Dr Johnston is a critical educationalist and practising GP. Her research uses diverse qualitative methods to explore education as a vehicle for change and social justice within medicine. She has a particular interest in transdisciplinary research. Dr Johnston welcomes PhD applications from a broad range of health professions and social science backgrounds. No qualitative experience is required- just an open mind. Critical pedagogy, sociocultural, discourse, identity, education	Dr Jenny Johnston
To study the role of the histamine four receptor in the regulation of neutrophil phagocytosis To study the role of acidic pH in the regulation of anti-microbial functions of neutrophils The Wellcome-Wolfson Institute For Experimental Medicine My research is focused on understanding the role of two G protein-coupled receptors in the regulation of anti-microbial functions of neutrophils. These receptors are: the histamine four receptor (H4R) and the proton-regulated receptor GPR68. During chronic lung inflammation, histamine level may raise in lung fluids and tissues. In parallel the pH drops due to the high metabolism of bacteria. Histamine and acidic conditions may impair neutrophil anti-microbial functions by controlling the activity of the H4R and GPR68, respectively.	Dr Karim Dib
Mechanisms of radioresistance Drug radiotherapy combinations In vivo models and small animal radiotherapy Nanoparticle theranostics The Patrick G Johnston Centre for Cancer Research Dr Butterworth’s research focusses on improving the biological effectiveness of radiotherapy by understanding the molecular mechanisms of radiobiological responses in tumours and normal tissues. Using advanced preclinical models of radiation response, his group aims to develop biologically targeted strategies for the realisation of precision radiotherapy.	Dr Karl Butterworth
Cellular DNA damage response system and its link with cancer development The Patrick G Johnston Centre for Cancer Research Dr Savage’s research focuses on understanding the cellular DNA damage response/repair systems with a particular emphasis on how defects in these pathways, such as BRCA1 mutations, contribute to cancer development, progression and response to treatment. His work also focus’s on harnessing this knowledge to develop novel therapeutic and chemopreventive strategies for women at high-risks of breast and ovarian cancer due to mutations in DNA repair genes such as BRCA1, BRCA2 and ATM.	Dr Kienan Savage
Behaviour change interventions focusing on diet and/or obesity across a range of population groups Obesity management Preconception health for men and women - improving health status before pregnancy Centre for Public Health As a psychologist, my research focuses on theory-based behavior change interventions to improve diet and nutrition status and to prevent and treat obesity in a variety of population groups. I have a particular interest in the role of novel behavior-change methods such as habit formation and peer support, and I am keen to explore dietary behaviour change across the life-course, including in preconception, pregnancy and aging populations.	Dr Laura McGowan
Development and application of systems thinking and complex systems science lens and methods to public health subjects, including but not limited to population patterns of health-related behaviours, determinants of non-communicable diseases, urban health, and health inequalities. Physical activity and public health, particularly the determinants of population levels of and inequalities in physical activity and the consequent population health impacts. Centre for Public Health Systems thinking and complex systems science applied to public health. Determinants and consequences of population levels of and inequalities in physical activity behaviour. Public Health; Population Health; Systems Thinking; Complex Systems Science; Complexity; Physical Activity.	Dr Leandro Garcia
Cancer epidemiology Autoimmune conditions in particular pernicious anaemia. Centre for Public Health As Acting Deputy Director of the Northern Ireland Cancer Registry, Dr Anderson has an interest in cancer registration working internationally in this area. Her research focuses on infection and immunoepidemiology. Ongoing research includes infectious agents and their association with oesophageal cancer, HPV and oropharyngeal cancer outcomes, cervical cancer screening and trends in cervical pre-malignancy diagnosis. Dr Anderson’s research also focuses on cancer research in low and middle income countries including Angola, Africa and Vietnam.	Dr Lesley Anderson
Design, conduct and evaluation of mixed-methods qualitative research on cancer blindness prevention and pediatric palliative care in LMICs. Centre for Public Health As a Lecturer in Global Health and a medical anthropologist, my research focuses on identifying and overcoming barriers to equitable access and use of healthcare services, particularly in low-resource areas. Ongoing research includes reducing time to breast and cervical cancer diagnosis (Angola, Vietnam), ways to promote screening and follow-up care by people with diabetic retinopathy or glaucoma (Vietnam, China), and working with experts to establish pediatric palliative care where it is not yet in place in Africa.	Dr Lynne Lohfield
Physical activity Sedentary behaviour and exercise in schools, workplaces or with older adults Centre for Public Health Dr Tully’s research focuses on addressing population levels of physical inactivity and sedentary behaviour, which are major causes of death and disease, including cardiovascular disease, cancer and diabetes. This involves developing and testing innovative approaches to engaging people of different ages to change their day-to-day behavior. These approaches range from interventions for patients with specific health needs, targeting places where people spend a lot of time such as in school, or examine the impact of changing the environment. Find out more	Dr Mark Tully
Innate immunity Cell and molecular biology Retinal pathophysiology The Wellcome-Wolfson Institute For Experimental Medicine Dr Chen’s is interested in the immunopathogenesis of retinal degenerative diseases, including age-related retinal degeneration, diabetic retinopathy and uveitis. Her research is focused on 1) how inflammation and inflammatory components contribute to the initiation and development of retinal degenerative diseases, 2) the pathophysiology of Műller glia in retinal diseases, 3) the link between inflammation and metabolism on, and 4) ocular drug delivery	Dr Mei Chen
Investigate key processes involved in the underlying biology driving epigenetic alterations Nucleotide metabolism in cancer development Novel drug targeting of these processes through in vitro cell line-based models and in vivo cancer mouse models. The Patrick G Johnston Centre for Cancer Research The work in our group focuses on the impact of altered nucleotide metabolism and epigenetics in cancer progression and the impact of standard of care therapeutics and novel agents in modulating these processes. Our aim is to contribute to the understanding on the molecular biology level and provide preclinical rational for the translation of our findings to clinical trials to improve patient care.	Dr Melissa LaBonte Wilson
Weight management before, during and after pregnancy Understanding diet and lifestyle behaviours of different groups Developing and evaluating behaviour change interventions Centre for Public Health Dr McKinleys’ research focuses on the ability of dietary interventions to modify nutritional status and risk of chronic disease, particularly diabetes and cardiovascular disease. She also focuses on developing and evaluating complex interventions to support dietary and lifestyle change and weight management throughout the life cycle: examples of work include interventions in the school-setting; before, during and after pregnancy; and for people with type 2 diabetes. This work encompasses the use of e-health and m-health technology to support behaviour change.	Dr Michelle McKinley
Sport and exercise medicine Primary care Musculoskeletal health Cardiovascular prevention Rehabilitation Physical activity promotion App development Centre for Public Health Sport and exercise medicine; road cycling; cardiovascular prevention; physical activity promotion; musculoskeletal health; osteoarthritis treatment; orthopaedics; primary care; rehabilitation; App development.	Dr Neil Heron
Cancer predisposition genetics Molecular pathology Functional genetics The Patrick G Johnston Centre for Cancer Research Dr Orr’s research focuses on understanding the genetic determinants that underpin predisposition and susceptibility to common cancers, with emphasis on breast cancer. His group use epidemiological approaches and functional genetic analysis to identify and characterize regions of the germline genome that influence cancer risk. He is also interested in using genetic approaches for cancer risk stratification, and the development of DNA based approaches for early detection of cancer in high-risk individuals.	Dr Nick Orr
Medical education in the General Practice setting Transformative learning Safe care and quality improvement in healthcare Novel platforms for medical education Centre for Medical Education Dr Hart is open to wide-ranging PhD applications from candidates from an educational or clinical background.	Dr Nigel Hart
Development and implementation of psychological interventions for people with neurodegenerative illness Implementation of quality improvement programs in palliative care Development and implementation of healthcare quality inspection techniques Development and implementation of evidence-based interventions for reduction of loneliness among older people Centre for Public Health Dr McCorry's research is focused on two key areas: Improving the mental health and wellbeing of older people Improving the mental health of specific populations of older people, via the development, adaptation, testing and implementation of feasible and clinically effective interventions and services – in public health and in populations with neurodegenerative illness. Quality Improvement and Implementation Science in Health Services Investigation of quality improvement initiatives and implementation of evidence based practice.	Dr Noleen McCorry
Characterisation of a molecular group in solid cancers that represents an innate immune response to DNA damage through the STING pathway. Development of a gene expression based biomarker panel that can identify pathways related to the hallmarks of cancer and guide patient therapy. The Patrick G Johnston Centre for Cancer Research The Stratified Medicine Group focuses on the following areas: Characterisation of a molecular group in solid cancers that represents an innate immune response to DNA damage through the STING pathway. Development of a gene expression based biomarker panel that can identify pathways related to the hallmarks of cancer and guide patient therapy.	Dr Nuala McCabe
Transcriptional control Signal transduction Chromatin remodeling and epigenetics DNA damage signalling Cell Senescence Molecular cell biology Biochemistry The Patrick G Johnston Centre for Cancer Research Dr Mullan’s group are interested in investigating the molecular driver events responsible for the development and metastases of breast, ovarian and prostate cancers. These molecular events range from oncogene amplifications and aberrant epigenetic regulation to DNA repair deficiencies and dysregulation of epithelial to mesenchymal transition (EMT). We study the control of cell senescence and how cancers can bypass senescence to drive tumorigenesis. We are also interested in developing blood markers of the early detection for high grade serous carcinomas.	Dr Paul Mullan
Translational research The conduct of patient assessment and the relation to clinical measures including risk factors and biomarkers in the various dementia syndromes is the main focus. Centre for Public Health My research focus is cognitive disorders and dementia. This includes the risk factors, prevention, genetic predictors and treatment. Current studies involve dental inflammation and dementia, use of electronic care record to improve dementia care, delirium and dementia and diabetes management and dementia.	Dr Peter Passmore
Cancer molecular biology Digital pathology Computational biology The Patrick G Johnston Centre for Cancer Research Dr Dunne's research programme is focused on investigating mechanisms underlying disease progression in colorectal cancer, with a particular interest in signalling associated with early dissemination of tumours cells and their interaction with the tumour microenvironment. The research programme also includes development of molecular subtypes, using signalling associated with intrinsic (epithelial) and extrinsic (stromal and immune) components of the tumour. His group employs a wide range of laboratory techniques, both “wet-lab” and “dry-lab”, by combining in vivo and in vitro molecular biology, in situ molecular pathology and in silico translational bioinformatics.	Dr Philip Dunne
Inflammasomes Inflammation Innate Immunity PRR signalling pathways The Wellcome-Wolfson Institute For Experimental Medicine My research focus is inflammation and the molecular processes that trigger this response in the innate immune system. I study how protein complexes called inflammasomes cause inflammation, and how they can be targeted therapeutically to prevent damaging inflammation. I have led the biological characterization of a small molecule called MCC950 that inhibits the NLRP3 inflammasome, a driver of many of prevalent diseases such as type 2 diabetes, Alzheimer’s disease, Parkinson’s disease, gout, multiple sclerosis, and atherosclerosis. I am also interested in the regulation and function of inflammasomes specifically in human cell types such as macrophages.	Dr Rebecca Coll
Vascular stem cell biology Diabetic retinopathy Diabetic vascular complications Cellular senescence Angiogenesis The Wellcome-Wolfson Institute For Experimental Medicine The Medina Lab investigates vascular regeneration and therapeutic angiogenesis.Our work aims to develop novel cell therapies for ischaemic disease. Diabetes is a major target disease for our research, because vascular complications are frequent and devastating in diabetic patients. We are interested in understanding the basic pathogenic mechanism for endothelial damage during diabetes, and also in establishing new approaches to repair blood vessels.	Dr Reinhold Medina
Laboratory based investigations of novel drugs and biomarkers Discovery of resistance mechanisms to therapy Innovative biomarker development using clinical samples The Patrick G Johnston Centre for Cancer Research The Upper GI Translational Research group studies biomarkers and drug resistance mechanisms in cancers of the oesophagus, stomach and pancreas. The group incorporates a comprehensive research programme of research laboratory, tissue and plasma biobanking and a clinical trials in order to translate scientific discoveries into clinical practice.	Dr Richard Turkington
MRes project: Development of Novel Cathepsin V inhibitors to Validate role in Breast Cancer MRes project: Testing of Epigenetic Probes in Cancer Immune Cells MRes project: Design, synthesis and SAR exploration of Novel LSD1 inhibitors The Patrick G Johnston Centre for Cancer Research The CCRCB Drug Discovery lab is focused on the development of highly potent, selective and drug-like lead compounds for the treatment of human diseases. Working for PIs in the University we have developed a number of small molecule protease inhibitor tool compounds, that are currently being utilized to validate their target proteins as bone-fide drug targets.	Dr Richard Williams
Clinically-focused research, Relating to improving the diagnosis of serious infection in hospitalised patients, such as diagnostic accuracy studies. The Wellcome-Wolfson Institute For Experimental Medicine My research theme is novel infection diagnostics, predominantly in the intensive care unit setting, to improve outcomes for patients and identify strategies to address antibiotic resistance. In support of this aim, I have a leadership role in several large national multicentre clinical trials. These are funded by NIHR and industry partners and they focus on investigating the effectiveness of new diagnostic and treatment strategies, for patients with serious infections, in the NHS.	Dr Ronan McMullan
Ophthalmic epidemiology Optometry Vision science Psychophysics Ophthalmology Centre for Public Health Dr Hogg’s lab is focused on the following themes: The epidemiology of age-related eye diseases such as Age-related macular degeneration (AMD), Diabetic Retinopathy and Glaucoma. Exploring the utility of new technologies for measuring and monitoring visual function including both handheld devices and virtual reality headsets. Identifying structural, serological and functional biomarkers of Age-related macular degeneration (AMD) and Diabetic Retinopathy using traditional statistics and machine learning. Understanding the differences between normal ocular ageing and the earliest stages of AMD, diabetic retinopathy and glaucoma.	Dr Ruth Hogg
The role of social networks and network interventions for behavior change Developing and investigating the public health impact of population level built and social environment interventions Centre for Public Health Dr Hunter's research interests are in the development and evaluation of complex public health interventions for behaviour change at the community and population level. Her research involves investigating the role of social networks, and the built and social environment for population level behaviour change. Most recently she was awarded a NIHR Career Development Fellowship to investigate the role of social network interventions for behaviour change involving collaborations with the University of Southern California, Harvard University, Yale University and the University of Cambridge.	Dr Ruth Hunter
Laboratory based investigations into molecular mechanisms including altered pro-survival signaling pathways in RASMT and BRAFMT CRC Discovery of novel resistance mechanisms to therapy mechanisms in RASMT and BRAFMT CRC Innovative biomarker development using samples from RASMT and BRAFMT CRC patients The Patrick G Johnston Centre for Cancer Research RAS and BRAF mutated (MT) colorectal cancers (CRC) occur in >60% of CRC patients and are associated with poor outcome. Although the therapeutic armamentarium of CRC has increased over the last 2 decades, there are subgroups of RAS and BRAFMT CRC in urgent need for novel treatments. The research is focused on the identification of novel targets and pathways that are particularly relevant to drug resistance in the context of RAS/BRAFMT at the bench and applying this at the bedside.	Dr Sandra Van Schaeybroeck
Mental health Ageing Co-morbidity/multi-morbidity Social determinants of health/social environment. Subjective well-being Centre for Public Health Dr Cruise’s broad research area is the epidemiology of mental health in an ageing population, with a specific focus on older adults with associated co-morbidities (e.g., disability resulting from chronic illness; cognitive/sensory impairments). She also has a particular interest in the social determinants of health, and in exploring the impact of early life factors on later life health outcomes. The majority of Dr Cruise’s research involves secondary analysis of cohort study data, thereby maximising the utility of existing longitudinal datasets.	Dr Sharon Cruise
Transcription dysfunction in disease Functional genomics and integrative bioinformatics Identification of novel genomically informed treatment strategies The Patrick G Johnston Centre for Cancer Research The Functional Genomics Group focusses on the use of cutting-edge genomics technologies to investigate transcription factor function and de-regulation in cancer with a particular interest in the p53 family. We believe that a better understanding of the genome-wide targets, mechanism of action and consequences of de-regulation of key transcription factors; will allow us to identify cancer specific dependencies, that represent “Achilles heels”, exploitable with novel treatment strategies to improve patient outcomes.	Dr Simon McDade
Innate immunity Repair and regeneration MiRNA function Transcriptomics in the field of acute and chronic lung inflammation and disease The Wellcome-Wolfson Institute For Experimental Medicine Dr Weldon's research programme is centred on host defence mechanisms and their regulation in acute and chronic lung inflammation to better understand the pathogenesis of lung diseases, such as Cystic Fibrosis. Current projects are focussed on (1) developing novel biomarkers of pulmonary infection, inflammation and damage, (2) increasing understanding of innate host defence protein and microRNA function and their roles in disease pathogenesis, (3) investigating novel therapeutic strategies to repair and regenerate the lung in acute and chronic lung disease.	Dr Sinéad Weldon
Proton and ion relative biological effectiveness Genetic determinants of intrinsic radiosensitivity The impacts of intercellular communication on radiation responses Computational modelling of cancer responses The Patrick G Johnston Centre for Cancer Research Dr McMahon’s research focuses on applying mathematical and computational techniques to better understand and optimise responses to radiation therapy for cancer. These techniques are applied in a range of areas including predicting variations in individual radiation sensitivity based on underlying genetic features, and better understanding the effects of different types of radiation such as X-rays, protons, and carbon ions. By linking these models with the clinic, they can bridge the gap between lab and clinic and inform future radiotherapy treatments. Radiotherapy; Cancer; Mathematical Modelling; Individual Sensitivity; Personalised medicine	Dr Stephen McMahon
Improved understanding of tumour initiating events in BRCA mutation carriers Investigation and management of breast cancer risk Development of treatment biomarkers in the pre-surgical setting The Patrick G Johnston Centre for Cancer Research Mr. McIntosh’s research is focused on breast cancer, and he works closely with Dr. Kienan Savage in the DNA Damage Repair Group. improved understanding of the development of breast cancer in high-risk women, enabling improvement of their clinical management. developing biomarkers for better selection of primary systemic treatments for breast cancer and facilitating personalisation of surgical approach. The group’s research programme encompasses laboratory research and translational studies, and extends to clinical trials, enabling translation of scientific findings into clinical practice.	Dr Stuart McIntosh
Biology, physics and clinical PhDs to work with our large team to analyse clinical trial information and samples with a view to identifying novel predictive and prognostic biomarkers for radiotherapy treatment in prostate cancer. The Patrick G Johnston Centre for Cancer Research Clinical translational prostate cancer research and clinical trials. Our group is focused on translating promising preclinical research into early phase patient clinical trials. Similarly, we routinely collect novel patient samples and clinical information for preclinical research	Dr Suneil Jain
Respiratory syncytial virus biology, pathogenesis, and vaccines. Paramyxovirus vaccine vectors, in particular Sendai virus. Culture and exploitation of well-differentiated primary human airway epithelium cell cultures. The Wellcome-Wolfson Institute For Experimental Medicine Dr. Power’s research is focused on studying respiratory syncytial virus (RSV) pathogenesis and how this can be prevented by vaccines or treated with drugs. RSV is the principle cause of severe respiratory diseases, such as bronchiolitis, in young infants worldwide. Despite the enormous disease burden, there are still no vaccines or specific therapies available. His group developed novel models of RSV infection based on well-differentiated primary paediatric airway epithelial cell cultures to study RSV pathobiology using powerful molecular and bio-imaging techniques.	Dr Ultan Power
Cancer clinical trials Basic scientific and translational investigation of mechanisms of treatment resistance The Patrick G Johnston Centre for Cancer Research Development of early to late phase cancer clinical trials with a particular focus on colorectal cancer and melanoma as disease sites of interest. Correlative translational and basic scientific research investigating mechanisms of treatment resistance and response.	Dr Vicky Coyle
Discrete choice models Data analysis Longitudinal data Quantitative Methods Psychometrics Centre for Public Health Dr Vikki O’Neill is a lecturer in medical statistics. She has a particular interest in the development and application of quantitative methods and econometric research issues in health. She has specialist training in discrete choice models, where her recent research has focused on developing these models on African data. Other research interests include; latent variable modelling, intra-household decision making, multi-state models, and psychometrics.	Dr Vikki O'Neill
Encompass training in highly skilled laboratory techniques as well as in transferable skills. The Wellcome-Wolfson Institute For Experimental Medicine The Dombrowski group is interested in the underlying immunological mechanisms that modulate tissue regeneration after sterile or infectious tissue damage. Our goal is to identify novel therapeutic targets for incurable immune-mediated diseases such as Multiple Sclerosis. Current PhD projects investigate the role of inflammasomes in tissue regeneration in the CNS in models of Multiple Sclerosis, inflammasome function in the lung after infectious tissue damage and the effect of e-cigarettes on inflammasome activation	Dr Yvonne Dombrowski
Pharmacology Spatiotemporal aspects of GPCR signalling Pathophysiology The Wellcome-Wolfson Institute For Experimental Medicine G protein-coupled receptors (GPCRs) represent the largest family of proteins targeted by pharmaceutical industry as they regulate many cellular functions. Classically, GPCRs signal at the plasma membrane. Their internalisation leads to signalling arrest. However, recent studies revealed that upon internalisation, some GPCRs signal from intracellular compartments leading to sustained signalling far from plasma membrane. This differential spatiotemporal signalling mediates unique cellular functions exploitable for novel pharmacological treatments. Dr. Plouffe’s research programme aims to tackle important questions underlying this signalling mode.	Dr. Bianca Plouffe
Cellular microbiology of bacterial respiratory pathogens Functional genomics of bacterial virulence factors Subversion of innate immune cells by infection Proteomics approaches to study signaling at the pathogen-host interface Discovery of new antimicrobials The Wellcome-Wolfson Institute For Experimental Medicine The Schroeder Team uses a multidisciplinary approach employing microbiological, cell biological and biochemical methods combined with cutting-edge imaging, transcriptomics and proteomics to elucidate the molecular mechanisms of host subversion by bacterial pathogens, in particular Legionella pneumophila and recently Nontuberculous Mycobacteria. The evolutionary pressure to combat host defences made these bacteria smart cell biologists and understanding their virulence factors often reveals new knowledge how eukaryotic cells function. We aim to translate the knowledge into innovative treatments and diagnostics for infectious diseases. microbiology, cell biology, biochemistry, infection, bacteria, host-pathogen interaction, virulence, innate immunity, antimicrobials, cellular microbiology, immunobiology, respiratory infection, opportunistic infection, healthy aging, immune modulation, macrophages, Legionella, Non-tuberculous Mycobacteria, chemical biology, proteases, glycobiology	Dr. Gunnar N. Schroeder
Molecular mechanisms involved in dysregulation of the ubiquitin proteasome system in multiple myeloma Identify opportunities for therapeutic intervention. The Patrick G Johnston Centre for Cancer Research Dr. Crawford’s principle research interests lie in understanding how alterations in the ubiquitin proteasome system (UPS) contribute to the pathogenesis of Multiple Myeloma and applying this knowledge to identify opportunities for therapeutic intervention.	Dr. Lisa Crawford
Child eye health Low vision, vision impairment and blindness Eye health education Uncorrected refractive error Centre for Public Health Dr Chan's research focuses on investigating the most cost-effective solution to deliver eye health services in low- and middle-income countries (Africa, China and Latin America and the Caribbean). His work looks into the impact of managing child and adult eye health, especially refractive error, on their well-being, which includes: cost-effectiveness of an integrated school eye heath programme, effectiveness of innovative eye health education to improve eye health seeking behaviours, impact of presbyopia correction on adults and disability-related-distresses in visually-impaired children. Child eye health, uncorrected refractive error, global eye health, optometry	Dr. Ving Fai Chan
molecular, cellular, genetic and disease models of inflammation and inflammatory diseases The Wellcome-Wolfson Institute For Experimental Medicine Prof. Moynagh’s research focuses on the sensing mechanisms that are used by the immune system to recognise infectious agents but that can also trigger inflammatory diseases. His research aims to understand the molecular basis to the process of inflammation and he has been to the fore in identifying Pellino E3 ubiquitin ligases and IL-17RD as novel regulators of innate immunity	Prof Paul Moynagh
Harnessing ECFCs to repair choriocapillaris during geographic atrophy The role of the placental growth factor pathway in age-related retinal disease Metabolic plasticity of retinal cells in ischaemia and the potential to regulate physiological angiogenesis Identifying key molecular mechanisms underpinning ECFC dysfunction in diabetic microvascular disease. Development of vascular stem cell therapy for ischaemic retinopathy Combinatorial cell therapy for reversing tissue ischaemia The potential of iPS cell technology to understand mechanisms underpinning patient responsiveness to anti-VEGF agents for diabetic macular oedema The Wellcome-Wolfson Institute For Experimental Medicine Professor Stitt’s research programme is focused on pathogenesis of diabetic retinopathy and age-related retinal disease and the inter-related pathways involved in neuroglial and microvascular dysfunction. With a network of local, national and international collaborative partners, Professor Stitt is interested in vascular homeostasis and also approaches to re-vascularise ischaemic retina. His group have pioneered the use of vascular stem cells as novel therapeutics to treat retinal disease and other microvascular complications of diabetes.	Professor Alan Stitt
Primary and secondary research on visual disorders Centre for Public Health Professor Augusto’s academic career is focused in trying to improve eye care and investigating the efficacy, efficiency and safety of new technologies for eye diseases (e.g., treatments, diagnostic tests, models of eye care). He is the Chief Investigator of several trials, including EAGLE, an international trial for angle-closure glaucoma; GATE, a multicentre diagnostic study evaluating automated imaging technologies in glaucoma; and CHAMP-UK, a multicentre trial evaluating low dose atropine eye drops for children with myopia.	Professor Augusto Azuara-Blanco
Critical care studies that include studies conducted within and after ICU ICU survivorship Trial methodology studies The Wellcome-Wolfson Institute For Experimental Medicine Professor Blackwood’s overarching programme is to improve the conduct of clinical trials and undertake clinical trials in critical care. Her primary interest is the impact and long-term effects of mechanical ventilation and weaning. She leads on funded projects of clinical trials of protocolised weaning; process evaluations of complex critical care interventions; development of core outcome sets for clinical trials; Cochrane systematic reviews and meta-analyses of trials; development of new interventions to minimise delirium and improve rehabilitation for intensive care survivors.	Professor Bronagh Blackwood
Nanomedicine Antibody therapeutics Proteases and pancreatic cancer The Patrick G Johnston Centre for Cancer Research Chris’s research focuses on the development of new antibody and nano-medicine based approaches for the treatment of cancer. His group also works extensively on understanding the complex milieu of the tumour microenvironment, and in particular protease species that are up-regulated in aggressive and metastatic tumours.	Professor Christopher Scott
Health economics Centre for Public Health My research spans a wide variety of areas. These include the examination of disparities in health and healthcare, economic evaluation, policy appraisal, the examination of health utilities and the use of incentives. My work is largely applied in nature. I have supervised to completion 8 PhD and 1 MD in the past 6 years and currently supervise students from the UK and Ireland as well as Vietnam, Saudi Arabia and United Arab Emirates.	Professor Ciaran O'Neill
Tackling protease-mediated inflammation in Acute Respiratory Distress Syndrome Protease-mediated inflammation in chronic lung disease The impact of CFTR modulators on the virome and viral-induced inflammation in early Cystic Fibrosis (CF) lung disease The Wellcome-Wolfson Institute For Experimental Medicine Professor Cliff Taggart has 20 years+ experience in the area of respiratory disease with an interest in dysregulated protease activity in acute and chronic lung disease and its role in altered innate immunity and predisposition to viral and bacterial infection in the airways. Prof Taggart was appointed to the Chair of Respiratory Cell and Molecular Biology at Queen’s in 2007 and his research is funded by MRC, NIHR, EU-H2020, NICHSA, CFF and the Rosetrees Trust. He has previously supervised 22 PhD and 4 MD students to completion. Innate Immunity, Viral and bacterial Infection, Respiratory Disease	Professor Cliff Taggart
Cancer biology Cell death Drug resistance The Patrick G Johnston Centre for Cancer Research The focus of my research is drug resistance. Originally focused on resistance to standard-of-care chemotherapy in colorectal cancer, this work has broadened to include mechanisms of drug resistance in multiple cancers. The mechanism of drug resistance that I have focused on most is cell death, particularly apoptosis. My most significant achievement in this area has been identification of the apoptosis-regulating protein FLIP as a key mediator of drug resistance, a biomarker of poor prognosis and potential therapeutic target for cancer.	Professor Daniel Longley
Developing clinical biomarker strategies in cancer Using comprehensive genomic approaches to detect DNA alterations that can provide clinically meaningful diagnostic, prognostic or predictive information. The Patrick G Johnston Centre for Cancer Research David’s research is centred around molecular biomarker analysis and developing genomic stratification tools for precision medicine with particular focus on developing biomarker strategies for targeted therapies and using circulating biomarkers to better classify and monitor disease. He is involved in several translational research projects identifying diagnostic, predictive and prognostics molecular biomarkers in haematological and solid tumours.	Professor David Gonzalez de Castro
Immunology Neuroscience Stem/Progenitor cell biology Tissue regeneration Neuroinflammation Demyelinating diseases The Wellcome-Wolfson Institute For Experimental Medicine The Fitzgerald lab is a Regenerative NeuroImmunology research group with a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS). Our goal is to identify new strategies to treat MS and other inflammatory and demyelinating disorders. We are particularly interested in myelin regeneration (remyelination) and aim to identify novel therapeutic targets to promote remyelination. To do this, we uncover new knowledge of how the immune system influences CNS stem cells and tissue regeneration.	Professor Denise Fitzgerald
Life-course epidemiology and methods Complex public health interventions Decision sciences. Centre for Public Health Professor Kee focuses on life-course epidemiology and methods, complex public health interventions and decision sciences. In all of these areas there are existing national / international collaborations.	Professor Frank Kee
Simulation based education Medical Education OSCEs Centre for Medical Education Professor Gormley’s main stream of research relates to the simulation based learning in healthcare. Often technology, rather than pedagogy, predominates in healthcare simulation based education. Using dramaturgical and psychological techniques he aims to create a wide range of explicit and implicit cues that allows a more embodied and immersive simulated learning experience. By taking students to the edge of their clinical competency, in a safe and forgiving environment, students have the potential to gain a greater insight into their actions and behaviours expected of them. By extending the context of simulation into areas that doctors often feel unprepared for such as dealing with ethical and moral dilemmas, is a key feature of my research. Furthermore he is developing novel techniques of data capture in such dynamic simulated learning experiences.	Professor Gerry Gormley
Immunology Cell and molecular biology Retinal pathophysiology Pharmacology The Wellcome-Wolfson Institute For Experimental Medicine Professor Xu is interested in the cellular and molecular mechanisms involved in sight-threatening retinal diseases, including age-related retinal degeneration, diabetic retinopathy and uveitis. His research is focused on 1) the initiation and regulation of retinal inflammatory response during ageing and diabetes, 2) autoimmune response in uveitis, 3) the molecular mechanism of inflammation-mediated retinal neuronal degeneration, 4) the link between chronic inflammation and the development of retinal angiogenesis or fibrovascular membrane, and 5) ocular drug delivery.	Professor Heping Xu
Metabolic dysregulation/stress response signaling. The Patrick G Johnston Centre for Cancer Research Prostate cancer is a high-incidence male cancer which progresses to lethal metastatic disease in around 20-30% of diagnosed cases. Our research focus is on identifying biological drivers of disease progression. In so doing we have used genetic, genomic and transcriptomic approaches to show that prostate cancer cells undergo metabolic dysregulation in the early stages of the disease with concomitant stress resistance linked to the unfolded protein response and nucleolar biogenesis. Our entry-points have been the study of transcription factors, the androgen receptor and c-Myc in particular. We are now endeavouring to generate pre-clincial models which better define the reprogramming factors that best reflect the transition for localized to metastatic disease.	Professor Ian Mills
Nutrition Particularly dietary intervention studies Projects involving innovative dietary assessment Behaviour change interventions. Centre for Public Health Professor Woodside’s group, in the Centre for Public Health and Institute for Global Food Security, specialize in the use of biomarkers to assess dietary intake, the conduct of human nutrition intervention studies examining clinically relevant endpoints, and also in interventions to promote long term dietary change.	Professor Jayne Woodside
Bone-seeking radionuclides in prostate cancer New therapeutics in CRPC Advanced radiotherapy in prostate cancer Genomic stratification in prostate cancer The Patrick G Johnston Centre for Cancer Research Prostate cancer clinical trials focusing on: The use of ionizing radiation in advanced disease Molecular radiotherapy, in particular Radium-223 in prostate cancer metastatic to bone. New therapeutics in CRPC	Professor Joe O'Sullivan
Airway Clearance Exercise and rehabilitation Methods for optimizing clinical trials The Wellcome-Wolfson Institute For Experimental Medicine Professor Bradley’s research programme is focused on respiratory health. She is involved in several programmes exploring the effectiveness of therapies linked to optimising airway clearance via pharmacological and non-pharmacological approaches as well as rehabilitation and adherence interventions. These programmes are funded for example by MRC, NIHR and are multi-centre and employ a wide range of trial designs (RCT, observational) and methodologies (both quantitative and qualitative methods).	Professor Judy Bradley
Benign Malignant urolog Ion channels in health and disease The Patrick G Johnston Centre for Cancer Research My research group works on pelvic cancers including bladder, prostate and ovarian cancers in addition to pathophysiology of the urinary bladder. We combine cell physiology and molecular biology approaches to understand how ion channels are involved in the progression of these cancers. We also work with radiation biologists and clinical oncologists to better understand the mechanisms underlying damage to the bladder that occurs as a result of radiation therapy for pelvic cancers.	Professor Karen McCloskey
There are opportunities to investigate molecular mechanisms in myeloid blood cancers including epigenetic alterations, DNA repair deficiency, altered signal pathways to identify therapeutic targets for novel agents or repurposed drugs using drug screens and/or NGS technologies to improve patient outcomes. The Patrick G Johnston Centre for Cancer Research Our understanding of the molecular complexity of the aggressive blood cancers Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndromes (MDS) has increased dramatically in recent years; however, the available therapeutic options are limited due to the disease complexity. The research is focused on identifying less intensive and more effective therapies through in silico and in vitro drug screens to identify novel and repurposed agents and dissecting the effects of defective DNA damage and the specific mutations such as SF3B1 or STAG2.	Professor Ken Mills
Optimization of bone-seeking radionuclides for targeted molecular radiotherapy Defining stem-cell mediated radioresistance in recurrent brain tumours Building a biological-based rationale for the use of particle-based radiotherapies Understanding Radiation-induced bystander and abscopal responses Defining Next generation laser-produced ion-beams for advanced radiotherapy The Patrick G Johnston Centre for Cancer Research My Lab is focused on Radiation Biology Research aiming to optimize the use of radiation(s) as advanced radiotherapy modalities and minimize the risk associated with uncontrolled exposures. I work with a multidisciplinary team of Radiation and Cancer Biologists, Bioinformaticians Radiation Physicists, and Clinical Oncologists. We collaborate, locally, nationally and internationally with some of the top global radiotherapy centres. Our work includes in silico modelling and preclinical studies in vitro right through to translational studies in patients receiving radiotherapy as part of advanced clinical trials.	Professor Kevin M. Prise
Non-adherence in asthma Stratified Medicine / Personalised medicine Health informatics / Health economics The Wellcome-Wolfson Institute For Experimental Medicine Clinical assessment and mechanisms of severe asthma including management of poor adherence to therapy and disease stratification to deliver personalised therapeutics in severe asthma. I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK ) which aims to deliver early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners. We also have programmes in use of routine health informatics and clinical registries and health economics.	Professor Liam Heaney
Neuroinflammation and airways disease Early life influences on adult respiratory health Cohort studies in Early COPD Phase II/III Clinical trials in cough, asthma and COPD The Wellcome-Wolfson Institute For Experimental Medicine His research focuses on clinical and scientific aspects of airways disease. In collaboration with Lundy (QUB) his research group is exploring the potential of human dental pulp stem cells (hDPSCs) and induced pluripotent stem cell (iPSC) derived sensory neuronal models to study neuro-inflammatory mechanisms associated with chronic cough and COPD. He has extensive clinical trial experience working as Principal Investigator on a number of early phase ‘proof of concept' studies of novel cough therapies.	Professor Lorcan McGarvey
Phenotype Genotype Cancer biomarker development from discovery to clinical adoption The Patrick G Johnston Centre for Cancer Research Manuel’s focus is in relation to phenotype and genotype, with specific interest in the pathway of cancer biomarker development from discovery to clinical adoption. Manuel’s integrated model cuts across technologies and cancer types, taking the clinical/diagnostic need as the key research focus.	Professor Manuel Salto Tellez
Myeloproliferative neoplasms Investigation the causes of congenital erythrocytosis The Patrick G Johnston Centre for Cancer Research Professor McMullin’s research focus is on the myeloproliferative neoplasms and investigation the causes of congenital erythrocytosis. She works on epigenetic mechanisms in myeloprolierative neoplasm and collaborates with colleagues investigating the epidemiology on these disorders. She participates in an active clinical trial programme in myeloproliferative neoplasms and acute myeloid leukaemia	Professor Mary Frances McMullin
Development and evaluation of health services and public health interventions Implementation science and improvement science Integrated health and social services Service organization and delivery Centre for Public Health Professor Donnelly’s Health Services Research Group focuses on improving health services and care for people with chronic conditions by conducting investigations of issues and problems such as need and demand for services, service organisation and delivery, health care quality and efficiency and the effectiveness and cost-effectiveness of health service interventions. Our key interdisciplinary research strands focus on the global challenges of addressing chronic health care. The HSRG comprises also an international strand of Global Health and Health Care Research.	Professor Michael Donnelly
Molecular mechanisms of intrinsic multi-drug antibiotic resistance Biogenesis of the Gram-negative bacterial outer membrane, especially lipopolysaccharide and cell wall peptidoglycan Cellular microbiology of opportunistic Gram-negative bacterial pathogens in phagocytic cells. The Wellcome-Wolfson Institute For Experimental Medicine We use interdisciplinary approaches including molecular genetics, biochemistry, cell biology, and structural biology to understand the pathogenesis of opportunistic Gram-negative bacteria at molecular and cellular levels. Burkholderia, Achromobacter, and Enterobacter species are the main model organisms we use in different aspects of our research program. Current interests are: (i) To advance the understanding of the assembly and modifications of lipopolysaccharide (LPS) and glycosylation of envelope proteins; (ii) To elucidate the molecular basis of intrinsic multidrug antibiotic resistance in resilient opportunities Gram-negative pathogens; and (iii) to exploit our finding to develop novel means to combat antibiotic resistant pathogens.	Professor Miguel A. Valvano
Investigate improving the quality and usefulness of trials and reviews Conduct health services research more generally Conduct research relevant to humanitarian emergencies. Centre for Public Health Mike has worked on randomised trials, systematic reviews and studies of research methodology for nearly 30 years. He has a strong interest in increasing research capacity and in improving access to research. He is Research Director of Evidence Aid, encouraging the use of reviews in the humanitarian sector. He established the Study Within A Trial/Review (SWAT/R) initiatives to support studies of research methods. He has supervised dozens of postgraduate students in Queen’s University Belfast and other universities internationally.	Professor Mike Clarke
Strategies to correct and prevent myopia among children in low-resources areas of LMICs Measuring early outcomes in cataract surgery in underserved areas Improved care for complex diseases such as glaucoma and diabetic eye disease in rural Asia Centre for Public Health Prof Congdon’s work has focused on design and evaluation of high-quality, low-cost models of eye care delivery in areas of limited resources, particularly rural Asia, and frequently involves NGOs working together with academic institutions in Asia and the west.	Professor Nathan Congdon
DNA damage repair Transcriptional regulation Mechanisms of sensitivity/resistance to DNA damage based therapeutics The Patrick G Johnston Centre for Cancer Research Professor Harkin’s research is focused on understanding the impact of mutations within the BRCA1 gene in the development and treatment of hereditary breast and ovarian cancer. We are using a number of complementary strategies to investigate the role played by BRCA1 in both DNA damage repair and transcriptional regulation. We were the first lab to identify a novel BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability following DNA damage.	Professor Paul Harkin
Characterisation of a molecular group in solid cancers that represents an innate immune response to DNA damage through the STING pathway Development of a gene expression based biomarker panel that can identify pathways related to the hallmarks of cancer and guide patient therapy The Patrick G Johnston Centre for Cancer Research The Stratified Medicine Group focuses on the following areas: Characterisation of a molecular group in solid cancers that represents an innate immune response to DNA damage through the STING pathway. Development of a gene expression based biomarker panel that can identify pathways related to the hallmarks of cancer and guide patient therapy.	Professor Richard Kennedy
Microvascular biology and disease Pharmacological Gene therapy-based approaches The Wellcome-Wolfson Institute For Experimental Medicine Professor Tim Curtis (PI) is Chair of Vascular Physiology and one of the Deputy Directors for the Centre for Experimental Medicine. He is also Academic Lead for the Advanced Imaging Core Technology Unit within the Faculty of Medicine, Health and Life Sciences. Professor Curtis’ research team is working to identify new therapeutic targets and approaches for the treatment of diabetic retinopathy. Work in his group is underpinned by fundamental studies on the physiology and biology of the microcirculation in eye and other vascular beds.	Professor Tim Curtis
No current opportunities The Patrick G Johnston Centre for Cancer Research Protein degradation, ubiquitin-proteasome system, drug discovery, apoptosis, deubiquitinases, protein therapeutics, protein-drug conjugates, medicinal chemistry	Professor Tim Harrison
Ophthalmic image analysis Diabetic retinopathy screening Epidemiology of eye diseases in different populations around the world Centre for Public Health Professor Peto's research interests covers chronic blinding diseases, ophthalmic image analysis, epidemiology and statistics.	Professor Tunde Peto
Bioinformatics Epigenetics Genomics Cancer Biology Developmental Biology Neurobiology The Wellcome-Wolfson Institute For Experimental Medicine Epigenetic Regulation of Differentiation and Disease We are particularly interested in studying how cell-fates are specified during development and miss-specified in diseases. The research in my lab is aimed at achieving an integrated molecular and systems-level understanding of the mechanisms by which epigenetic machinery and transcription factors contribute to transcriptional reprogramming that defines cell-type identity during development and how this communication is altered in diseases such as cancer. To investigate these questions, we employ a multidisciplinary approach combining cutting-edge epigenetics and genomics together with computational biology tools in sophisticated and defined models of cellular differentiation and carcinogenesis. The key topics of research in my lab are: Transcription Factors and Cell-Fate Specification Epigenomics of Cell-type Identity Signaling to Chromatin Crosstalk Epigenetic Regulation of Neurogenesis Chromatin and Cancer Systems Biology of Gene Regulatory Networks	Dr Vijay Tiwari
Cancer epidemiology Premalignant disease research including impact of receiving a pre-malignant diagnosis Early detection of cancer Cancer education/awareness Global health Data analysis Mixed-methods Centre for Public Health Dr McShane’s research interests include early detection of cancer with a particular focus on haematological malignancies and associated pre-malignant conditions, cancer awareness/education, and the impact of receiving a pre-malignant diagnosis. Dr McShane’s research programme also includes cancer research within low-and middle income (LMIC) countries such as Angola, Mongolia, Uganda, and Vietnam.	Dr Charlene McShane
Severe asthma epidemiology Unwarranted geographic variation Social determinants of disease Centre for Public Health Although his research interests are varied, Dr. Busby is primarily interested in severe asthma outcomes. He is the lead statistician for the UK Severe Asthma Registry and has recently been involved in efforts to combine data from across Europe (DOI:10.1183/13993003.01163-2019) and Worldwide (DOI: 10.1016/j.chest.2019.10.053) to enable real-word research studies in severe asthma at truly international scale. His future research plans include exploring socioeconomic and ethnic inequalities in asthma within the UK.	Dr John Busby
Epigenetic mechanisms in Leukaemia and Lymphoma BTK signalling and epigenetic regulation in autoimmune disorders Epigenetic and transcriptional dynamics in immune cells upon infection The Wellcome-Wolfson Institute For Experimental Medicine Understanding the molecular mechanisms underlying treatment failure in chronic diseases such as leukaemia is an essential biological question with important clinical impact. In the last years, we have performed high throughput characterization of the enhancer landscape in Chronic Lymphocytic Leukaemia upon BTK inhibitory treatment aiming at shedding lights into Ibrutinib-treatment resistance mechanisms beyond the well-described mutations. Next, our lab research mission is to: i) investigate the role of key enhancers and transcription factors as major modulators of the transcriptional landscape in immune cells ii) defining the molecular and epigenomic feature of normal, autoimmune and. malignant B -cell of diverse maturation status in the presence of 1st and 2nd generation targeted therapeutic agents.	Dr Effie Kostareli
Acute respiratory physiotherapy, and airway clearance in acute respiratory failure Rehabilitation in critical illness Recovery, long-term outcomes, and survivorship after critical illness Clinical trial methodology in complex rehabilitation interventions Core outcome sets The Wellcome-Wolfson Institute For Experimental Medicine Acute respiratory and rehabilitation physiotherapy, the recovery, long-term outcome, and survivorship of post critical illness patients, and clinical trial methodology around complex rehabilitation interventions. Current work includes development of a core outcome set for trials of physical rehabilitation in critical illness, and leading a multiprofessional team developing a randomized controlled trial investigating the effectiveness of mucoactive drugs in acute respiratory failure.	Dr Bronwen Connolly
General Practice, learning in healthcare contexts, across the range of health disciplines Centre for Medical Education I am interested in workplace based learning across health professions education, using a range of broadly critical, qualitative approaches. As a General Practitioner (GP), I have particular interest in community healthcare contexts.	Dr Helen Reid
Mental health Psychological trauma Psychosis "At risk mental states" Mental Health and Documentary Film Medical Education Research Resilience training The impact of previous negative life experiences on mental well-being and resilience in medical and other students Rural Mental Health Social and Clinical History of Psychiatry 1. First Episode Psychosis and At Risk Mental States (ARMS): I have a research interest in the impact of childhood trauma on mental health outcomes in young adulthood and have published widely in this area. I am a Principle Investigator on the Northern Ireland First Episode Psychosis Study (NIFEPS). Currently I have a number of studies in the ARMS field, including studies of: inflammatory markers; neuropsychological deficits; RCTs of a new psychotropic; VR technology; EEG technology; epidemiology of the ARMS in educational and population settings. 2. Exploring the Impact of the "Troubles" on mental health: I have a particular clinical and research interest in the impact of violence in the local context of Northern Ireland on mental health outcomes, including studies of: complex grief; RCT of TF-CBT for children.	Dr Ciaran Mulholland
Critical qualitative methods, in particular Institutional Ethnography in Health Professions Education Centre for Medical Education My academic interests include Institutional Ethnography and its use in Health Professions Education and Experience-based learning.	Dr Grainne Kearney
Conversation analysis based studies on healthcare or education Virtual reality in education Retinal vein occlusion Centre for Medical Education Using conversation analysis to explore interactions in healthcare and educational settings. Evaluating the use of technology, including virtual reality, in healthcare education Clinical research on retinal vein occlusion Interaction. Technology. Retinal vein occlusion.	Dr Michael Williams
Virology RNA biology Biochemistry Centre for Medical Education My lab's primary research focus is on the post-transcriptional regulation of influenza A RNAs, including both mRNA and vRNA. For the most part, up to this point we have focused on the regulation by RNA modifications, but we have recently begun to explore the protein interactome of IAV RNA and determining how it differs, and why, from the cellular mRNA protein interactome. RNA influenza epitranscriptomics translation modifications virus	Dr David Courtney
Immunology Immune cell biology Centre for Medical Education I am interested in immune cell interaction and antigen recognition and endocytosis - cellular processes essential for an effective immune response against infectious agents. Infectious diseases cause over 6 million deaths a year worldwide with significant number of newly emerging or highly mutating pathogens. Using techniques from the fields of immunology, cell biology and genetics, I'm studying the molecular mechanisms regulating cell-cell communication and antigen uptake. antibody response, B cells, dendritic cells, endocytosis, antigen presentation, CRISPR/Cas9	Dr Dessi Malinova
Centre for Public Health My main areas of interest include primary research on the diagnosis and treatment of medical retina disorders, visual function, low vision rehabilitation, and particularly systematic reviews of interventions and diagnostic test accuracy studies in eyes and vision as well as in other medical specialties. vision, retinal disorders, systemateic reviews	Dr Gianni Virgili
Critical Care Sepsis Perioperative medicine Anaesthesia The Wellcome-Wolfson Institute For Experimental Medicine My research is focused on improving patient outcomes in critical care and perioperative medicine. My interests include sepsis, fluid therapy and deresuscitation, prevention of post-operative pulmonary complications, acute kidney injury and other aspects of critical care, anaesthesia, and perioperative medicine. critical care, sepsis, ARDS, acute kidney injury, perioperative medicine, post-operative pulmonary complications, anaesthesia	Dr Jon Silversides
Immunology Host pathogen interactions Fungal infections The Wellcome-Wolfson Institute For Experimental Medicine The Orr group focuses on understanding the immune response to fungal pathogens in order to identify potential immunotherapy targets or stratification factors to stratify patient groups at risk of fungal infections in order to target anti-fungal prophylaxis to patients at highest risk of developing serious fungal infections. We have recently generated novel models to fully dissect the role of C-type lectin-like receptors in anti-fungal immunity and we have identified a system to stratify stem cell transplant patients into groups at 'high risk' or 'low risk' of developing invasive aspergillosis. Host pathogen interactions, fungal infections, immunology	Dr Selinda Orr
Paediatric emergency medicine Paediatric infection Molecular diagnostics Biomarker discovery Clinical decision tool derivation and validation The Wellcome-Wolfson Institute For Experimental Medicine I am a Paediatric Emergency Medicine Consultant and Clinical Lecturer in Paediatrics. My research interests include paediatric emergency research, infectious diseases, molecular diagnostics, proteomics and biomarkers. pediatrics, paediatrics, infection, biomarkers, proteomics	Dr Thomas Waterfield
Basic science or clinical background. Major interest is Acute Respiratory Distress Syndrome (ARDS) The Wellcome-Wolfson Institute For Experimental Medicine My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in human models of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. I am currently investigating the role of MSCs, statins and ECCO2R in ARDS. My other current research interests are patient stratification in ARDS, sepsis diagnostics and delirium. Previous research experience is desirable although not essential. Acute Respiratory Distrees Syndrome (ARDS); intenstive care; clinical trials;	Dr Danny McAuley
Early Health Technology Assessment Measurement and Valuation of Health Related Quality of Life Value of Information and analysis of uncertainty Design of innovative market access and reimbursement models for health technologies Centre for Public Health My research has 3 main themes:1) The design of efficient research development in the life sciences to promote the development of high value technologies reaching market at financially sustainable prices offering a commercially attractive return on investment.2) Modelling the interaction between health and health care policies and other socio-economic objectives to improve the evidence base for crisis management strategies such as the COVID pandemic.3) Design of methods and processes for the managed adoption of high risk high value health technologies which are aligned with financial sustainability for comprehensive population health care systems Cost effectiveness, Value of Information, Health Technology Assessment, Measurement and Valuation of Health, One Society, Innovation	Professor Christopher McCabe
Cell and Molecular Biology Genetics Cancer Medicine Biochemistry Experimental Medicine RNA Biology The Patrick G Johnston Centre for Cancer Research Recent advances demonstrated the key roles that the dysregulated mRNA translation and degradation machinery play in various diseases, including cancers. This is further evidenced by development of numerous drugs that target these mechanisms and are in various stages of clinical trials or in clinical use. We study the cellular mechanisms that control mRNA translation and degradation and their roles in patho-phyisiologal contexts such as anti-viral immune response and cancer cells’ response to treatments. mRNA translation, mRNA decay, Gene expression, Cancer Biology, micoRNA, RNA Biology	Dr Seyed Mehdi Jafarnejad
Novel tissue hybridisation technologies and image analysis to support epidemiological research The Patrick G Johnston Centre for Cancer Research Dr Craig is a Lecturer in Precision Medicine at the Patrick G. Johnson Centre for Cancer Research, Queen’s University Belfast. She has expertise in applying and validating translational cancer research methodologies using molecular pathology techniques (immunohistochemistry, in situ hybridisation, multiplex immunofluorescence, digital image analysis) and statistics with a specialist interest in orodigestive cancers (Head and Neck, Oesophageal, Colorectal). Her research focuses on predictive biomarker studies and understanding confounding variables that influence the prediction of poor prognosis subgroups in cancer research including reproducible study design, choice of molecular test, and assessment criteria. Molecular pathology, image analysis, interdisciplinary science	Dr Stephanie Craig
Cancer biology Cancer immunology The Patrick G Johnston Centre for Cancer Research The lab's research interests focus on understanding how proteases and anti-proteases may regulate tumour development, particularly immune cell (T-cells and macrophages) and endothelial cell function in lung cancers. Specifically, the lab aims to assess how proteases and anti-proteases can alter cell phenotypes and behaviours, and to unravel the multifaceted immune mechanisms that allows these pulmonary enzymes to manipulate the tumour microenvironment leading to tumour progression, metastasis and poor response to anti-cancer therapies tumour microenvironment, enzymes, lung, endothelial cells, macrophages	Dr Donna Small

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